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Geraldo Aleixo da Silva Passos Júnior

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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP)  (Instituição-sede da última proposta de pesquisa)
País de origem: Brasil

Graduated in Biology from UNESP State University São Paulo, Brazil (1980-83), Master MSc (1984-86) and PhD (1986-88) in Biochemistry from Ribeirão Preto Medical School (FMRP), University of São Paulo, USP, Brazil. His postdoctoral studies were conducted at the Molecular Genetics Institute of Montpellier (CNRS), France (1992-94) with sequencing and physical mapping of the human immunoglobulin lambda locus on chromosome 22q11.2. He is currently Associate Professor (Professor of Genetics and Molecular Biology) at School of Dentistry of Ribeirão Preto (FORP-USP). In the late 1990´s he organized one of the first microarray and transcriptome analysis labs in Brazil (FMRP). Coordinator of the Lab. of Genetics and Molecular Biology at FORP-USP and of the Molecular Immunogenetics Group at FMRP-USP (sites.usp.br/imunogenetica). Adviser of Master and PhD students in Endodontics (FORP-USP), Genetics (FMRP-USP) and Immunology (FMRP-USP). Vice-Coordinator of the Doctoral Program in Genetics (FMRP-USP 2016-18). He was the coordinator of two FAPESP Thematic Projects and in the past five years he coordinates the following projects: 1) Transcriptome of medullary thymic epithelial cells (mTECs) using microarrays and RNA-Seq (NGS) (FAPESP), 2) CAPES (PVE within the "Ciência sem Fronteiras" Science without Borders Program) in agreement with the Université Aix-Marseille and INSERM (Lab. U1090, Marseille, France), 3) CNPq-National Institutes of Health (NIH, USA)-University of Georgia in Athens, GA, USA. Member of the Board of Academic Editors of Plos One and is Associate Editor of Frontiers in Immunology. He has experience in molecular genetics, focusing mainly on the following topics: functional genomics (transcriptome analysis) of the immune system (thymus ontogeny, Aire gene, microRNAs and autoimmune diseases). He also works on projects on gene expression during differentiation of human dental pulp mesenchymal stem cells. For this, he uses mainly the Crispr-Cas9-based genome editing, microarrays (oligo-microarrays and microRNA-arrays), RNA-Seq and bioinformatics programs such as cluster-tree view (hierarchical clustering based on gene expression signatures), SAM, RankProducts (analysis of microarray data), RNA-Hybrid and GenMir++ (network interaction between microRNAs and mRNAs). He was the adviser of two PhD theses awarded by CAPES Ministry of Education: in 2008 he received the CAPES Thesis Award and in 2010 the CAPES Thesis Honor in Genetics. (Fonte: Currículo Lattes)

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Publicações resultantes de Auxílios e Bolsas sob responsabilidade do(a) pesquisador(a) (34)

(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)

Publicações19
Citações180
Cit./Artigo9,5
Dados do Web of Science

PASSOS, GERALDO ALEIXO; MENDES-DA-CRUZ, DANIELLE AREAS; OLIVEIRA, ERNNA HERIDA. The thymic orchestration involving Aire, miRNAs, and cell-cell interactions during the induction of central tolerance. FRONTIERS IN IMMUNOLOGY, v. 6, . Citações Web of Science: 10. (13/17481-1, 13/08216-2)

XAVIER, DANILO J.; TAKAHASHI, PAULA; EVANGELISTA, ADRIANE F.; FOSS-FREITAS, MARIA C.; FOSS, MILTON C.; DONADI, EDUARDO A.; PASSOS, GERALDO A.; SAKAMOTO-HOJO, ELZA T.. Assessment of DNA damage and mRNA/miRNA transcriptional expression profiles in hyperglycemic versus non-hyperglycemic patients with type 2 diabetes mellitus. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, v. 776, n. SI, p. 98-110, . Citações Web of Science: 10. (10/12069-7, 08/56594-8)

PASSOS, GERALDO A.; SPECK-HERNANDEZ, CESAR A.; ASSIS, AMANDA F.; MENDES-DA-CRUZ, DANIELLA A.. Update on Aire and thymic negative selection. IMMUNOLOGY, v. 153, n. 1, p. 10-20, . Citações Web of Science: 0. (13/17481-1)

SPECK-HERNANDEZ, CESAR A.; ASSIS, AMANDA F.; FELICIO, RAFAELA F.; COTRIM-SOUSA, LARISSA; PEZZI, NICOLE; LOPES, GABRIEL S.; BOMBONATO-PRADO, KARINA F.; GIULIATTI, SILVANA; PASSOS, GERALDO A.. Aire Disruption Influences the Medullary Thymic Epithelial Cell Transcriptome and Interaction With Thymocytes. FRONTIERS IN IMMUNOLOGY, v. 9, . Citações Web of Science: 0. (13/17481-1)

FORNARI, THAIS A.; DONATE, PAULA B.; ASSIS, AMANDA F.; MACEDO, CLAUDIA; SAKAMOTO-HOJO, ELZA T.; DONADI, EDUARDO A.; PASSOS, GERALDO A.. Comprehensive Survey of miRNA-mRNA Interactions Reveals That Ccr7 and Cd247 (CD3 zeta) are Posttranscriptionally Controlled in Pancreas Infiltrating T Lymphocytes of Non-Obese Diabetic (NOD) Mice. PLoS One, v. 10, n. 11, . Citações Web of Science: 7. (13/08216-2, 08/56594-8)

XAVIER, DANILO J.; TAKAHASHI, PAULA; MANOEL-CAETANO, FERNANDA S.; FOSS-FREITAS, MARIA C.; FOSS, MILTON C.; DONADI, EDUARDO A.; PASSOS, GERALDO A.; SAKAMOTO-HOJO, ELZA T.. One-week intervention period led to improvements in glycemic control and reduction in DNA damage levels in patients with type 2 diabetes mellitus. Diabetes Research and Clinical Practice, v. 105, n. 3, p. 356-363, . Citações Web of Science: 4. (10/12069-7, 10/00932-2, 08/56594-8)

DERNOWSEK, JANAINA A.; PEREIRA, MILENA C.; FORNARI, THAIS A.; MACEDO, CLAUDIA; ASSIS, AMANDA F.; DONATE, PAULA B.; BOMBONATO-PRADO, KARINA F.; PASSOS-BUENO, MARIA RITA; PASSOS, GERALDO A.. Posttranscriptional Interaction Between miR-450a-5p and miR-28-5p and STAT1 mRNA Triggers Osteoblastic Differentiation of Human Mesenchymal Stem Cells. Journal of Cellular Biochemistry, v. 118, n. 11, p. 4045-4062, . Citações Web of Science: 3. (07/57658-7)

OLIVEIRA, ERNNA H.; MACEDO, CLAUDIA; COLLARES, CRISTHIANNA V.; FREITAS, ANA CAROLINA; DONATE, PAULA BARBIM; SAKAMOTO-HOJO, ELZA T.; DONADI, EDUARDO A.; PASSOS, GERALDO A.. Aire Downregulation Is Associated with Changes in the Posttranscriptional Control of Peripheral Tissue Antigens in Medullary Thymic Epithelial Cells. FRONTIERS IN IMMUNOLOGY, v. 7, . Citações Web of Science: 3. (13/17481-1, 08/56594-8)

MACEDO, CLAUDIA; OLIVEIRA, ERNNA H.; ALMEIDA, RENATA S.; DONATE, PAULA B.; FORNARI, THAIS A.; PEZZI, NICOLE; SAKAMOTO-HOJO, ELZA T.; DONADI, EDUARDO A.; PASSOS, GERALDO A.. Aire-dependent peripheral tissue antigen mRNAs in mTEC cells feature networking refractoriness to microRNA interaction. Immunobiology, v. 220, n. 1, p. 93-102, . Citações Web of Science: 6. (13/17481-1, 13/08216-2, 08/56594-8)

PEZZI, NICOLE; ASSIS, AMANDA FREIRE; COTRIM-SOUSA, LARISSA COTRIM; LOPES, GABRIEL SARTI; MOSELLA, MARITZA SALAS; LIMA, DJALMA SOUSA; BOMBONATO-PRADO, KARINA F.; PASSOS, GERALDO ALEIXO. Aire knockdown in medullary thymic epithelial cells affects Aire protein, deregulates cell adhesion genes and decreases thymocyte interaction. Molecular Immunology, v. 77, p. 157-173, . Citações Web of Science: 4. (13/17481-1)

PASSOS‚ G.A.S.; PROENÇA PICANÇO‚ V.. Frequency of the δ< i> ccr 5 deletion allele in the urban Brazilian population. Immunology Letters, v. 61, n. 2, p. 205-207, . (97/07664-7, 97/03134-3)

EVANGELISTA, ADRIANE F.; COLLARES, CRISTHIANNA V. A.; XAVIER, DANILO J.; MACEDO, CLAUDIA; MANOEL-CAETANO, FERNANDA S.; RASSI, DIANE M.; FOSS-FREITAS, MARIA C.; FOSS, MILTON C.; SAKAMOTO-HOJO, ELZA T.; NGUYEN, CATHERINE; et al. Integrative analysis of the transcriptome profiles observed in type 1, type 2 and gestational diabetes mellitus reveals the role of inflammation. BMC MEDICAL GENOMICS, v. 7, . Citações Web of Science: 9. (10/12069-7, 10/05622-1, 10/00932-2, 08/56594-8)

TAKAHASHI, PAULA; XAVIER, DANILO J.; EVANGELISTA, ADRIANE F.; MANOEL-CAETANO, FERNANDA S.; MACEDO, CLAUDIA; COLLARES, CRISTHIANNA V. A.; FOSS-FREITAS, MARIA C.; FOSS, MILTON C.; RASSI, DIANE M.; DONADI, EDUARDO A.; et al. MicroRNA expression profiling and functional annotation analysis of their targets in patients with type 1 diabetes mellitus. Gene, v. 539, n. 2, p. 213-223, . Citações Web of Science: 23. (10/12069-7, 10/00932-2, 10/05622-1, 08/56594-8)

DONATE, PAULA B.; FORNARI, THAIS A.; MACEDO, CLAUDIA; CUNHA, THIAGO M.; NASCIMENTO, DANIELE C. B.; SAKAMOTO-HOJO, ELZA T.; DONADI, EDUARDO A.; CUNHA, FERNANDO Q.; PASSOS, GERALDO A.. T Cell Post-Transcriptional miRNA-mRNA Interaction Networks Identify Targets Associated with Susceptibility/Resistance to Collagen-induced Arthritis. PLoS One, v. 8, n. 1, . Citações Web of Science: 10. (08/56594-8)

MANOEL-CAETANO, FERNANDA S.; XAVIER, DANILO J.; EVANGELISTA, ADRIANE F.; TAKAHASHI, PAULA; COLLARES, CRISTHIANNA V.; PUTHIER, DENIS; FOSS-FREITAS, MARIA C.; FOSS, MILTON C.; DONADI, EDUARDO A.; PASSOS, GERALDO A.; et al. Gene expression profiles displayed by peripheral blood mononuclear cells from patients with type 2 diabetes mellitus focusing on biological processes implicated on the pathogenesis of the disease. Gene, v. 511, n. 2, p. 151-160, . Citações Web of Science: 20. (10/12069-7, 10/05622-1, 10/00932-2, 08/56594-8)

SANDRIN-GARCIA‚ P.; MACEDO‚ C.; MARTELLI‚ LR; RAMOS‚ ES; GUION-ALMEIDA‚ ML; RICHIERI-COSTA‚ A.; PASSOS‚ GAS. Recurrent 22q11. 2 deletion in a sibship suggestive of parental germline mosaicism in velocardiofacial syndrome. Clinical Genetics, v. 61, n. 5, p. 380-383, . (98/05584-9, 98/09789-4, 99/09051-8, 97/13599-3)

MACEDO‚ C.; MORAES JUNTA‚ C.; PASSOS‚ G.A.S.. Onset of T-cell receptor V [beta] 8.1 and D [beta] 2.1 V (D) J recombination during thymus development of inbred mouse strains. Immunology Letters, v. 69, n. 3, p. 371-373, . (98/05584-9, 98/09789-4)

DA SILVA‚ M.I.; PASSOS‚ G.A.S.. The human immunoglobulin variable lambda locus IGLV9 gene is a monomorphic marker in the urban Brazilian population. Immunology Letters, v. 69, n. 3, p. 369-370, . (98/05584-9, 98/09789-4)

MORAES JUNTA‚ C.; PASSOS‚ G.A.S.. Genomic EcoRI polymorphism and cosmid sequencing reveal an insertion/deletion and a new IGLV5 allele in the human immunoglobulin lambda variable locus (22q11. 2/IGLV). IMMUNOGENETICS, v. 55, n. 1, p. 10-15, . (98/05584-9, 98/09789-4, 96/07847-1)

MELLO, STEPHANO S.; FACHIN, ANA L.; JUNTA, CRISTINA M.; SANDRIN-GARCIA, PAULA; DONADI, EDUARDO A.; PASSOS, GERALDO A. S.; SAKAMOTO-HOJO, ELZA T.. Delayed Effects of Exposure to a Moderate Radiation Dose on Transcription Profiles in Human Primary Fibroblasts. Environmental and Molecular Mutagenesis, v. 52, n. 2, p. 117-129, . Citações Web of Science: 6. (99/12135-9, 02/07314-6)

FACHIN, ANA LUCIA; MELLO, STEPHANO SPANO; SANDRIN-GARCIA, PAULA; JUNTA, CRISTINA MORAES; GHILARDI-NETTO, THOMAZ; DONADI, EDUARDO ANTONIO; DA SILVA PASSOS, GERALDO ALEIXO; SAKAMOTO-HOJO, ELZA TIEMI. Gene Expression Profiles in Radiation Workers Occupationally Exposed to Ionizing Radiation. JOURNAL OF RADIATION RESEARCH, v. 50, n. 1, p. 61-71, . Citações Web of Science: 39. (99/12135-9, 02/07314-6, 01/10995-2)

BASSI, C. L.; MELLO, S. S.; CARDOSO, R. S.; GODOY, P. D. V.; FACHIN, A. L.; JUNTA, C. M.; SANDRIN-GARCIA, P.; CARLOTTI, C. G.; FALCAO, R. P.; DONADI, E. A.; et al. Transcriptional changes in U343 MG-a glioblastoma cell line exposed to ionizing radiation. HUMAN & EXPERIMENTAL TOXICOLOGY, v. 27, n. 12, p. 919-929, . Citações Web of Science: 13. (99/12135-9, 04/15611-6)

MAGALHÃES, DANIELLE A. R.; MACEDO, CLAUDIA; JUNTA, CRISTINA M.; MELLO, STEPHANO S.; MARQUES, MÁRCIA M. C.; CARDOSO, RENATO S.; SAKAMOTO-HOJO, ELZA T.; DONADI, EDUARDO A.; PASSOS, GERALDO A. S.. Hybridization signatures during thymus ontogeny reveals modulation of genes coding for T-cell signaling proteins. Molecular Immunology, v. 42, n. 9, p. 1043-1048, . (99/12135-9, 01/08278-0)

TREVISAN‚ G.L.; RASSI‚ D.M.; BAIÃO‚ A.M.T.; SANDRIN-GARCIA‚ P.; MELLO‚ S.S.; TAMIA-FERREIRA‚ M.C.; JUNTA‚ C.M.; FACHIN‚ A.L.; MARQUES‚ M.; SAKAMOTO-HOJO‚ E.T.; et al. Using cDNA microarrays to identify human CD19+ B cell gene products (ESTs) originated from systemic lupus erythematosus susceptibility loci. AUTOIMMUNITY REVIEWS, v. 5, n. 5, p. 319-323, . (99/12135-9, 00/11793-1)

RASSI‚ D.M.; JUNTA‚ C.M.; FACHIN‚ A.N.A.L.; SANDRIN-GARCIA‚ P.; MELLO‚ S.S.; FERNANDES‚ A.N.A.P.M.; DEGHAIDE‚ N.N.H.S.; FOSS-FREITAS‚ M.C.; FOSS‚ M.C.; SAKAMOTO-HOJO‚ E.T.; et al. Is HLA Class II Profile Relevant for the Study of Large-Scale Differentially Expressed Genes in Type 1 Diabetes Mellitus Patients?. Annals of the New York Academy of Sciences, v. 1079, n. 1, p. 305-309, . (99/12135-9, 01/04101-9)

RASSI‚ D.M.; JUNTA‚ C.M.; FACHIN‚ A.N.A.L.; SANDRIN-GARCIA‚ P.; MELLO‚ S.; MARQUES‚ M.; FERNANDES‚ A.N.A.P.M.; FOSS-FREITAS‚ M.C.; FOSS‚ M.C.; SAKAMOTO-HOJO‚ E.T.; et al. Metabolism genes are among the differentially expressed ones observed in lymphomononuclear cells of recently diagnosed type 1 diabetes mellitus patients. Annals of the New York Academy of Sciences, v. 1079, n. 1, p. 171-176, . (99/12135-9, 01/04101-9)

PEREIRA‚ E.; TAMIA-FERREIRA‚ M.C.; CARDOSO‚ R.S.; MELLO‚ S.S.; SAKAMOTO-HOJO‚ E.T.; PASSOS‚ G.A.S.; DONADI‚ E.A.. Immunosuppressive therapy modulates T lymphocyte gene expression in patients with systemic lupus erythematosus. Immunology, v. 113, n. 1, p. 99-105, . (99/12135-9)

SILVA‚ G.L.; JUNTA‚ C.M.; MELLO‚ S.S.; GARCIA‚ P.S.; RASSI‚ D.M.; SAKAMOTO-HOJO‚ E.T.; DONADI‚ E.A.; PASSOS‚ G.A.S.. Profiling Meta-Analysis Reveals Primarily Gene Coexpression Concordance between Systemic Lupus Erythematosus and Rheumatoid Arthritis. Annals of the New York Academy of Sciences, v. 1110, n. 1, p. 33-46, . (99/12135-9)

CARDOSO‚ R.S.; JUNTA‚ C.M.; MACEDO‚ C.; MAGALHÃES‚ D.A.R.; SILVEIRA‚ E.L.V.; PAULA‚ M.O.; MARQUES‚ M.; MELLO‚ S.S.; ZÁRATE-BLADÉS‚ C.R.; NGUYEN‚ C.; et al. Hybridization signatures of gamma-irradiated murine fetal thymus organ culture (FTOC) reveal modulation of genes associated with T-cell receptor V (D) J recombination and DNA repair. Molecular Immunology, v. 43, n. 5, p. 464-472, . (99/12135-9, 00/09994-9)

SOUSA CARDOSO‚ R.; MAGALHÃES‚ D.A.R.; BAIÃO‚ A.M.T.; JUNTA‚ C.M.; MACEDO‚ C.; MARQUES‚ M.; SAKAMOTO-HOJO‚ E.T.; DONADI‚ E.A.; PASSOS‚ G.A.S.. Onset of promiscuous gene expression in murine fetal thymus organ culture. Immunology, v. 119, n. 3, p. 369-375, . (99/12135-9)

FACHIN‚ A.L.; MELLO‚ S.S.; SANDRIN-GARCIA‚ P.; JUNTA‚ C.M.; DONADI‚ E.A.; PASSOS‚ G.A.S.; SAKAMOTO-HOJO‚ E.T.. Gene expression profiles in human lymphocytes irradiated in vitro with low doses of gamma rays. RADIATION RESEARCH, v. 168, n. 6, p. 650-665, . (99/12135-9, 02/07314-6, 01/10995-2)

COLLARES, C. V. A.; EVANGELISTA, A. F.; XAVIER, D. J.; TAKAHASHI, P.; ALMEIDA, R.; MACEDO, C.; MANOEL-CAETANO, F.; FOSS, M. C.; FOSS-FREITAS, M. C.; RASSI, D. M.; et al. Transcriptome meta-analysis of peripheral lymphomononuclear cells indicates that gestational diabetes is closer to type 1 diabetes than to type 2 diabetes mellitus. MOLECULAR BIOLOGY REPORTS, v. 40, n. 9, p. 5351-5358, . Citações Web of Science: 9. (10/12069-7, 10/05622-1, 10/00932-2, 08/56594-8)

R.G.P. QUEIROZ; M.C. TAMIA-FERREIRA; I.F. CARVALHO; F.C. PETEAN; G.A.S. PASSOS. Association between EcoRI fragment-length polymorphism of the immunoglobulin lambda variable 8 (IGLV8) gene family with rheumatoid arthritis and systemic lupus erythematosus. Brazilian Journal of Medical and Biological Research, v. 34, n. 4, p. 525-528, . (98/09789-4, 98/05584-9)

CARMINATI, PATRICIA OLIVEIRA; MELLO, STEPHANO SPANO; FACHIN, ANA LUCIA; JUNTA, CRISTINA MORAES; SANDRIN-GARCIA, PAULA; CARLOTTI, CARLOS GILBERTO; DONADI, EDUARDO ANTONIO; SILVA PASSOS, GERALDO ALEIXO; SAKAMOTO-HOJO, ELZA TIEMI. Alterations in gene expression profiles correlated with cisplatin cytotoxicity in the glioma U343 cell line. GENETICS AND MOLECULAR BIOLOGY, v. 33, n. 1, p. 159-168, . Citações Web of Science: 4. (99/12135-9, 04/15611-6)

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