CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Guilherme Giannini Artioli in research grants and scholarships supported by FAPESP.
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Carnosine is an intracellular dipeptide endogenously synthesised in excitable tissues, especially in striated muscles. Carnosine can be obtained from diet via meat ingestion, although it displays very poor bioavailability due to the presence of carnosinases in the gastrointestinal tract and in the blood. Carnosine has several properties that confer therapeutic and ergogenic potential, amo…
Carnosine (ß-alanyl-L-histidine) is a dipeptide abundantly found in skeletal and cardiac muscles as well as in excitable tissues, although the physiological roles played by carnosine and its methylated analogues are still poorly understood. Evidence indicates that carnosine acts as a physico-chemical buffer during intense efforts, which is corroborated by the performance improvements obse…
Carnosine is a cytoplasmic dipeptide found in high concentrations in the skeletal muscle of both vertebrates and non-vertebrates, and is associated with muscle buffering, sensitivity of calcium release channels and/or calcium sensitivity of the contractile apparatus and scavenging of reactive oxygen species. It has been shown that the elevation of muscle carnosine concentrations through t…
Aldehyde dehydrogenase 2 (ALDH2) is an important enzyme involved in reactive aldehydes detoxification processes. About 40% of Asian population carry a mutation in the ALDH2 gene, which can reduce ALDH2 enzyme activity, thereby affecting reactive aldehydes detoxification. Recent evidence indicate that aldehydes from lipid peroxidation can impair satellite cell activation, which are myogeni…
Based on the potential of HMB supplementation to optimize strength and muscle mass gains from strength training, which may have important applications in the context of sport and health, and based on uncertainties regarding the pharmacological form with better bioavailability, This research project aims to analyze the bioavailability, absorption kinetics and clearance of blood HMB, as wel…
Increasing and maintaining muscle mass has been of great interest to many populations, which can be achieved through strength training and potentiated through dietary strategies such as increased/adequate protein intake and supplement intake. Phosphatidic Acid (PA) is a lipid messenger that has been shown to increase muscle protein synthesis due to stimulation of PI3K/AKT/mTOR signaling. …
Muscle strength is an important capacity for health and sports performance. It is well known that strength training (ST) is an important way to improve muscle strength and promote hypertrophy. Recent studies show that responses to ST are highly variable between subjects, as participants of similar characteristics undergoing the same training regimen display remarkably variability in stren…
(Only some records are available in English at this moment)
Muscle strength and size are important components of overall health and quality of life. Several intrinsic biological factors are involved in the regulation of muscle mass and muscle growth, including genetic characteristics, satellite cell function and myonuclei content. ACTN3 R577X and ALDH2 Glu487Lys are two genetic polymorphisms that have been shown to influence skeletal muscle biolog…
| 1 / 1 | Ongoing grants |
| 3 / 2 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 7 / 5 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 13 / 10 | All research grants and scholarships |
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