Biotechnology and Biological Sciences Research Council (BBSRC) - FAPPA

The memorandum of understanding with UK Research and Innovation (UKRI) includes the Biotechnology and Biological Sciences Research Council (BBSRC) as well as the modality Pump-Priming Award (FAPPA). The aim of this award is to provide short term pump-priming to new collaborations between FAPESP-funded research groups in the State of São Paulo, Brazil, and BBSRC-funded research groups in the UK.

Biotechnology and Biological Sciences Research Council (BBSRC)

BBSRC, UKRI - FAPPA

Research grants

Completed (most recent)

Abstract
In the present project, we wish to lest the hypothesis that SCFA regulate innate immunity of intestinal epithelial cells (enterocytes and related cells) by affecting histone modifications, especially modifications that may metabolically directly relate to SCFA, such as lysine acetylation and crotonylation. To test our ideas we will employ intestinal organoid culture ("mini-guts"), mouse m…
Role of epigenetic changes induced by SCFAs in intestinal epithelial cells, AP.R
Abstract
This project would use novel developments for spectroscopic characterization of these AMP in liposomes, lipid films and lipid monolayers to establish the mechanism of action and optimize the design of novel related peptides as bacteriocins. The project will also focus on the identification and characterisation of new hyper-stable enzymes isolated from petrochemical sources. Extremophiles …
Biophysical studies of the structure/function of antimicrobial peptides and enzymes isolated from extremophile organisms, AP.R
Abstract
Trafficking of glutamatergic AMPA receptors (AMPAR) plays a crucial role in modulating synaptic transmission in the hippocampus. AMPAR density at postsynaptic sites is thought to be determined by a combination of constitutive and signal-regulated protein trafficking pathways that comprise of polarized sorting from the trans golgi network (TGN) to somatodendritic membranes, endocytosis, en…
Role of endosomal sorting machinery controlling AMPA receptors trafficking in the hippocampus, AP.R