Research Grants 17/26400-6 - Microbiota, Gastroplastia - BV FAPESP
Advanced search
Start date
Betweenand

Impact of gastroplasty on salivary composition and cytomorphology of oral mucosa: follow-up three and six months

Abstract

The aim of this study is to evaluate the impact of gastroplasty in salivary physicochemical and microbiological composition, concentration of sulfurated compounds volatile related to halitosis and cytomorphology of the oral mucosa of 60 obese adults (18-40 years of age) undergoing gastroplasty (Capella technique) evaluated before and 3 and 6 months after surgery. Thirty normal weight (body mass index between 18.5 and 24.9 kg/m2), matched for sex and age, will be part of the control group, which will also be evaluated three times. The physical examination includes measurements of height, weight, fat mass and skeletal muscle mass through a digital stadiometer and bioelectrical impedance analysis. DMFT and Community Periodontal Index will verify the oral health status. The self- perception of oral health- related quality of life will be verify using OHIP-14 questionnaire. Salivary amylase, total protein, calcium, urea, uric acid, phosphorus, 25-hidroxivitamin D2 and 25 hidroxivitamin D3 concentrations will be determined in stimulated and unstimulated saliva by automated technique (colorimetry or HPLC). ELISA assays will analyze salivary cytokines. Salivary DNA samples will be purified and subjected to quantitative PCR reactions (qPCR) in order to determine the proportion of Selenomonas noxia, Bifidobacteria, Streptococcus mutans and Prevotella intermedia in relation to the total bacterial load. Micronucleus test will analyze oral mucosa cells. The description of the study variables and their correlation will be analyzed using descriptive statistics, normality test and correlation tests (Pearson or Spearman). Principal component analysis will verify the salivary characteristics of the patients at baseline and Two-way ANOVA and Tukey pot-test will be used for comparisons between groups. Two-way ANOVA repeated measures will verify the changes resulting from bariatric surgery (± = 0.05). (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
More itemsLess items
Articles published in other media outlets ( ):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (18)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ANDRADE, ERIC FRANCELINO; PEREIRA, LUCIANO JOSE; LUIZ DE OLIVEIRA, ANA PAULA; ORLANDO, DEBORA RIBEIRO; GALDINO ALVES, DEBORA ALMEIDA; GUILARDUCCI, JANINA DE SALES; CASTELO, PAULA MIDORI. erceived fear of COVID-19 infection according to sex, age and occupational risk using the Brazilian version of the Fear of COVID-19 Scal. DEATH STUDIES, v. 46, n. 3, . (17/26400-6)
PEREIRA CARDOSO, JULIANO PAULO; RAMOS AFONSO, MARCOS VINICIUS; MENDES, BRUNO FERREIRA; VIEIRA, ETEL ROCHA; PEREIRA, WAGNER DE FATIMA; DIAS-PEIXOTO, MARCO FABRICIO; CASTELO, PAULA MIDORI; PEREIRA, LUCIANO JOSE; ANDRADE, ERIC FRANCELINO. Fear of COVID-19 influences physical activity practice: a study in a Brazilian sample. PSYCHOLOGY HEALTH & MEDICINE, v. N/A, p. 9-pg., . (17/26400-6)
ROSAR, JOAO VICENTE; SALOME MARQUEZIN, MARIA CAROLINA; PIZZOLATO, AIANNE SOUTO; KOBAYASHI, FERNANDA YUKIE; BUSSADORI, SANDRA KALIL; PEREIRA, LUCIANO JOSE; CASTELO, PAULA MIDORI. Identifying predictive factors for sleep bruxism severity using clinical and polysomnographic parameters: a principal component analysis. JOURNAL OF CLINICAL SLEEP MEDICINE, v. 17, n. 5, p. 949-956, . (17/26400-6, 16/10940-9)
LOURO, TERESA; SIMOES, CARLA; PENETRA, MARIA JOAO; CARREIRA, LAURA; CASTELO, PAULA MIDORI; LUIS, HENRIQUE; MOREIRA, PEDRO; LAMY, ELSA. Relationship between Mediterranean Diet Adherence and Saliva Composition. NUTRIENTS, v. 13, n. 4, . (17/26400-6)
MARQUEZIN, MARIA CAROLINA SALOME; CHAVES-JUNIOR, SAMUEL DE CARVALHO; RASERA, JR., IRINEU; PACHECO, ELISANE ROSSIN PESSOTTI; GAVIAO, MARIA BEATRIZ DUARTE; LAMY, ELSA; CASTELO, PAULA MIDORI. Oral Health and Nutritional Characteristics of Adults With Morbid Obesity: A Multivariate Analysis. FRONTIERS IN NUTRITION, v. 7, . (17/26400-6, 16/10940-9)
FINASSI, CAROLINA MARTINS; CALIXTO, LEANDRO A.; SEGURA, WILSON; BOCATO, MARIANA ZUCCHERATO; BARBOSA JR, FERNANDO; FONSECA, FERNANDO L. A.; LAMY, ELSA; CASTELO, PAULA MIDORI. Effect of sweetened beverages intake on salivary aspartame, insulin and alpha-amylase levels: A single-blind study. Food Research International, v. 173, p. 8-pg., . (19/04666-0, 17/26400-6)
AZZI, DIANA VILELA; MELO, JULIA; CAMPOS NETO, ARMINDO DE ARRUDA; CASTELO, PAULA MIDORI; ANDRADE, ERIC FRANCELINO; PEREIRA, LUCIANO JOSE. Quality of life, physical activity and burnout syndrome during online learning period in Brazilian university students during the COVID-19 pandemic: a cluster analysis. PSYCHOLOGY HEALTH & MEDICINE, v. 27, n. 2, p. 15-pg., . (17/26400-6)
FERREIRA, CLAUDIA LUCIA PIMENTA; CASTELO, PAULA MIDORI; ZANATO, LUCIANA ESCANOELA; POYARES, DALVA; TUFIK, SERGIO; BOMMARITO, SILVANA. Relation between oro-facial thermographic findings and myofunctional characteristics in patients with obstructive sleep apnoea. Journal of Oral Rehabilitation, v. 48, n. 6, p. 10-pg., . (17/26400-6)
RIBEIRO, AIANNE SOUTO PIZZOLATO; MARQUEZIN, MARIA CAROLINA SALOME; PACHECO, ELISANE ROSSIN PESSOTTI; RASERA JR, IRINEU; KLEIN, MARLISE INES; DE VASCONCELLOS, SUZAN PANTAROTO; LANDGRAF, RICHARDT GAMA; OKAMOTO, DEBORA; CALIXTO, LEANDRO AUGUSTO; CASTELO, PAULA MIDORI. Bypass gastroplasty impacts oral health, salivary inflammatory biomarkers, and microbiota: a controlled study. CLINICAL ORAL INVESTIGATIONS, v. 27, n. 8, p. 12-pg., . (20/16020-4, 16/10940-9, 17/26400-6)
ANDRADE, ERIC FRANCELINO; PEREIRA, LUCIANO JOSE; ORLANDO, DEBORA RIBEIRO; DIAS PEIXOTO, MARCO FABRICIO; LEE, SHERMAN A.; CASTELO, PAULA MIDORI. Validation of the Brazilian Portuguese version of the Obsession with COVID-19 Scale (BP-OCS) using a large University Sample in Brazil. DEATH STUDIES, . (17/26400-6)
FERREIRA, CLAUDIA LUCIA PIMENTA; CASTELO, PAULA MIDORI; ZANATO, LUCIANA ESCANOELA; POYARES, DALVA; TUFIK, SERGIO; BOMMARITO, SILVANA. Relation between oro-facial thermographic findings and myofunctional characteristics in patients with obstructive sleep apnoea. Journal of Oral Rehabilitation, . (17/26400-6)
AZZI, DIANA VILELA; MELO, JULIA; CAMPOS NETO, ARMINDO DE ARRUDA; CASTELO, PAULA MIDORI; ANDRADE, ERIC FRANCELINO; PEREIRA, LUCIANO JOSE. uality of life, physical activity and burnout syndrome during online learning period in Brazilian university students during the COVID-19 pandemic: a cluster analysi. PSYCHOLOGY HEALTH & MEDICINE, v. 27, n. 2, . (17/26400-6)
SALOME MARQUEZIN, MARIA CAROLINA; DE OLIVEIRA SCUDINE, KELLY GUEDES; LAMY, ELSA; FINASSI, CAROLINA MARTINS; CARREIRA, LAURA; SEGURA, WILSON DIAS; RASERA JR, IRINEU; PESSOTTI, ELISANE ROSSIN; CASTELO, PAULA MIDORI. Impact of gastroplasty on salivary characteristics, dental health status and oral sensory aspects: A controlled clinical study. Journal of Oral Rehabilitation, v. 49, n. 10, p. 10-pg., . (16/10940-9, 17/26400-6, 19/04666-0)
ARAUJO, DARLLE SANTOS; DE OLIVEIRA SCUDINE, KELLY GUEDES; PEDRONI-PEREIRA, ALINE; DUARTE GAVIAO, MARIA BEATRIZ; PEREIRA, EDIMAR CRISTIANO; AFFONSO FONSECA, FERNANDO LUIZ; CASTELO, PAULA MIDORI. Salivary uric acid is a predictive marker of body fat percentage in adolescents. Nutrition Research, v. 74, p. 62-70, . (14/24804-4, 17/26400-6)
ANDRADE, ERIC FRANCELINO; PEREIRA, LUCIANO JOSE; LUIZ DE OLIVEIRA, ANA PAULA; ORLANDO, DEBORA RIBEIRO; GALDINO ALVES, DEBORA ALMEIDA; GUILARDUCCI, JANINA DE SALES; CASTELO, PAULA MIDORI. Perceived fear of COVID-19 infection according to sex, age and occupational risk using the Brazilian version of the Fear of COVID-19 Scale. DEATH STUDIES, v. 46, n. 3, p. 10-pg., . (17/26400-6)
ARAUJO, DARLLE SANTOS; KLEIN, MARLISE INEZ; SCUDINE, KELLY GUEDES DE OLIVEIRA; DE SALES LEITE, LUANA; PARISOTTO, THAIS M.; FERREIRA, CAROLINE MARCANTONIO; FONSECA, FERNANDO LUIZ AFFONSO; PEREZ, MATHEUS MOREIRA; CASTELO, PAULA MIDORI. Salivary Microbiological and Gingival Health Status Evaluation of Adolescents With Overweight and Obesity: A Cluster Analysis. FRONTIERS IN PEDIATRICS, v. 8, . (14/24804-4, 17/26400-6)
LOURO, TERESA; SIMOES, CARLA; LIMA, WILMARA; CARREIRA, LAURA; CASTELO, PAULA MIDORI; LUIS, HENRIQUE; MOREIRA, PEDRO; LAMY, ELSA. Salivary Protein Profile and Food Intake: A Dietary Pattern Analysis. JOURNAL OF NUTRITION AND METABOLISM, v. 2021, p. 10-pg., . (17/26400-6)
ANDRADE, ERIC FRANCELINO; PEREIRA, LUCIANO JOSE; ORLANDO, DEBORA RIBEIRO; DIAS PEIXOTO, MARCO FABRICIO; LEE, SHERMAN A.; CASTELO, PAULA MIDORI. Validation of the Brazilian Portuguese version of the Obsession with COVID-19 Scale (BP-OCS) using a large University Sample in Brazil. DEATH STUDIES, v. 46, n. 5, p. 7-pg., . (17/26400-6)