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Integrating chromosome and genomic analyses for functional and evolutionary studies of satellite DNAs in Astyanax (Teleostei, Characiformes)

Grant number: 18/03365-3
Support type:Regular Research Grants
Duration: June 01, 2018 - May 31, 2020
Field of knowledge:Biological Sciences - Genetics
Principal Investigator:Fábio Porto-Foresti
Grantee:Fábio Porto-Foresti
Home Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil
Assoc. researchers:Duílio Mazzoni Zerbinato de Andrade Silva ; Fausto Foresti ; Ricardo Utsunomia ; Sandro Natal Daniel


Eukaryotic genomas are mainly composed of repetitive DNA sequences. Among them, satellide DNAs (satDNAs) constitute unique tandemly repeated sequences. For a long time, satDNAs were considered as junk DNA; however, the transcription of this kind of sequence in distinct organisms points to different possible established functions. Historically, distinct methods were used to characterize satDNAs, but just the rise of next generation sequencing (NGS) technologies and, mainly, novel bioinformatics tools, allowed significant analyses to characterize whole catalogues of satellite DNAs (satellitome) from distinct organisms, at a relatively low cost. Recently, the first fish satellitome for Astyanax paranae was published and revealed a significant amount of satDNA families in this genome, including several ones allocated exclusively on the B chromosomes of this species. These data raised novel questions about those sequences, which are pretended to be investigated here. Thus, the objectives of this project involve get deepen on the knowledge of satellite DNAs in a. paranae using long reads; an initial functional characterization about these sequences; and a better knowledge about the satDNA libraries in distinct Characidae species and the differential expansion/retraction of satDNA families in distinct species. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CALEGARI, RODRIGO MILAN; MIRA RODRIGUES, PEDRO HENRIQUE; DOS SANTOS, RODRIGO ZENI; FORESTI, FAUSTO; UTSUNOMIA, RICARDO; PORTO-FORESTI, FABIO. The complete mitochondrial genome sequences of five Otophysi species (Vertebrata, Teleostei). MITOCHONDRIAL DNA PART B-RESOURCES, v. 4, n. 2, p. 4198-4199, JUL 3 2019. Web of Science Citations: 0.

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