Advanced search
Start date
Betweenand

Evaluation of avian infection (Gallus gallus domesticus) by Salmonella enteritidis, Salmonella typhimurium and Salmonella heidelberg containing deletion of the ttrA and pduA genes

Grant number: 18/03189-0
Support type:Research Projects - Thematic Grants
Duration: August 01, 2018 - July 31, 2023
Field of knowledge:Agronomical Sciences - Veterinary Medicine
Principal Investigator:Angelo Berchieri Junior
Grantee:Angelo Berchieri Junior
Home Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
Associated scholarship(s):19/01809-4 - Evaluation of intestinal colonization and systemic infection of mutant strains of S. Enteritidis (SE”ttrA”pduA), S. Typhimurium (STM”ttrA”pduA) e S. Heidelberg (SH”ttrA”pduA) in chicken (Gallus gallus domesticus), BP.IC
18/21301-2 - Evaluation of avian infection (Gallus gallus domesticus) by Salmonella enteritidis, Salmonella typhimurium and Salmonella heidelberg containing deletion of the ttrA and pduA genet, BP.PD
18/19438-0 - Fecal excretion of mutant strains of S. Enteritidis (SE”ttrA”pduA), S. Typhimurium (STM”ttrA”pduA) and S. Heidelberg (SH”ttrA”pduA) in chicken (Gallus gallus domesticus), BP.TT

Abstract

Assays done in mammals has shown that enteric salmonellas are able to use the inflammatory process provoked by them as a source of energy to survive and multiply inside the gut. This process is associated with the use of tetrathionate (ttr) as a by-product of the host inflammatory gut response. After the production of tetrathionate it becomes possible to use propanediol (pdu) as an energy source. Therefore, the intestinal inflammatory response of the host promotes efficient bacterial multiplication in the intestinal lumen, with consequent colonization and fecal-oral transmission. Poultry products have been associated with human foodborne diseases. Most of them caused by Salmonella enteritidis (SE) and Salmonella typhimurium (ST). In the last years, the European Community has rejected several poultry products from Brazil because they were contaminated by Salmonella heidelberg (SH). In view of the importance of poultry foods in foodborne salmonellosis we will investigate the relevance of genes related to tetrathionate and ethanolamine metabolism to the intestinal colonization of Salmonella in chickens. It is proposed the construction of mutant strains of SE, ST and SH containing deletions in the genes ttrA and pduA, to assess their behavior during the infection. The knowledge acquired may help to better understand the relationship between the bacteria and the host, contributing to a better understanding of bacterial behaviour and the search for alternatives to inhibit intestinal survival and colonization. (AU)

Articles published in Agência FAPESP Newsletter about the research grant
Genetic study seeks to prevent foodborne infection caused by <i>Salmonella</i>  
Distribution map of accesses to this page
Click here to view the access summary to this page.