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Multi-user equipment approved in grant 2017/04138-8 for high pressure semipreparative chromatographic system model LC-20AR

Grant number: 18/05080-6
Support type:Multi-user Equipment Program
Duration: May 01, 2018 - April 30, 2025
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Principal Investigator:Sergio Ricardo Ambrosio
Grantee:Sergio Ricardo Ambrosio
Home Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil
Associated research grant:17/04138-8 - Attainment of chemical, analytical, biological, pharmacological and technological studies to fill the gaps on the development of Brazilian propolis sector, AP.TEM
As informações de acesso ao Equipamento Multiusuário são de responsabilidade do Pesquisador responsável
EMU web page:
Tipo de equipamento:Caracterização de Materiais - Análises Químicas - Cromatrografia líquida
Fabricante: Shimadzu
Modelo: LC-20AR


The Brazilian propolis produced by Apis mellifera called green, brown and red have great economic importance, due to their biological activities and export to several countries, such as Japan and China, and production of approximately 200 tons per year. The main botanical origins of Brazilian propolis are: Baccharis dracunculifolia for green propolis; Araucaria sp, Eucalyptus sp and others for brown propolis; and Dalbergia ecastophyllum for the red propolis. In 2005, ANVISA published a technical note on the registration of products containing propolis, as well as the RDC no. 24/2011 authorizing the registration of propolis-based medicines. However, to date none medicine has been registered with ANVISA. There are many gaps to be filled, since ANVISA demands the execution of chemical, analytical, pharmacological and technological studies to guarantee safety, efficacy and quality in the development of new medicines. Thus, it is proposed to carry out complementary steps in phytochemical studies to obtain standardized extracts and compounds to be used in the development of analytical methods; in obtaining semi-synthetic derivatives; in stability and degradation studies; in bioaccessibility, biotransformation, pharmacokinetic and pharmacodynamic studies; in silico studies to determine chemical structure-activity relationship and docking analyses; in the development of pharmaceutical formulations; in both in vitro and in vivo toxicological studies; in studies of genotoxicity and mutagenicity; in anti-inflammatory, immunomodulatory, antimicrobial, antiparasitic, antiproliferative, healing and gastro protective assays, among others. The ultimate goal of this proposal is to add value to the Brazilian beekeeping sector. (AU)