Study of the immunogenicity of outer membrane antigens of Neisseria meningitidis and interaction with cationic lipids: evaluation of new adjuvant for Neisseria meningitidis in different strains of elderly mice

• Grant number: 18/04202-0
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2018
• End date: May 31, 2020
• Field of knowledge: Biological Sciences - Immunology - Applied Immunology
• Principal Investigator: Elizabeth Natal de Gaspari
• Grantee: Elizabeth Natal de Gaspari
• Host Institution: Instituto Adolfo Lutz (IAL). Coordenadoria de Controle de Doenças (CCD). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Study of the immunogenicity of outer membrane antigens of Neisseria meningitidis and interaction with cationic lipids: evaluation of new adjuvant for Neisseria meningitidis in different strains of elderly mice. (AU)

Scientific publications

(13)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CORREA, VICTOR ARAUJO; PORTILHO, AMANDA IZELI; DE GASPARI, ELIZABETH. Immunological Effects of Dimethyldioctadecylammonium Bromide and Saponin as Adjuvants for Outer Membrane Vesicles from Neisseria meningitidis. DISEASES, v. 10, n. 3, p. 17-pg., 2022-09-01. (12/15568-0, 19/02042-9, 18/04202-0)

CORREA, VICTOR ARAUJO; RODRIGUES, THAIS SOUSA; PORTILHO, AMANDA IZELI; LIMA, GABRIELA TRZEWIKOSWKI DE; DE GASPARI, ELIZABETH. Modified ELISA for antibody avidity evaluation: The need for standardization. BIOMEDICAL JOURNAL, v. 44, n. 4, p. 433-438, AUG 2021. (18/17945-1, 19/02042-9, 13/11147-2, 18/04202-0, 12/15568-0)

PORTILHO, AMANDA IZELI; CORREA, VICTOR ARAUJO; CIRQUEIRA, CINTHYA DOS SANTOS; DE GASPARI, ELIZABETH. Intranasal and Intramuscular Immunization with Outer Membrane Vesicles from Serogroup C Meningococci Induced Functional Antibodies and Immunologic Memory. IMMUNOLOGICAL INVESTIGATIONS, v. 51, n. 7, p. 20-pg., 2022-08-12. (18/04202-0, 12/15568-0, 19/02042-9)

GASPAR, EMANUELLE B.; PRUDENCIO, CARLOS ROBERTO; DE GASPARI, ELIZABETH. Experimental studies using OMV in a new platform do SARS-CoV-2 vaccines. HUMAN VACCINES & IMMUNOTHERAPEUTICS, v. 17, n. 9, p. 2965-2968, SEP 2 2021. (18/04202-0, 12/15568-0)

PORTILHO, AMANDA IZELI; SANTOS, JESSICA SILVA; DE LIMA, GABRIELA TRZEWIKOSWKI; LIMA, GABRIELLE GIMENES; DE GASPARI, ELIZABETH. Study of avidity-ELISA: Comparison of chaotropic agents, incubation temperature and affinity maturation after meningococcal immunization. JOURNAL OF IMMUNOLOGICAL METHODS, v. 512, p. 6-pg., 2023-01-01. (18/04202-0)

DE LIMA, GABRIELA TRZEWIKOSWKI; RODRIGUES, THAIS SOUSA; PORTILHO, AMANDA IZELI; CORREA, VICTOR ARAUJO; GASPAR, EMANUELLE BALDO; DE GASPARI, ELIZABETH. Immune responses of meningococcal B outer membrane vesicles in middle-aged mice. PATHOGENS AND DISEASE, v. 78, n. 5, JUL 2020. (18/17945-1, 19/02042-9, 12/15568-0, 13/11147-2, 18/04202-0)

DE LIMA, GABRIELA TRZEWIKOSWKI; DE GASPARI, ELIZABETH. Study of the Immune Response in the Elderly: Is It Necessary to Develop a Vaccine against Neisseria meningitidis for the Aged?. JOURNAL OF AGING RESEARCH, v. 2019, p. 8-pg., 2019-01-01. (13/11147-2, 18/17945-1, 18/04202-0, 12/15568-0)

MOURA, ANDREW D.; DA COSTA, HERNAN H. M.; CORREA, VICTOR A.; LIMA, ANA K. DE S.; LINDOSO, JOSE A. L.; DE GASPARI, ELIZABETH; HONG, MARISA A.; CUNHA-JUNIOR, JAIR P.; PRUDENCIO, CARLOS R.. Assessment of avidity related to IgG subclasses in SARS-CoV-2 Brazilian infected patients. SCIENTIFIC REPORTS, v. 11, n. 1, SEP 3 2021. (17/50333-7, 18/04202-0)

LIMA, GABRIELLE GIMENES; PORTILHO, AMANDA IZELI; DE GASPARI, ELIZABETH. Adjuvants to increase immunogenicity of SARS-CoV-2 RBD and support maternal-fetal transference of antibodies in mice. PATHOGENS AND DISEASE, v. 80, n. 1, p. 13-pg., 2022-10-19. (18/04202-0)

PORTILHO, AMANDA IZELI; LIMA, GABRIELLE GIMENES; DE GASPARI, ELIZABETH. Enzyme-Linked Immunosorbent Assay: An Adaptable Methodology to Study SARS-CoV-2 Humoral and Cellular Immune Responses. JOURNAL OF CLINICAL MEDICINE, v. 11, n. 6, p. 13-pg., 2022-03-01. (18/04202-0)

PORTILHO, AMANDA IZELI; LIMA, GABRIELLE GIMENES; DE GASPARI, ELIZEBETH. SARS-CoV-2 vaccines: Potential refinements through induction of mucosal and trained immunity. Clinics, v. 77, p. 2-pg., 2022-01-01. (18/04202-0)

GASPAR, EMANUELLE BALDO; DE GASPARI, ELIZABETH. Avidity assay to test functionality of anti-SARS-Cov-2 antibodies. Vaccine, v. 39, n. 10, p. 3-pg., 2021-02-22. (18/04202-0, 13/11147-2, 12/15568-0)

LIMA, GABRIELLE GIMENES; PORTILHO, AMANDA IZELI; DE GASPARI, ELIZABETH. Animal Models to Test SARS-CoV-2 Vaccines: Which Ones Are in Use and Future Expectations. PATHOGENS, v. 12, n. 1, p. 16-pg., 2023-01-01. (18/04202-0)