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Sepsis: mechanisms, therapeutic targets and epidemiology

Grant number: 17/21052-0
Support type:Research Projects - Thematic Grants
Duration: July 01, 2018 - June 30, 2023
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Reinaldo Salomão
Grantee:Reinaldo Salomão
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo, SP, Brazil
Co-Principal Investigators:Flavia Ribeiro Machado ; Ivan Hong Jun Koh ; Luciano Cesar Pontes de Azevedo
Assoc. researchers:Alexandre Keiji Tashima ; Ana Maria Alvim Liberatore ; Francisco Garcia Soriano ; Milena Karina Coló Brunialti
Associated scholarship(s):18/19855-0 - Evaluation of cellular metabolism in endotoxin tolerant peripheral blood mononuclear cells, BP.IC


In Brazil, about one-third of the intensive care beds are occupied by septic patients, with a mortality rate of 55.7% compared to the 26% worldwide averages reported recently. In this project we intend to integrate basic and clinical research in Sepsis, ranging from the pathogenesis and development of intervention strategies to epidemiological studies that allow us to know the reality of sepsis in our country. The project covers three lines of research: experimental, translational and epidemiological research. These lines are structured in three integrated axes of action: 1- translational research: we settled a network of hospitals, which will prospectively monitor patients with Sepsis, with storage of clinical and epidemiological information. Biological samples of the patients will be processed in the immunology laboratory, where studies of gene expression, protein and cellular function will be conducted with a focus on immunometabolism; a possible therapeutic target should be tested in an intervention - proof of concept; 2 - experimental research: models of animal experimentation and computational modeling where new hypotheses and potential therapeutic targets will be evaluated; 3- epidemiological studies will be conducted in association with a network of researchers from emergency and intensive care units to characterize demographic data on Sepsis in Brazil. (AU)