The memorandum of understanding with UK Research and Innovation (UKRI) includes the Medical Research Council (MRC), that encourages and supports research to improve human health.
Over 1 billion people are at risk of infection with the vector-borne parasitic protozoan, Leishmania. In South and Central America, Leishmania species in the sub-genus Viannia, such as L. braziliensis, cause cutaneous and mucocutaneous leishmaniasis. Unlike many other Neglected Tropical Diseases that have seen great recent success in reduction measures, including malaria and Sleeping Sic…
Neural tube defects (NTDs) are severe congenital anomalies that impact the central nervous system (CNS), posing significant public health challenges, especially in Brazil. These defects originate from malformations during the early stages of neural tube (NT) development. Despite advancements in understanding neural stem cell behavior and neurogenesis, substantial knowledge gaps persist du…
The burden and disability associated with chronic respiratory diseases (CRDs) are considerable, particularly in the most disadvantaged societies such as Low and Middle-Income Countries. Prospectively, the chronic obstructive pulmonary disease (COPD) will continue to increase worldwide. With a population exceeding 210 million, COPD in Brazil constitutes a health challenge with the prevalen…
(Only some records are available in English at this moment)
In this collaborative project with the University of Glasgow, we propose, for the first time, an analysis of an overlooked but critical and still neglected aspect of the cycle of the parasite Plasmodium vivax (Pv), referring to the infection of this pathogen in the potential niches hematopoietic. Here, we will systematically investigate Pv infection in one of the main hematopoietic niches…
Emerging and re-emerging diseases are a major public health problem. In the past years, the world has been threatened by several important emerging or re-emerging infectious diseases, such as Ebola, Avian Influenza A, Yellow Fever (YFV), Dengue (DENV), West Nile Fever (WNV) among others. In Brazil, the emerging infections caused by arboviruses such as DENV and YIF are historical and have …
Leishmaniasis is a devastating parasitic disease that targets the poorest of society and is the 9th largest global infectious disease burden (WHO). It is truly a Neglected Infectious Disease as the combined financial support of basic and clinical research equates to <2% of infectious disease R&D resources available. Consequently, there are no vaccines available currently and the limited a…
(Only some records are available in English at this moment)
The Covid-19 pandemic has raised concerns regarding the use and development of screening and diagnostic models that are low-cost, highly sensitive, and widely applicable. The widespread dissemination of this virus makes it difficult to control, making mass testing of individuals an efficient measure for screening and controlling its spread. However, the high cost of tests, coupled with th…
The availability of viral genome sequencing techniques and projections by means of mathematical, statistical, and computational models allow tracking the emergence and spread of infectious diseases on a local and global scale. Since the first confirmed case of SARS-CoV-2 infection, these techniques and analyses are responsible for an active and continuous monitoring of the epidemiological…
(Only some records are available in English at this moment)
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