CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. Instituto de Biociências, Letras e Ciências Exatas (IBILCE) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Bachelor's at Biology from Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP (1968), master's at Biologia Celular from Universidade de São Paulo - USP 1987) and doctorate at Histology from Universidade de São Paulo - USP(1993). He is currently full professor at Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP. Has experience in Morphology, focusing on Histology, acting on the following subjects: inflammation cells (mast cells and leukocytes) and annexin 1 and galectin 1 proteins, . (Source: Lattes Curriculum)
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Chronic, non-resolving inflammation is a major contributor to impaired wound healing in diabetes. Annexin A1 (AnxA1), a pro-resolving mediator, and its mimetic peptide Ac2-26 have demonstrated therapeutic potential in modulating inflammatory responses. In this study, we evaluated the effects of topical Ac2-26 hydrogel in a streptozotocin-induced dia-betic wound model. Treatment significan…
Annexin A1 (ANXA1) is a 37 kDa protein that exhibits calcium and membrane phospholipid binding sites and is involved in the inhibition of glucocorticoid-induced eicosanoid and phospholipase A2 synthesis, which gives antiinflammatory properties to this protein. Several studies have shown the protective effect of ANXA1 on acute and chronic inflammatory processes in response to infection and…
Biocompatibility of two newly developed porcine skin scaffolds was assessed after 3, 14, 21 and 90 days of implantation in rats. Both scaffolds showed absence of cells, preservation of ECM and mechanical properties comparable to non-decellularised skin before implantation. Host cell infiltration was much prominent on both scaffolds when compared to Permacol (surgical control). At day 3, t…
(Only some records are available in English at this moment)
Studies that allow the understanding of mechanisms that play a role in placental pathophysiology are extremely relevant and may help to understand the many complications that compromise pregnancy and fetal health. Known factors that may compromise the development of placenta and, consequently, the fetus include: nutrient deficiency, glycemic disorders, viral and bacterial infections, hype…
Angiogenesis is the formation of new blood vessels from pre-existing vasculature, and the vascular endothelial growth factor (VEGF) is a key regulator in this process, being a survival factor for endothelial cells, stimulating the origin of new microvascular network. The angiogenesis process is extremely necessary for the success of transplants, regeneration and repair of damaged tissues,…
(Only some records are available in English at this moment)
Studies that allow the understanding of the mechanisms that play a role in placental pathophysiology are extremely relevant and may help to understand the many complications that compromise pregnancy and fetal health. Viral infections during pregnancy have been demonstrated to cause spontaneous abortions, stillbirth, fetal infection, intrauterine growth restriction (IUGR), preterm prematu…
The clinical impact of various lesions such as loss of skin due to non-healing ulcers, abdominal wall defects resulting from trauma, extensive tumor resection, necrotizing infections, or extensive burns associated with limited use of autografts, has led an enormous advance in the development of tissue-engineered skin derivatives or acellular matrices. Designed as skin substitutes, both ep…
(Only some records are available in English at this moment)