Phenotypic and immunological characterization of clinical isolates of Aspergillus nidulans

• Grant number: 18/09602-7
• Support Opportunities: Research Grants - Visiting Researcher Grant - International
• Start date: August 01, 2018
• End date: September 07, 2018
• Field of knowledge: Biological Sciences - Genetics - Molecular Genetics and Genetics of Microorganisms
• Principal Investigator: Gustavo Henrique Goldman
• Grantee: Gustavo Henrique Goldman
• Visiting researcher: David Canovas Lopez
• Visiting researcher institution: Universidad de Sevilla (US), Spain
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Aspergillus species are excellent friends of humans but also terrible foes. They are responsible for more than 200,000 cases of invasive aspergillosis per year. The host laboratory has recently identified 10 clinical isolates as A. nidulans and is performing the characterization of their genome. This proposal aims to bring together the expertise of both laboratories to perform a deeper characterization of these isolates. In addition, the visitor is bringing 9-10 new clinical isolates, which will be included in the study to broaden our knowledge of the differences between clinical and non-clinical isolates. We expect that this will allow us to deepen the current knowledge of what makes a microorganism pathogenic. (AU)