Abstract
Classical Hodgkin Lymphoma (CHL) is a lymphoproliferative malignancy of B lymphocytes associated with Epstein-Barr virus (EBV) infection and modulated by proinflammatory cytokines and chemokines and growth factors. The production and secretion of these inflammatory mediators by Hodgkin and Reed-Sternberg cells in the tumor microenvironment can lead to CHL progression. This clinical progre…