CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Faculdade de Medicina (FMB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Medicine (1984) from Botucatu Medical School, Sao Paulo State University (Unesp). Medical residency in cardiology at the same institution (1985-1988). Masters and PhD degrees from Unesp in 1994 and 2000, respectively. Two years postdoctoral fellowship (2002-2004) in experimental heart failure at Beth Israel Deaconess Medical Center, Harvard University, Boston. Associate professor of cardiology at Botucatu Medical School, Unesp (2011-2019) and full professor since 2019. Research in cardiac remodeling, heart failure, and diabetic cardiomyopathy. (Source: Lattes Curriculum)
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Background: Clinical trials have shown that sodium glucose co-transporter 2 (SGLT2) inhibitors improve clinical outcomes in diabetes mellitus (DM) patients. As most studies were performed in Type 2 DM, the cardiovascular effects of SGLT2 inhibition still require clarification in Type 1 DM. We analyzed the effects of SGLT2 inhibitor dapagliflozin on cardiac remodeling in rats with streptoz…
Heart failure (HF) is clinically characterized by a reduced capacity for physical exercise and daily activities. HF is caused by diseases such as systemic arterial hypertension, myocardial infarction, valve disease, and cardiomyopathy. Chronic hemodynamic overload produced by these diseases induces genetic, molecular, cellular and interstitial changes that manifest clinically as alteratio…
Aim: To evaluate the influence of physical training on myocardial function, oxidative stress, energy metabolism, and MAPKs and NF-kB signaling pathways in spontaneously hypertensive rats (SHR), at advanced stage of arterial hypertension, which precedes heart failure development. Methods: We studied four experimental groups: normotensive Wistar rats (W, n=27), trained W (W-EX, n=31), SHR (…
(Only some records are available in English at this moment)
Cardiovascular diseases (CVD), the complications of which can cause heart failure (HF), are currently the world's leading cause of disability and mortality, accounting for one-third of global deaths. In Brazil, it is the main cause of hospitalization in patients over 60 years of age. Oxidative stress, which makes up one of the mechanisms related to cardiac remodeling, is involved in the a…
Heart Failure (HF) is clinically characterized by reduced capacity for physical exercise and daily activities. HF is caused by diseases such as arterial hypertension, myocardial infarction, valvulopathies, and cardiomyopathies. Chronic hemodynamic overloads produced by these diseases induce genetic, molecular, cellular and interstitial changes that manifest clinically as alterations in th…
Diabetes mellitus (DM) is a metabolic disorder of multiple etiology characterized by chronic hyperglycemia, which causes disturbances in the metabolism of carbohydrates, fats and proteins, resulting from defects in secretion and/or insulin action. Besides being responsible for damage in multiple organs (nerves, kidneys and eyes), DM is one of the main risk factors for the development of c…
(Only some records are available in English at this moment)
Myocardial infarction (MI) is among the main cardiovascular diseases. After MI, part of the myocardial tissue is not efficient for regeneration into new functional cardiac tissue. Instead, a scar is formed in the infarcted area. The extension of the formed scar determines the tendency to adverse cardiac remodeling. Given the limited capacity for self-renewal, cell-based strategies to rege…