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Synthesis and application of ionic liquids to unveil the chemistry of fermentative processes

Grant number: 17/25490-1
Support type:Regular Research Grants
Duration: June 01, 2018 - May 31, 2020
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Principal Investigator:Leandro Wang Hantao
Grantee:Leandro Wang Hantao
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Assoc. researchers:Fernanda Furlan Gonçalves Dias ; Ronei Jesus Poppi


In this research project, we propose the development of a technological solution to investigate the chemistry of fermented beverages by combining ionic liquids (IL), comprehensive two-dimensional gas chromatography (GCxGC), and chemometrics ('artificial inteligence'). Beverage analysis is a demanding task due to the overwhelming quantity of analytes with highly diverse chemical and physical properties that limits the application of traditional protocols. Analytical Chemistry has benefited from the incredible advances in technology of the past decades. Today, the development of highly efficient sorbent phases, capable of extracting a broad diversity of molecules, and the outcome of high-resolution instruments, which produces dense and intrinsically multivariate data, which challenges even the most veteran GC practitioner. Application of ionic liquids in microextractions of organic compounds are now highly effective, due to the unique solvation properties of IL. Also, GCxGC coupled to mass spectrometry (GCxGC-MS) has enabled improved peak capacity separations of many matrices, producing high quality measurements. Furthermore, artificial intelligence-based approaches using chemometric techniques are desperately required to manage and explore such big data. This orthogonal approach is likely the most efficient path for data mining to unveil the complex chemistry of fermentative processes and related applications. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PAIVA, ANDRE CUNHA; OLIVEIRA, DANIEL SIMOES; HANTAO, LEANDRO WANG. A Bottom-Up Approach for Data Mining in Bioaromatization of Beers Using Flow-Modulated Comprehensive Two-Dimensional Gas Chromatography/Mass Spectrometry. SEPARATIONS, v. 6, n. 4 DEC 2019. Web of Science Citations: 0.
PASSINI, RODRIGO; PIERONE, DANILO; GOBBI, ANGELO L.; HANTAO, LEANDRO W. Flow Modulated Comprehensive Two-Dimensional Gas Chromatography Part I - Low Duty Cycle Modulation of Hidroprocessed Vegetable Oil. BRAZILIAN JOURNAL OF ANALYTICAL CHEMISTRY, v. 6, n. 24, p. 74-81, JUL-SEP 2019. Web of Science Citations: 0.
BELINATO DE SOUZA, JOAO R.; DIAS, FERNANDA F. G.; CALIMAN, JAQUELINE D.; AUGUSTO, FABIO; HANTAO, LEANDRO W. Opportunities for green microextractions in comprehensive two-dimensional gas chromatography / mass spectrometry-based metabolomics - A review. Analytica Chimica Acta, v. 1040, p. 1-18, DEC 21 2018. Web of Science Citations: 5.

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