CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Bauru. Faculdade de Ciências (FC) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Bacharelado em Química from Universidade Estadual Paulista Júlio de Mesquita Filho (2008). , acting on the following subjects: comportamento térmico, thermal behaviour, mgnetic nanoparticle, bivalent transition metals and iron oxide. (Source: Lattes Curriculum)
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Currently, many drugs marketed or under development have problems with low aqueous solubility and inadequate dissolution rate, leading to bioavailability problems. Nanotechnology has been widely developed and applied to improve the solubility of active pharmaceutical ingredients (APIs). Cocrystals have also been receiving much attention in the design and development of drugs, since cocrys…
The low aqueous solubility and low oral bioavailability of the active pharmaceutical ingredients (APIs) are the main constraints during the development of new products. Several approaches have been used to improve the aqueous solubility of poorly soluble drugs, but the success of such approaches depends on the physical and chemical nature of the molecules being developed. The co-crystalli…
The research infrastructure investment plan of the School of Sciences, Bauru - UNESP, is presented within the resources made available through the Institutional Technical Reserve of FAPESP, referring to 2018. The plan seeks to meet the demands of the laboratories and researchers of the unit, especially those who have or had research projects funded by FAPESP. The items listed in this plan…
Active pharmaceutical ingredients have a therapeutic activity whose efficacy depends on their physicochemical properties. Mefenamic acid (MFA) is a drug used to treat muscle pain, arthritis and dysmenorrhea. Although it is widely used, it has low aqueous solubility. This condition is seen as unfavorable since higher dosages of the drug may be required to achieve the desired therapeutic ef…
Nanotechnology has been arousing great interest in the area of developing new materials, mainly in the improvement of nanomaterials for pharmaceutical applications. The association of nanotechnology with cocrystallization constitutes a new class of materials called nano-cocrystals, which stands out as an area of research on the rise, since the combination of crystal engineering with nanot…
Viral diseases, from common respiratory infections to serious illnesses such as AIDS, pose public health challenges. The use of antiretrovirals is essential to contain these diseases, offering a better quality of life to patients. Protease inhibitors (PIs) are a class of antiretrovirals used to treat HIV, but they have disadvantages such as low bioavailability, which requires administrati…
(Only some records are available in English at this moment)
Cholesterol is a lipid that performs important functions in the human body, for example, as a structural component of cell membranes, synthesis of hormones, and synthesis of vitamin D. However, nowadays, high cholesterol is one of the biggest problems that public health is facing, as it is associated with metabolic and neurological diseases, such as Alzheimer's, diabetes and hypertension.…
Envenomation by snakebite is a relevant global health problem, considering the thousands of annual cases resulting from these accidents. Many medicinal plants have components that inhibit the effects of phospholipase A2 (PLA2) protein toxins found in snake venoms, especially polyphenolic acids, which also have several actions, such as antiviral, antibacterial, among others. However, these…
Cocrystallization is an approach that aims to improve the physicochemical properties of drugs already on the market and of potential drugs. Cocrystals are formed when there are intermolecular interactions between the drug and coformer molecules involved in the synthesis, and the interactions formed do not interfere with the therapeutic activity of the drug. Hereby, this project aims the s…
(Only some records are available in English at this moment)
Gemfibrozil is a widely used drug for the treatment of dyslipidemias, being effective in reducing blood levels of triglycerides and fatty acids, in addition to exhibiting cardioprotective effects. However, gemfibrozil presents limitations in absorption and therapeutic efficacy due to its low solubility in aqueous media, classified as a Biopharmaceutical Classification System (BCS) Class I…
Snake bites are a global health problem, responsible for millions of cases and a large number of deaths. As a result, new ways of inhibiting the protein phospholipase A2 (PLA2) toxin were sought, thus it was planned that compounds found in medicinal plants such as polyphenols are effective in deactivating the poison. Caffeic acid is a polyphenol with antimicrobial, anti-inflammatory, anti…
Currently, several drugs that have low aqueous solubility are found in circulation, this deficiency reduces the absorption of the drug in the body and causes them to be administered in higher daily doses and for a longer period of time, which can cause adverse effects to patients. In view of this, the formation of pharmaceutical cocrystals is an approach that aims to improve the physicoch…
| 1 / 1 | Ongoing grants |
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| 4 / 4 | Ongoing scholarships in Brazil |
| 4 / 4 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 2 / 2 | Completed scholarships abroad |
| 14 / 14 | All research grants and scholarships |
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