CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Faculdade de Medicina (FMB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Medicine (1984) from Botucatu Medical School, Sao Paulo State University (Unesp). Medical residency in cardiology at the same institution (1985-1988). Masters and PhD degrees from Unesp in 1994 and 2000, respectively. Two years postdoctoral fellowship (2002-2004) in experimental heart failure at Beth Israel Deaconess Medical Center, Harvard University, Boston. Associate professor of cardiology at Botucatu Medical School, Unesp (2011-2019) and full professor since 2019. Research in cardiac remodeling, heart failure, and diabetic cardiomyopathy. (Source: Lattes Curriculum)
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Heart failure (HF) is clinically characterized by a reduced capacity for physical exercise and daily activities. HF is caused by diseases such as systemic arterial hypertension, myocardial infarction, valve disease, and cardiomyopathy. Chronic hemodynamic overload produced by these diseases induces genetic, molecular, cellular and interstitial changes that manifest clinically as alteratio…
Despite advance on cardiac remodeling prevention and treatment, mortality after myocardial infarction (MI) is still elevated. The sodium-glucose co-transporter 2 (SGLT2) inhibitors reduce renal glucose reabsorption improving diabetes control. In the EMPA-REG OUTCOME Study, empaglifozin addition to the standard therapy of patients with type 2 diabetes and high risk for cardiovascular disea…
Systemic arterial hypertension is one of the main cause of heart failure. Amongst changes induced by chronic pressure overload, are abnormalities of collagen tissue and oxidative stress, which can influence myocyte growth and contraction, and interstitial fibrosis. Increase in reactive oxygen species (ROS) activates signaling intracellular pathways as nuclear factor-kappaB (NF-kB) and mit…
(Only some records are available in English at this moment)
Cardiovascular diseases (CVD), the complications of which can cause heart failure (HF), are currently the world's leading cause of disability and mortality, accounting for one-third of global deaths. In Brazil, it is the main cause of hospitalization in patients over 60 years of age. Oxidative stress, which makes up one of the mechanisms related to cardiac remodeling, is involved in the a…
Heart Failure (HF) is clinically characterized by reduced capacity for physical exercise and daily activities. HF is caused by diseases such as arterial hypertension, myocardial infarction, valvulopathies, and cardiomyopathies. Chronic hemodynamic overloads produced by these diseases induce genetic, molecular, cellular and interstitial changes that manifest clinically as alterations in th…
Diabetes mellitus (DM) is a metabolic disorder of multiple etiology characterized by chronic hyperglycemia, which causes disturbances in the metabolism of carbohydrates, fats and proteins, resulting from defects in secretion and/or insulin action. Besides being responsible for damage in multiple organs (nerves, kidneys and eyes), DM is one of the main risk factors for the development of c…
(Only some records are available in English at this moment)
Myocardial infarction (MI) is among the main cardiovascular diseases. After MI, part of the myocardial tissue is not efficient for regeneration into new functional cardiac tissue. Instead, a scar is formed in the infarcted area. The extension of the formed scar determines the tendency to adverse cardiac remodeling. Given the limited capacity for self-renewal, cell-based strategies to rege…
| 10 / 5 | Completed research grants |
| 9 / 5 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 20 / 11 | All research grants and scholarships |
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