New quiral metal catalysts and their applications in asymmetric catalysis

• Grant number: 18/01669-5
• Support Opportunities: Research Grants - Young Investigators Grants
• Start date: May 01, 2018
• End date: October 31, 2023
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Caio Costa Oliveira
• Grantee: Caio Costa Oliveira
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• City of the host institution: Campinas
• Associated scholarship(s): 23/10646-7 - Synthesis of enantioenriched helical complexes, BP.DD; 23/11021-0 - Remote functionalization by terminal olefin monotransposition, catalyzed by nickel under kinetic control, BP.DD; 20/12435-5 - Synthesis of new enantioenriched half-sandwich ligands and its applications to enantioselective ruthenium-catalyzed C-H functionalization reactions, BP.DD; + associated scholarships 19/15883-1 - Synthesis and catalytic activity of enantioenriched complexes bearing bisfunctional ligands, BP.DD; 19/00080-0 - Synthesis and catalytic activity of metal complexes bearing enantioenriched sulphoxides ligands, BP.DD; 18/18490-8 - New chiral ruthenium complexes and their applications in asymmetric catalysis, BP.MS - associated scholarships

Abstract

Catalytic methods for the synthesis of enantiomerically pure compounds are of great importance for the preparation of pharmacologically active substances and for Fine Chemicals. The rational development of enantioenriched ligands allows the preferential preparation of one of the two enantiomeric products in reactions catalyzedby transition metals. The main topic of this research project is the development of new classes of enantioenriched ligands and their use on the synthesis of new chiral metal complexes. More specifically, it will cover two research lines: 1) the design of chiral half-sandwich complexes and its application for asymmetric transformations; 2) the synthesis of new ligands able to coordinate simultaneously to two metals (or a metal and a Lewis acid) and use them to create novel process involving, at least, a sequence of two distinct reactions. The success of this project will allow the development of a new research field in asymmetric catalysis. (AU)

Scientific publications

(10)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

OLIVEIRA, CAIO C.; DUARTE CORREIA, CARLOS ROQUE. Enantioselective Heck-Matsuda Reactions: From Curiosity to a Game-Changing Methodology. CHEMICAL RECORD, JUN 2021. (13/07600-3, 14/25770-6, 18/01669-5)

DE SOUZA, EDSON LEONARDO SCARPA; OLIVEIRA, CAIO C.. Selective Radical Transformations with Aryldiazonium Salts. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, v. 26, n. 12, p. 23-pg., 2023-02-28. (18/01669-5, 14/25770-6, 19/25657-9)

SCALON, LUCAS; SZOSTAK, RODRIGO; ARAUJO, FRANCINEIDE L.; ADRIANI, KARLA F.; SILVEIRA, JULIAN F. R., V; OLIVEIRA, WILLIAN X. C.; DA SILVA, JUAREZ L. F.; OLIVEIRA, CAIO C.; NOGUEIRA, ANA FLAVIA. Improving the Stability and Efficiency of Perovskite Solar Cells by a Bidentate Anilinium Salt. JACS AU, v. 2, n. 6, p. 7-pg., 2022-06-27. (18/01669-5, 17/11631-2, 20/04406-5, 20/14451-8, 17/12582-5, 19/08257-7, 18/21401-7, 18/11152-0, 14/25770-6)

SCALON, LUCAS; NOGUEIRA, CHARLES ALVES; FONSECA, ANDRE FELIPE VALE; MARCHEZI, PAULO E.; MORAL, RAPHAEL FERNANDO; GRANCINI, GIULIA; KODALLE, TIM; SUTTER-FELLA, CAROLIN M.; OLIVEIRA, CAIO COSTA; ZAGONEL, LUIZ F.; et al. 2D Phase Formation on 3D Perovskite: Insights from Molecular Stiffness. ACS APPLIED MATERIALS & INTERFACES, v. 16, n. 38, p. 11-pg., 2024-09-13. (21/06893-3, 20/04406-5, 23/10395-4, 18/01669-5, 22/06645-2, 17/11986-5)

SOUSA, LEONARDO DA SILVA; STRAPASSON, GUILHERME BOENNY; BUENO, JOSE MARIA CORREA; OLIVEIRA, CAIO COSTA; ZANCHET, DANIELA. Pt Molecularly Defined Precursors to Tune Particle Size and Speciation: Impact on the Reverse Water Gas Shift Reaction. CHEMISTRY OF MATERIALS, v. 36, n. 9, p. 13-pg., 2024-04-18. (18/01258-5, 18/01669-5, 20/12986-1, 20/08575-6)

BRANDAO-TELES, CAROLINE; CARREGARI, VICTOR CORASOLLA; REIS-DE-OLIVEIRA, GUILHERME; SMITH, BRADLEY J.; CHAVES, YANE; SOUSA SANTOS, ALINE VALERIA; PINHEIRO, ERICK MARTINS DE CARVALHO; OLIVEIRA, CAIO C.; VIEIRA, ANDRE SCHWAMBACH; CRUNFLI, FERNANDA; et al. Impacts of hnRNP A1 Splicing Inhibition on the Brain Remyelination Proteome. Journal of Neurochemistry, v. 169, n. 1, p. 16-pg., 2025-01-01. (19/22398-2, 17/25588-1, 18/01669-5, 23/08885-3, 18/01410-1, 19/05155-9, 23/11514-7)

PINHEIRO, ERICK M. C.; COUTO, DANIEL P.; OLIVEIRA, CAIO C.. Ru(II)-catalyzed ortho C-H Arylation of Heterocyclic Biaryls. ASIAN JOURNAL OF ORGANIC CHEMISTRY, v. N/A, p. 5-pg., 2024-11-23. (20/12435-5, 23/11514-7, 18/01669-5)

OLIVEIRA, CAIO C.; DUARTE CORREIA, CARLOS ROQUE. Enantioselective Heck-Matsuda Reactions: From Curiosity to a Game-Changing Methodology. CHEMICAL RECORD, v. 21, n. 10, SI, p. 2688-2701, OCT 2021. (18/01669-5, 13/07600-3, 14/25770-6)

OLIVEIRA, CAIO C.; CORREIA, CARLOS ROQUE D.. The palladium-catalyzed Heck arylation of olefins with arenediazonium salts as a sustainable strategy in organic synthesis. CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY, v. 26, DEC 2020. (14/25770-6, 13/07600-3, 18/01669-5)

SCALON, LUCAS; VAYNZOF, YANA; NOGUEIRA, ANA FLAVIA; OLIVEIRA, CAIO C.. How organic chemistry can affect perovskite photovoltaics. CELL REPORTS PHYSICAL SCIENCE, v. 4, n. 5, p. 21-pg., 2023-05-17. (17/11631-2, 21/12104-1, 18/01669-5, 18/21401-7, 20/04406-5, 14/25770-6)