Identification of secondary metabolites in Harpagophytum procumbens extracts that inhibit cyclooxygenases 1/2 and 5 - lipoxygenase expression and/or activities

• Grant number: 17/50293-5
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2018
• End date: April 30, 2019
• Field of knowledge: Health Sciences - Pharmacy - Pharmacognosy
• Agreement: University of Missouri
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: Fernando Batista da Costa
• Grantee: Fernando Batista da Costa
• Principal researcher abroad: William Folk
• Institution abroad: University of Missouri, Columbia (UM), United States
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The proposed project explores a botanical, Harpagophytum procumbens subsp. procumbens (Burch.) DC. Ex Meisn, family Pedaliaceae (Devil's Claw; Garra do Diabo) for which there is evidence of benefit to human health, namely its use in management of inflammatory arthritis, lower back pain and other musculoskeletal conditions. H. procumbens is one of the most frequently used herbal products for these conditions in Europe, and also is widely used in Africa, the United States and Brazil (and other countries). Recent studies support its potential utility, however the variability in the products being marketed and lack of well-defined mechanisms and biological targets impede medical acceptance. (AU)