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Mitochondrial dicarboxylate carriers and mitochondrial uncoupling proteins (UCP) as targets for improving plant tolerance to abiotic stress


Mitochondrial transporters are involved in the exchange of metabolites and intermediates between mitochondria and cellular cytoplasm. Due to their known participation in the maintenance of mitochondrial homeostasis and in plant response to environmental stresses, these transporters have attracted interest of plant biologists. The present project will focus on dicarboxylate transporters (DICs), whose function is still little studied, and uncoupling mitochondrial proteins (UCPs), known to be important modulators of the redox state. Our working hypothesis is that a better understanding of the in planta functions of these transporters will assist future approaches that aim to manipulate these genes for the acquisition of tolerance to abiotic stresses. Different approaches will be used to investigate the role and relevance of these transporters on mitochondrial metabolism and stress tolerance mechanisms of Arabidopsis thaliana. It is expected that the generated data will provide subsidies to better understand the respective in planta functions of the said proteins and demonstrate the physiological relevance of each of them in the acquisition of stress tolerance. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CAMPOS ARCURI, MARIANA DE LARA; NUNES-LAITZ, ALESSANDRA VASCONCELLOS; MACEDO LIMA, ROMULO PEDRO; BARRETO, PEDRO; MARINHO, ANDRESSA NAGATANI; ARRUDA, PAULO; MAIA, IVAN G.. Knockdown of Mitochondrial Uncoupling Proteins 1 and 2 (AtUCP1 and 2) in Arabidopsis thaliana Impacts Vegetative Development and Fertility. Plant and Cell Physiology, v. 62, n. 10, p. 1630-1644, . (17/25139-2, 18/19021-1)
LIMA, ROMULO PEDRO MACEDO; NUNES-LAITZ, ALESSANDRA VASCONCELLOS; ARCURI, MARIANA DE LARA CAMPOS; CAMPOS, FELIPE GIROTTO; JOCA, THAIS ARRUDA COSTA; MONTEIRO, GEAN CHARLES; KUSHIMA, HELIO; LIMA, GIUSEPPINA PACE PEREIRA; ALMEIDA, LUIZ FERNANDO ROLIM DE; BARRETO, PEDRO; et al. The double knockdown of the mitochondrial uncoupling protein isoforms reveals partial redundant roles during Arabidopsis thaliana vegetative and reproductive development. Plant Science, v. 322, p. 13-pg., . (18/19021-1, 17/25139-2)

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