The agreement with CNPq - National Council for Scientific and Technological Development aims to implement the Program of Support for Excellence Centers - Pronex, in the State of São Paulo.
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The present project aims the study of intermolecular interactions in transition metal complexes with organic ligands, with the objective of establishing the mechanism of action of these compounds as potential anticancer drugs, antituberculosis, antichagasic or antimalarial drugs. These studies consist of several steps that include the synthesis of the compounds, their spectroscopic charac…
The present project aims the study of intermolecular interactions in transition metal complexes with organic ligands, with the objective of establishing the mechanism of action of these compounds as potential anticancer drugs, antituberculosis, antichagasic or antimalarial drugs. These studies consist of several steps that include the synthesis of the compounds, their spectroscopic charac…
Epilepsy affects about 1% to 2% of world population, and the mesial temporal lobe epilepsy (TLE) the most frequent, representing 40% of patients, these are often refractory to medicaI treatment. One of the most used tools to try to understand the pathophysiology of MTLE is induced animal models. Despite several animal models currently available and widely studied, most of these lesions pr…
The objective of the Project is to elucidate neural mechanisms that process autonomic information associated with compensatory cardiovascular, respiratory and behavioral (thirst and sodium appetite) adjustments to dehydration and underlying arterial hypertension. The study will focus on a model circuit involving a triangle formed by nucleus of the solitary tract (NTS), rostro-ventrolatera…
(Only some records are available in English at this moment)
This work plan deals with obtaining and characterizing ruthenium II semi-sandwich complexes containing ligands of biological interest, as new candidates for metallopharmaceuticals, being an integral part of the thematic project "X-Ray Diffraction as a Tool in the Development of Potential Drugs" (2017/15850-0). In the synthesis stage, it is intended to carry out a "screening" to evaluate t…
Cancer is one of the most deadly diseases in the world, in addition to being always growing, both in number and in diversity. Thus, in view of the need for more efficient drugs than those found on the market, and with fewer side effects than those presented by the drugs used in the treatment of the disease, the development of organic or inorganic anticancer agents, in order to find new dr…
The development of metallic compounds to find new drug candidates for the treatment of cancer has gained increasing importance in the scientific field, considering that cancer is a serious public health problem worldwide. Therefore, several metallic compounds have been studied, seeking to identify more selective and effective compounds. In particular, ruthenium-based compounds have shown …
(Only some records are available in English at this moment)
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