CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Instituto de Biociências (IBB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Ciências Biológicas Modalidade Médica from Universidade Estadual Paulista Júlio de Mesquita Filho (1999), master's at Pharmacology from Universidade Estadual Paulista Júlio de Mesquita Filho (2002) and doctorate at General Biology from Universidade Estadual de Campinas (2006). Has experience in Morphology, acting on the following subjects: rat, reproduction, fertility, fertilidade and rato. (Source: Lattes Curriculum)
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N-nitrosamines are agents with mutagenic/carcinogenic potential which can be present in food, cigarettes, cosmetics, and water. Recently, high levels of this compound have been detected in widely used drugs, which have attracted the attention of Anvisa and regulatory agencies around the world. These compounds are metabolically activated by the cytochrome P450 system, leading to the genera…
Exposure to Endocrine Disruptors (EDs) during critical windows of development can cause epigenetic alterations, which can appear immediately or long after exposure, even in subsequent generations. Benzo(a)pyrene (BaP) is a persistent organic pollutant, widely distributed in the environment. Studies have shown that BaP accumulates in vital and reproductive organs, including the testis; and…
Prostaglandins (PGE2) are essential in the process of hypothalamic sexual differentiation, promoting the masculinization of hypothalamus in males. The non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (third class of drugs most used by pregnant) act through non-selective inhibition of COX-1 and 2, with the reduction of PGE2. Thus, when used during pregnancy, these substanc…
Cyclophosphamide (CFA) is extensively used as chemotherapeutic agent in clinical practice for the treatment of cancers. However, this compound causes several adverse effects including reproductive toxicity. As alternative to minimize these adverse effects, the CFA is normally used in combination with antioxidants. Acrocomia aculeata is a common species of palm savanna, known traditionally…
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly used class of medication for the treatment of pain, fever and inflammation, being regularly administered even to pregnant and lactating women. These drugs have an inhibitory effect on the Cyclooxygenase enzyme (COX-1 and COX-2), leading to a reduction in PGE2. Additionally, NSAIDs can act as endocrine disruptors. Studies …
Exposure to environmental contaminants can occur at any time of life, including the so-called critical windows of development. Individuals directly exposed (F0) can show adverse effects in adulthood, as can their indirectly exposed offspring (F2), configuring a multigenerational inheritance. Nitrosamines, a class of substances found in food, widely used medicines and drinking water source…
The multigenerational assessment in this study covers the effects of direct exposure on the parental generation (F0) and the possible consequences of this exposure on future generations (F2), even in the absence of direct exposure to the tested substance. N-nitrosamines are substances considered environmental contaminants that appear as unintentional by-products in industrial production. …
(Only some records are available in English at this moment)
N-nitrosamines are compounds belonging to the class of environmental contaminants and can be found in various products, including food and drinking water sources. Recently, the presence of these substances at high levels has been observed in widely used medicines, which has aroused the attention of regulatory agencies around the world. To date, they are known for their ability to cause mu…
N-nitrosamines are compounds that can be found in drinking water, pesticides, pharmaceutical products, food, and tobacco smoke, which has attracted the attention of the "Agência Nacional de Vigilância Sanitária - Brasil" and international regulatory agencies. The carcinogenicity of N-nitrosamines has been well established after recurrent exposure, but few studies have examined their adver…
N-nitrosamines are agents with mutagenic/carcinogenic potential which can be present in food, cigarettes, cosmetics, and water. Recently, high levels of this compound have been detected in widely used drugs, which have attracted the attention of Anvisa and regulatory agencies around the world. These compounds are metabolically activated by the cytochrome P450 system, leading to the genera…
(Only some records are available in English at this moment)
Endocannabinoids and the innate immune system are two early signaling systems that influence brain development. During a unique critical period in the neonatal amygdala of the rat, innate immune cells of the brain, microglia, actively engulf and kill newborn cells that would have gone on to become astrocytes. This mechanism determines the future density of astrocytes in the amygdala. The …
Microglia is emerging as important regulators of brain development. This cell responds and produces prostaglandin E2 (PGE2), creating a feedback loop. PGE2 is related to inflammation, and early-onset neural inflammation is a leading environmental risk for some disorders. Microglia has a "semi-activation" peak during the second post-natal week in healthy cerebellum. Cerebellar development …
| 1 / 1 | Ongoing grants |
| 3 / 3 | Completed research grants |
| 9 / 9 | Ongoing scholarships in Brazil |
| 20 / 17 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 35 / 32 | All research grants and scholarships |
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