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Therapeutic vaccine based on aDC1 dendritic cells pulsed with inactivated autologous virus for the control of viremia after ATI in HIV infected individuals

Abstract

Dendritic cell based immunotherapy is a potential tool to stimulate a specific immune response, as a complementary treatment for HIV-infected individuals using ART. Polarizing DCs are capable to produce high levels of IL-12p70 and induce a strong cytotoxic response that is very useful in viral infections. In this context, we propose to study aDC1 pulsed with autologous inactivated virus for treatment of HIV infected individuals. The study will include 30 diagnosed HIV-infected patients not ART treated at inclusion time. Six months after treatment initiation they will be immunized or not with aDC1 according to the arms of this study: G1) placebo control/without ART interruption; G2) aDC1immunization/without ART interruption; G3) aDC1 immunization/analytical treatment interruption. Autologous PBMCs will be collected for virus isolation and patients will start ART. Waiting for 24 weeks for PVL going below detection, samples will be collected for baseline parameters and vaccine will be inoculated in 3 doses (with a fortnight interval). Three weeks after 3th vaccine inoculation, ART will be interrupted only for G3 patients. Patients will be followed for more 12 weeks and blood and biopsis (jejunum) samples will be collected for different parameters measurement as immune activation, immunogenecity, humoral response, mucosal cellular immunity and virologic profile and viral reservoir analysis. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LUANDA MARA DA SILVA OLIVEIRA; BRUNA TIAKI TIYO; LAIS TEODORO DA SILVA; LUIZ AUGUSTO MARCONDES FONSECA; ROSANA COURA ROCHA; VERA APARECIDA DOS SANTOS; CARINA CENEVIVA; ANDERSON APARECIDO BEDIN; ALEXANDRE DE ALMEIDA; ALBERTO JOSÉ DA SILVA DUARTE; TELMA MIYUKI OSHIRO. Prevalence of anti-SARS-CoV-2 antibodies in outpatients of a large public university hospital in Sao Paulo, Brazil. Revista do Instituto de Medicina Tropical de São Paulo, v. 62, p. -, 2020. Web of Science Citations: 0.
DA SILVA, LAIS TEODORO; SANTILLO, BRUNA TERESO; DE ALMEIDA, ALEXANDRE; DA SILVA DUARTE, ALBERTO JOSE; OSHIRO, TELMA MIYUKI. Using Dendritic Cell-Based Immunotherapy to Treat HIV: How Can This Strategy be Improved?. FRONTIERS IN IMMUNOLOGY, v. 9, DEC 18 2018. Web of Science Citations: 5.

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