CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Instituto de Biociências (IBB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Ciências Biológicas Modalidade Médica from Universidade Estadual Paulista Júlio de Mesquita Filho (1998), master's at Microbiology from Universidade de São Paulo (2001) and ph.d. at Microbiology from Universidade Federal de São Paulo (2006). Has experience in Microbiology, focusing on Microbiology (Source: Lattes Curriculum)
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The species Escherichia albertii comprises the newest member of the genus Escherichia and is associated with sporadic cases, as well as outbreaks of diarrhea in several countries, including Brazil. One of the main characteristics of virulence observed in E. albertii isolates is the formation of the attaching and effacing lesion (AE), which is characterized by intimate bacteria adherence t…
Escherichia coli are characterized by harboring both commensal and / or symbiotic strains, as well as strains that are pathogenic to the intestinal and extraintestinal sites of humans and warm-blooded animals. This plurality of behavior is due, on the one hand, to the fact that most of its virulence determinants are encoded in mobile genetic elements and, on the other hand, the extreme pe…
(Only some records are available in English at this moment)
Collectively, Escherichia coli isolates associated with gastrointestinal tract infections are known as diarrheagenic E. coli (DEC), and based on their virulence factors, DEC can be subgrouped into six distinct pathotypes. From an epidemiological point of view, enteropathogenic E. coli (EPEC) and enteroaggregative E. coli (EAEC) are the most frequently DEC pathotypes isolated from stool sa…
Bacterial adherence to epithelial cells is an indispensable step in the pathogenicity, allowing the establishment of several pathogens in their hosts. Among the bacteria causing infections in the gastrointestinal tract, we can highlight the enteroaggregative Escherichia coli (EAEC) as an important agent of acute and persistent diarrhea. The main phenotypic feature of EAEC isolates is thei…
Enteropathogenic Escherichia coli (EPEC) is one of the six pathotypes of diarrheagenic E. coli (DEC). EPEC is defined by the presence of a pathogenicity island called the locus of enterocyte effacement (LEE region). The LEE region harbors a set of genes responsible for encoding proteins involved in the biogenesis of a type 3 secretion system, effector proteins, and the afimbrial adhesin i…
Biofilm formation is a key virulence factor for the pathogenesis of many bacteria, allowing them to adhere in distinct surfaces, escape from antimicrobial drugs and evade the host's immune system. Biofilm formation depends on several factors, among which the adhesins are considered essential for pathogen attachment to biotic and abiotic surfaces. Among the pathogens that form biofilm, we …
(Only some records are available in English at this moment)
A central virulence mechanism of enteropathogenic Escherichia coli (EPEC) is the formation of attaching and effacing (A/E) lesions on the surface of infected eukaryotic cells, mediated by the translocation of several effector proteins via a type III secretion system (T3SS). The proteins responsible for assembling the T3SS are encoded by genes located within the locus of enterocyte effacem…
Although described as diarrheagenic Escherichia coli, several studies in the literature are accumulating evidence that enteroaggregative E. coli (EAEC) isolates can be associated with extraintestinal infections, such as bacteremia and urinary tract infections. Here we analyzed the presence of the five extraintestinal pathogenic E. coli (ExPEC) classificatory genes (papA and/or papC, afa/d…
Atypical enteropathogenic E.coli (aEPEC) are one of the most prevalent diarrheagenic E. coli pathotype implicated as a cause of diarrhea in children and adults worldwide. The hallmark of aEPEC infection is the formation of a lesion termed attaching and effacing (AE) lesion, which promotes the intimate adherence of the bacteria to the host cells, erasure of brush border microvilli and form…