Newton Sabino Canteras
CV Lattes
ResearcherID
Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
bachelor's at Medicina from Universidade de São Paulo (1980), master's at Physiology from Universidade de São Paulo (1986) and doctorate at Physiology from Universidade de São Paulo (1988). He is currently full professor at Universidade de São Paulo. Has experience in Physiology, focusing on Physiology of Organs ans Systems, acting on the following subjects: comportamento de defesa, hypothalamus, defensive behavior, hipotalamo and comportamento predatorio. (Source: Lattes Curriculum)
- Neuroepigenetic mechanisms underlying intergenerational inheritance of negative emotional states, AP.R
Abstract
Olfactory fear conditioning is a powerful and innovative framework to model intergenerational stress because it allows us to "tag" a stressor in one generation (odor + US) and then follow the tag (odor) in the future offspring at the level of structure (visualize olfactory neurons), function (flow of olfactory information from the periphery into the central nervous system), and genetics...
- Neural bases of fear and aggression, AP.TEM
Abstract
In this Project we propose a broad series of studies to investigate innate and learned fear responses to predatory threats and to evaluate candidate genes related to aggressive behavior. In the first series of studies, we shall first investigate the neural and molecular mechanisms underlying fear memory to predatory threats, examining: a) the role of cortical circuits and dorsolateral ...
- Visit of Dr. D. Caroline Blanchard to the Department of Anatomy February/May 2016, AV.EXT
Abstract
Dr. Caroline Blanchard's visit to our lab will be very helpful to develop ongoing projects in our lab and new proposals to understand the neural basis of defensive aggression. Among the ongoing projects in our laboratory, Dr. Caroline Blanchard will be working in two specific projects, which are part of our FAPESP research grant Neural Basis of Fear and Aggression (Project # 2014/05432-...
- Neural bases of anxiety and social behaviours, AP.R
Abstract
The overall aim is to generate breakthrough advances in the neuroscience of anxiety and social behayiours, and the funding to enable them, by bringing together two neuroscientists (Canteras: São Paulo; Lever: Durham) with highly complementary techniques a (AU)
- Functional ethological investigations into the role of discrete regions of the lateral hypothalamic area implicated by their neuronal connections in the control of defensive behaviors, AP.R
Abstract
The hypothalamus has a central role in the control of fundamental goal-oriented behaviors, but a clear understanding of its structure-function relations remains incomplete. The gaps in our knowledge are particularly evident for the poorly studied lateral hypothalamic area (LHA). However, a series of recent tract-tracing studies have made substantial inroads in to this relatively unstudi...
(Only some records are available in English at this moment)
- Investigation of the neuronal activity in the different functional columns of periaqueductal gray matter in response to a predatory threat and a predatory context, BP.DR
Abstract
Periaqueductal gray matter (PAG) is involved in behavioral responses related to innate and learned fear. These involvements were verified by several methods, among them, indirect markers for neural activity, lesions, inactivations through specific receptor antagonists, activations of different modalities, and through the recording of neuronal activity by chronic implantation for extrace...
- Functional analysis of the neural circutis involved in aggression and social defeat in rodents, BP.PD
Abstract
In rodents, subcortical nuclei have been showed as important areas in reproductive and social behaviors. Our group has focused on mapping brain areas involved in aggressive and defensive behaviors in animals exposed to the resident-intruder paradigm. Circuits encompassing amygdalar, hypothalamic and brain stem sites have been outlined as involved in the mediation of aggressive and defe...
- Functional-anatomical analysis of the neuronal populations in the lateral region of the periaqueductal gray matter involved in predatory hunting and social defense behaviors, BP.PD
Abstract
Several studies have suggested an involvement of the Periaqueductal gray matter (PAG) in different behaviors that may share a component at motivational level. Previous studies from our lab suggest the existence of similar activation patterns of the lateral PAG (lPAG) in response to innate behaviors underlain by opposite motivational drivers, namely, insect predation and intraspecific de...
(Only some records are available in English at this moment)
- Study on the role of the endopirifiorme nucleus and the anterior part of the basolateral nucleus of the amygdala in the predatory, contextual and exploratory fear behavior in a new environment, BP.MS
Abstract
The basolateral nucleus of the amygdala is usually study as the combination of both the lateral nucleus (LA) and basolateral (BLA). The role of BLA and LA in the expression and acquisition of conditioned fear to a painful stimulus has been extensively studied. Experiments conducted in our laboratory confirm that animals with bilateral lesions in the LA show a decrease of innate fear res...
- The role the hypothalamic defensive circuit and its main ascending targets on residual fear responses of animals bearing PAGDL lesions during predator exposure, BP.MS
Abstract
The periaqueductal gray, in particular its dorsolateral part (PAGdl) is known to be critically involved in the organization of innate and contextual fear responses to predatory threats. However, recent findings from our group has shown that PAGdl-lesioned animals exposed to a live predator showed clear fear responses, avoiding the predator and presenting a pattern of cautious exploratio...
- Study of the cortical circuitry involved in contextual fear processing to predatory threat, BP.DD
Abstract
Previous studies from our laboratory showed that memory to predatory threats depends on a hypothalamic-thalamic path involving the dorsal premammillary nucleus and the ventral part of the anteromedial thalamic nucleus (AMv). Thus, it has been shown that cytotoxic lesions of the AMv interfere with the contextual, but not innate, responses to predatory threats. Connective data from our la...
(Only some records are available in English at this moment)
- In vivo study of GABAergic and glutamatergic neuronal populations of the periaqueductal gray matter in response to different kinds of threat, BE.EP.PD
Abstract
Recent technological advances open up causal investigation and specificity for the fast timescales of natural nervous system communication enabling an unprecedented level of hypothesis-testing precision. To understand how neural circuit activity controls behavior, experimental interventions should be performed with genetic, anatomical and temporal precision. Genetically encoded Ca2+ ind...
- Neuronal circuits mediating the behavioral switch between active avoidance and freezing, BE.EP.DR
Abstract
It is well known that the spatial location of an individual towards a potential threat determines the nature of the fear response. Depending on the proximity of the threat, an individual may display a freezing, avoidance or a fight response. One form of avoidance that has been recently investigated is the signaled active avoidance (AA) The neural circuits implicated are now being well i...
- Role of the dorsal premammillary nucleus and its main targets in the expression of innate defensive responses and the acquisition of contextual fear memory during social defeat, BE.EP.DR
Abstract
The dorsal premammillary nucleus (PMd) represents one of the most mobilized sites during social agonistic encounters and provides strong projections to the dorsal part of the periaqueductal gray (dPAG) and the ventral part of the anteromedial thalamic nucleus (AMv). In the present study, we plan to study the role of the PMd and its main targets (i.e., dPAG and AMv) in the innate and con...
- Neural control of metabolism during chronic social defeat, BE.EP.PD
Abstract
In mice chronic social defeat leads to a behavioral and physiological condition that resembles depressive states in human patients, including physiological dysfunction, anhedonia and motivational deficits. Lesions in the dorsal premammillary nucleus of the hypothalamus disrupt behavioral and neuroendocrine responses of animals exposed to one social defeat. In this project, we aim to inv...
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 25 |
| Citations | 503 |
| Cit./Article | 20.1 |
| Data from Web of Science | |
FATURI, C. B.; RANGEL, JR., M. J.; BALDO, M. V. C.; CANTERAS, N. S.. Functional mapping of the circuits involved in the expression of contextual fear responses in socially defeated animals. Brain Structure & Function, v. 219, n. 3, p. 931-946, MAY 2014. Web of Science Citations: 8. (11/02425-3)
LIMA, FERNANDO F. B.; SITA, LUCIANE V.; OLIVEIRA, AMANDA R.; COSTA, HELDER C.; DA SILVA, JOELCIMAR M.; MORTARA, RENATO A.; HAEMMERLE, CARLOS A. S.; XAVIER, GILBERTO F.; CANTERAS, NEWTON S.; BITTENCOURT, JACKSON C.. Hypothalamic melanin-concentrating hormone projections to the septo-hippocampal complex in the rat. Journal of Chemical Neuroanatomy, v. 47, p. 1-14, JAN 2013. Web of Science Citations: 11. (07/56975-9, 04/13849-5)
MOTTA, SIMONE C.; GUIMARAES, CIBELE CARLA; FURIGO, ISADORA CLIVATTI; SUKIKARA, MARCIA HARUMI; BALDO, MARCUS V. C.; LONSTEIN, JOSEPH S.; CANTERAS, NEWTON S.. Ventral premammillary nucleus as a critical sensory relay to the maternal aggression network. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 110, n. 35, p. 14438-14443, AUG 27 2013. Web of Science Citations: 12. (11/02425-3, 05/59286-4)
HAN, WENFEI; TELLEZ, LUIS A.; RANGEL, JR., MIGUEL J.; MOTTA, SIMONE C.; ZHANG, XIAOBING; PEREZ, ISAAC O.; CANTERAS, NEWTON S.; SHAMMAH-LAGNADO, SARA J.; VAN DEN POL, ANTHONY N.; DE ARAUJO, IVAN E.. Integrated Control of Predatory Hunting by the Central Nucleus of the Amygdala. Cell, v. 168, n. 1-2, p. 311+, JAN 12 2017. Web of Science Citations: 24. (14/26742-6, 12/24679-0)
XAVIER DE LIMA, MIGUEL ANTONIO; BALDO, MARCUS VINICIUS C.; CANTERAS, NEWTON SABINO. A role for the anteromedial thalamic nucleus in the acquisition of contextual fear memory to predatory threats. Brain Structure & Function, v. 222, n. 1, p. 113-129, JAN 2017. Web of Science Citations: 3. (14/05432-9, 13/04802-4)
SITA, LUCIANE VALERIA; DINIZ, GIOVANNE BARONI; CANTERAS, NEWTON SABINO; XAVIER, GILBERTO FERNANDO; BITTENCOURT, JACKSON CIONI. Effect of intrahippocampal administration of anti-melanin-concentrating hormone on spatial food-seeking behavior in rats. Peptides, v. 76, p. 130-138, FEB 2016. Web of Science Citations: 3. (04/13849-5)
CANTERAS, NEWTON S.; PAVESI, ELOISA; CAROBREZ, ANTONIO P.. Olfactory instruction for fear: neural system analysis. FRONTIERS IN NEUROSCIENCE, v. 9, AUG 6 2015. Web of Science Citations: 7. (14/05432-9)
DOS SANTOS, LUCELIA MENDES; BOSCHEN, SUELEN LUCIO; BORTOLANZA, MARIZA; DE OLIVEIRA, WAGNER FERNANDES; FURIGO, ISADORA CLIVATTI; MOTA-ORTIZ, SANDRA REGINA; DA CUNHA, CLAUDIO; CANTERAS, NEWTON SABINO. The role of the ventrolateral caudoputamen in predatory hunting. Physiology & Behavior, v. 105, n. 3, p. 893-898, FEB 1 2012. Web of Science Citations: 4. (05/59286-4)
DONATO, JR., JOSE; SILVA, RENATA J.; SITA, LUCIANE V.; LEE, SYANN; LEE, CHARLOTTE; LACCHINI, SILVIA; BITTENCOURT, JACKSON C.; FRANCI, CELSO R.; CANTERAS, NEWTON S.; ELIAS, CAROL F.. The Ventral Premammillary Nucleus Links Fasting-Induced Changes in Leptin Levels and Coordinated Luteinizing Hormone Secretion. JOURNAL OF NEUROSCIENCE, v. 29, n. 16, p. 5240-5250, APR 22 2009. Web of Science Citations: 68. (04/09638-9, 05/59286-4, 04/13849-5)
MOTA-ORTIZ, SANDRA REGINA; SUKIKARA, MARCIA HARUMI; FELICIO, LUCIANO FREITAS; CANTERAS, NEWTON SABINO. Afferent Connections to the Rostrolateral Part of the Periaqueductal Gray: A Critical Region Influencing the Motivation Drive to Hunt and Forage. NEURAL PLASTICITY, 2009. Web of Science Citations: 18. (05/59286-4)
DO MONTE, FABRICIO H. M.; CANTERAS, NEWTON SABINO; FERNANDES, DANIEL; ASSREUY, JAMIL; CAROBREZ, ANTONIO P.. New Perspectives on beta-Adrenergic Mediation of Innate and Learned Fear Responses to Predator Odor. JOURNAL OF NEUROSCIENCE, v. 28, n. 49, p. 13296-13302, DEC 3 2008. Web of Science Citations: 41. (05/59286-4)
DONATO, JR., J.; LEE, C.; RATRA, D. V.; FRANCI, C. R.; CANTERAS, N. S.; ELIAS, C. F.. LESIONS OF THE VENTRAL PREMAMMILLARY NUCLEUS DISRUPT THE DYNAMIC CHANGES IN KISS1 AND GNRH EXPRESSION CHARACTERISTIC OF THE PROESTRUS-ESTRUS TRANSITION. Neuroscience, v. 241, p. 67-79, JUN 25 2013. Web of Science Citations: 21. (05/59286-4)
SANDRA MARIA LIMA RIBEIRO; ZIRLENE ADRIANA DOS SANTOS; RENATA JULIANA DA SILVA; ELIANA LOUZADA; JOSÉ DONATO JUNIOR; JULIO TIRAPEGUI. Leptina: aspectos sobre o balanço energético, exercício físico e amenorréia do esforço. Arquivos Brasileiros de Endocrinologia e Metabologia, v. 51, n. 1, p. 11-24, Fev. 2007.
MOTTA, SIMONE C.; CAROBREZ, ANTONIO P.; CANTERAS, NEWTON S.. The periaqueductal gray and primal emotional processing critical to influence complex defensive responses, fear learning and reward seeking. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, v. 76, n. A, p. 39-47, MAY 2017. Web of Science Citations: 3. (14/05432-9)
BINDI, RICARDO PASSONI; BALDO, MARCUS VINICIUS C.; CANTERAS, NEWTON SABINO. Roles of the anterior basolateral amygdalar nucleus during exposure to a live predator and to a predator-associated context. Behavioural Brain Research, v. 342, p. 51-56, APR 16 2018. Web of Science Citations: 0. (14/05432-9, 15/00620-4)
VIELLARD, JULIETTE; BALDO, MARCUS VINICIUS C.; CANTERAS, NEWTON SABINO. Testing conditions in shock-based contextual fear conditioning influence both the behavioral responses and the activation of circuits potentially involved in contextual avoidance. Behavioural Brain Research, v. 315, p. 123-129, DEC 15 2016. Web of Science Citations: 0. (14/05432-9)
CANTERAS‚ N.S.; GOTO‚ M.. Fos-like immunoreactivity in the periaqueductal gray of rats exposed to a natural predator. Neuroreport, v. 10, n. 2, p. 413, 1999.
COMOLI‚ E.; RIBEIRO-BARBOSA‚ ER; CANTERAS‚ N.S.. Predatory hunting and exposure to a live predator induce opposite patterns of Fos immunoreactivity in the PAG. Behavioural Brain Research, v. 138, n. 1, p. 17-28, 2003.
KOBAN‚ M.; SITA‚ L.V.; LE‚ W.W.; HOFFMAN‚ G.E.. Sleep deprivation of rats: the hyperphagic response is real. Sleep, v. 31, n. 7, p. 927, 2008. (06/06289-9)
MOTTA, SIMONE CRISTINA; CANTERAS, NEWTON SABINO. Restraint stress and social defeat: What they have in common. Physiology & Behavior, v. 146, n. SI, p. 105-110, JUL 1 2015. Web of Science Citations: 5. (14/05432-9, 10/05905-3)
CAVALCANTE, JUDNEY CLEY; BITTENCOURT, JACKSON CIONI; ELIAS, CAROL FUZETI. Distribution of the neuronal inputs to the ventral premammillary nucleus of male and female rats. Brain Research, v. 1582, p. 77-90, SEP 25 2014. Web of Science Citations: 6. (05/59286-4, 04/13849-5)
MOTTA, SIMONE C.; GOTO, MARINA; GOUVEIA, FLAVIA V.; BALDO, MARCUS V. C.; CANTERAS, NEWTON S.; SWANSON, LARRY W.. Dissecting the brain's fear system reveals the hypothalamus is critical for responding in subordinate conspecific intruders. Proceedings of the National Academy of Sciences of the United States of America, v. 106, n. 12, p. 4870-4875, Mar. 2009. Web of Science Citations: 82. (05/59286-4)
MOTA-ORTIZ, SANDRA REGINA; SUKIKARA, MARCIA HARUMI; BITTENCOURT, JACKSON CIONI; BALDO, MARCUS VINICIUS; ELIAS, CAROL FUZETI; FELICIO, LUCIANO FREITAS; CANTERAS, NEWTON SABINO. The periaqueductal gray as a critical site to mediate reward seeking during predatory hunting. Behavioural Brain Research, v. 226, n. 1, p. 32-40, JAN 1 2012. Web of Science Citations: 16. (04/13849-5)
CARVALHO-NETTO, EDUARDO F.; MARTINEZ, RAQUEL C. R.; BALDO, MARCUS VINICIUS C.; CANTERAS, NEWTON SABINO. Evidence for the thalamic targets of the medial hypothalamic defensive system mediating emotional memory to predatory threats. NEUROBIOLOGY OF LEARNING AND MEMORY, v. 93, n. 4, p. 479-486, MAY 2010. Web of Science Citations: 16. (05/59286-4)
MARTINEZ, R. C.; CARVALHO-NETTO, E. F.; RIBEIRO-BARBOSA, E. R.; BALDO, M. V. C.; CANTERAS, N. S.. AMYGDALAR ROLES DURING EXPOSURE TO A LIVE PREDATOR AND TO A PREDATOR-ASSOCIATED CONTEXT. Neuroscience, v. 172, p. 314-328, JAN 13 2011. Web of Science Citations: 40. (05/59286-4)
PEDROSA, ROGERIO G.; DONATO, JR., JOSE; PIRES, IVANIR S.; TIRAPEGUI, JULIO. Leucine supplementation favors liver protein status but does not reduce body fat in rats during 1 week of food restriction. APPLIED PHYSIOLOGY NUTRITION AND METABOLISM, v. 35, n. 2, p. 180-183, APR 2010. Web of Science Citations: 9.
MARTINEZ, RAQUEL C. R.; CARVALHO-NETTO, EDUARDO F.; AMARAL, VANESSA C. S.; NUNES-DE-SOUZA, RICARDO L.; CANTERAS, NEWTON S.. Investigation of the hypothalamic defensive system in the mouse. Behavioural Brain Research, v. 192, n. 2, p. 185-190, Oct. 2008. (05/59286-4)
CEZARIO, A. F.; RIBEIRO-BARBOSA, E. R.; BALDO, M. V. C.; CANTERAS, N. S.. Hypothalamic sites responding to predator threats - the role of the dorsal premammillary nucleus in unconditioned and conditioned antipredatory defensive behavior. European Journal of Neuroscience, v. 28, n. 5, p. 1003-1015, Sept. 2008. Web of Science Citations: 55. (05/59286-4)
CANTERAS, NEWTON S.; KROON, JULIANA A. V.; DO-MONTE, FABRÍCIO H. M.; PAVESI, ELOISA; CAROBREZ, ANTONIO P.. Sensing danger through the olfactory system: the role of the hypothalamic dorsal premammillary nucleus. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, v. 32, n. 7, p. 1228-1235, Sept. 2008. (05/59286-4)
SANTOS, LUCÉLIA M. DOS; FERRO, MARCELO M.; MOTA-ORTIZ, SANDRA R.; BALDO, MARCUS V.; CUNHA, CLÁUDIO DA; CANTERAS, NEWTON S.. Effects of ventrolateral striatal inactivation on predatory hunting. Physiology & Behavior, v. 90, n. 4, p. 669-673, Mar. 2007. (05/59286-4)
FURIGO, I. C.; DE OLIVEIRA, W. F.; DE OLIVEIRA, A. R.; COMOLI, E.; BALDO, M. V. C.; MOTA-ORTIZ, S. R.; CANTERAS, N. S.. THE ROLE OF THE SUPERIOR COLLICULUS IN PREDATORY HUNTING. Neuroscience, v. 165, n. 1, p. 1-15, JAN 13 2010. Web of Science Citations: 20. (05/59286-4)
DONATO, JR., JOSE; CAVALCANTE, JUDNEY CLEY; SILVA, RENATA JULIANA; TEIXEIRA, ALINE STAVIN; BITTENCOURT, JACKSON CIONI; ELIAS, CAROL FUZETI. Male and female odors induce Fos expression in chemically defined neuronal population. Physiology & Behavior, v. 99, n. 1, p. 67-77, JAN 2010. Web of Science Citations: 31. (04/13849-5)
MIRANDA-PAIVA‚ C.M.; CANTERAS‚ N.S.; SUKIKARA‚ M.H.; NASELLO‚ A.G.; MACKOWIAK‚ I.I.; FELICIO‚ L.F.. Periaqueductal gray cholecystokinin infusions block morphine-induced disruption of maternal behavior. Peptides, v. 28, n. 3, p. 657-662, 2007.
BIAZOLI‚ C.E.; GOTO‚ M.; CAMPOS‚ A.M.P.; CANTERAS‚ N.S.. The supragenual nucleus: a putative relay station for ascending vestibular signs to head direction cells. Brain Research, v. 1094, n. 1, p. 138-148, 2006.