CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. Instituto de Ciência e Tecnologia (ICT) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Odontologia from Universidade Estadual de Londrina (1993), master's at Biologia e Patologia Buco Dental from Universidade Estadual de Campinas (2001) and ph.d. at Estomatopatologia from Faculdade de Odontologia de Piracicaba Unicamp (2004). Has experience in Odontology, acting on the following subjects: síndrome, carcinoma, esmalte, odontologia and cisto odontogênico. (Source: Lattes Curriculum)
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Objectives: Tobacco has been associated with the development of oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC). This study aimed to evaluate the in vitro and in vivo changes caused by the carcinogen 4-nitroquinoline 1-oxide (4NQO), simulating smoking conditions. Materials and Methods: In the in vitro study, normal keratinocytes were exposed to 1.3 µM and 2.6 µM concentratio…
Squamous cell carcinoma (SCC) in the head and neck is one of the most common malignancies in the world. One way of preventing it is by early detection and treatment of oral potentially malignant lesions (OPML). One of the most common OPML is oral leukoplakia (OLP); its malignant transformation rate is related to its clinical form and the presence or absence of epithelial dysplasia. To dat…
Introduction: Laryngeal papillomatosis is a benign neoplasia divided into two groups: juvenile and adult laryngeal papillomatosis. It is caused by the human papillomavirus (HPV). HPV types 6 and 11 are related to its etiology; however, the possible viral co-infection has been suggested in lesions of the head and neck region. Objectives: To describe the clinical and microscopic characteris…
Oral squamous cell carcinoma (OSCC) affects mainly patients between the 5th and 6th decades of life, being relatively rare in the young (d40 years). There is no report about the protein expression of drug metabolizing enzymes in OSCC in this group. The aim of this study is evaluate the protein expression of CYP1A1, CYP1B1, ALDH-1 and ALDH-2 by Tissue Microarray (TMA) technique. Forty prim…
(Only some records are available in English at this moment)
Oral squamous cell carcinoma (OSCC) is the most prevalent subtype of head andneck squamous cell carcinoma (HNSCC), predominantly affecting men, smokers,and chronic alcohol consumers, primarily between the fifth and sixth decades of life.However, its incidence is increasing among young adults. This project aims todevelop and characterize tumor-derived organoids from HNSCC patients,comparin…
Alcohol, tobacco and the presence of potentially malignant disorders (PMD), as leukoplakia, are important risks for the development of a squamous cell carcinoma (SCC). Artemisinin (ART) and cisplatin (CIS) have evidence that they may be useful to prevent the progression of leukoplakia into a SCC, thus, we aim to evaluate if interventions with ART and CIS are effective in the treatment o…
This study evaluates the comparison of the PD1 and PD-L1 protein signaling pathway in Actinic Cheilits (AQ), a lesion that can progress to Squamous Cell Carcinoma (SCLC). Material and methods: 30 cases of lower lip biopsies with diagnosis of AK and 30 of CCEL will be selected, obtained from the Oral Pathology Laboratory of the Institute of Science and Technology of São José dos Campos/UNE…
Oral Squamous Cell Carcinoma (OSCC) in the head and neck region is one of the most common malignant neoplasms in the world. Early detection and treatment of potentially malignant lesions (PML) have preventive potential in relation to OSCC. One of the most common OLP is oral leukoplakia (OPL), which has a rate of malignant transformation related to its clinical form and the presence or abs…
(Only some records are available in English at this moment)