The purpose of the Young Investigator Grant (JP) is to support a scientifically sound and high-quality research project. It also aims to encourage the attraction, under internationally competitive conditions, of young researchers with demonstrated international postdoctoral research experience who are still in the process of establishing their professional careers, to research institutions in the State of São Paulo.
The purpose of the Young Investigator Grant Phase 2 (JP-2) is to enable the consolidation of research lines initiated by applicants who have previously received a highly successful Young Investigator Grant (JP) from FAPESP.
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Dementia is among the leading causes of global morbidity and mortality and Alzheimer's disease (AD) is responsible for 60-70% of all dementia diagnoses. Cerebrovascular alterations occur in patients with Alzheimer's disease, significantly contributing to disease development and progression. Endothelin-1 (ET-1) is an endogenously peptide, secreted mainly by endothelial cells but also by ne…
Prostate cancer (PCa) represents a growing public health challenge, with projected increases in both incidence and mortality rates. Despite significant advances in molecular biology, the complexity of PCa continues to hinder the development of effective therapies. Immunotherapy, while promising, shows limited efficacy in PCa, partly due to the low infiltration and activation of immune cel…
Synaptic disconnections have been mostly associated with neurodegenerative diseases, pathological aging and stress exposure. Thus, since the brain was found plastic, scientists have been trying to boost synaptic connectivity. Unfortunately, the concept of increased connections has been indiscriminately conflated with the concept of increased neuronal plasticity. However, especially under …
(Only some records are available in English at this moment)
Understanding how light induces chemical transformations at the molecular level is key to developing photochemical reactions that underlie the design of novel compounds and materials. In this Young Investigator project, we propose to investigate molecular reactivity concepts that enable the structural, magnetic, and mechanistic understanding of light-driven processes. Aim 1 explores the c…
The main objective of this project is to investigate the formation and evolution of accreting white dwarfs using numerical simulations. The study of accreting white dwarfs bears relevance for several fields of research due to their wide variety of phenomena, over virtually all wavelengths and on a broad range of timescales, which makes them natural laboratories to investigate, for instanc…
Nitrate contamination is almost ubiquitous in urban unconfined aquifers, becoming a challenge for the São Paulo State where more than 80% of its municipalities are supplied totally or partially by groundwater. Despite the several existing studies, there are critical scientific challenges that overcoming will contribute to the environmental management of extensive contaminated urban areas.…
(Only some records are available in English at this moment)
Soluções baseadas na natureza, particularmente Infraestrutura Verde-Azul (IVA), estão ganhando força como estratégias eficazes para mitigar riscos relacionados ao clima em ambientes urbanos. Cidades como São Paulo no Brasil e Roterdam na Holanda enfrentam riscos crescentes de calor extremo, secas, inundações e doenças transmitidas por mosquitos, impulsionados pela rápida urbanização e mud…
As interações entre espécies são engrenagens centrais da estrutura, dinâmica e funcionamento dos ecossistemas. Atualmente, conceitos e métodos oriundos da ciência das redes complexas são amplamente utilizados no estudo de redes bipartidas que descrevem uma forma de interação ecológica (e.g., planta-herbívoro). Este projeto propõe inovações no estudo das interações entre espécies com aplic…
As emissões resultantes da queima de biomassa desempenham um papel crítico no balanço global de carbono, afetando o clima, a qualidade do ar e a saúde humana. Na América do Sul, estimativas precisas e acessíveis das emissões são essenciais para o monitoramento de longo prazo. Este projeto visa desenvolver o South American Biomass Burning Inventory (SAMBBI), inventário contínuo e de acesso…
(Only some records are available in English at this moment)
Entender como a luz induz transformações químicas a nível molecular é fundamental para o desenvolvimento de reações fotoquímicas que sustentam o planejamento de novos compostos e materiais. Neste projeto de Jovem Pesquisador propomos investigar conceitos de reatividade molecular que possibilitem uma compreensão estrutural, magnética e mecanística de processos impulsionados pela luz. No su…
As doenças inflamatórias intestinais (DIIs) constituem um grupo de doenças inflamatórias crônicas que afeta o trato gastrointestinal (GI), que inclui a doença de Crohn (DC) e a retocolite ulcerativa (RCU). Apesar da sua etiologia ser desconhecida, desequilíbrios da resposta imune do hospedeiro à microbiota intestinal associados à fatores genéticos e ambientais contribuem para a patogênese…
O principal objetivo deste projeto é investigar a formação e evolução de anãs brancas acretantes com simulações numéricas. O estudo das anãs brancas acretantes é relevante para diversos campos de pesquisa devido à sua grande variedade de fenômenos, em praticamente todos os comprimentos de onda e em uma ampla gama de tempos de escala, o que as torna laboratórios naturais para investigar, p…
(Only some records are available in English at this moment)
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