Corticobasal syndrome: clinical and physiopathological correlates

• Grant number: 17/10033-4
• Support Opportunities: Regular Research Grants
• Duration: August 01, 2018 - July 31, 2020
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Sonia Maria Dozzi Brucki
• Grantee: Sonia Maria Dozzi Brucki
• Host Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Artur Martins Novaes Coutinho ; Carlos Alberto Buchpiguel ; Claudia da Costa Leite ; Jacy Bezerra Parmera

Abstract

Corticobasal syndrome (CBS) is an atypical parkinsonian syndrome of great interest to movement disorders specialists and behavioral neurologists. Although originally considered a primary motor disorder, it is now also recognized as a cognitive disorder, usually presenting cognitive deficits before the onset of motor symptoms. The term CBS denotes the clinical phenotype and is associated with a heterogeneous spectrum of pathologies. Given that disease-modifying agents are targeting the pathologic process, new diagnostic methods and biomarkers are being developed to predict the underlying pathology. Objectives: To analyse a cohort of patients with CBS through neuropsychological and neurological assessment to evaluate the presence of biomarkers to amyloid(utilizing Positron Emission Tomography with Pitsburg compound) and Tau pathology (Positron Emission Tomography with deoxy- fluoro- glucose and Magnetic Ressonance Imaging). Methods: these patients will be assessed longitudinally in the movement disorders and behavioral neurology outpatient service of Hospital das Clínicas, University of São Paulo. They will be compared to purpose a correlation between clinical assessment and biomarkers of Tau and Amyloid pathology. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PARMERA, JACY BEZERRA; COUTINHO, ARTUR MARTINS; ARANHA, MATEUS ROZALEM; STUDART-NETO, ADALBERTO; DE GODOI CARNEIRO, CAMILA; DE ALMEIDA, ISABEL JUNQUEIRA; FONTOURA SOLLA, DAVI J.; ONO, CARLA RACHEL; BARBOSA, EGBERTO REIS; NITRINI, RICARDO; et al. FDG-PET Patterns Predict Amyloid Deposition and Clinical Profile in Corticobasal Syndrome. MOVEMENT DISORDERS, NOV 2020. (17/10033-4)

PARMERA, JACY BEZERRA; DE ALMEIDA, ISABEL JUNQUEIRA; BARBOSA DE OLIVEIRA, MARCOS CASTELLO; SILAGI, MARCELA LIMA; CARNEIRO, CAMILA DE GODOI; STUDART-NETO, ADALBERTO; ONO, CARLA RACHEL; BARBOSA, EGBERTO REIS; NITRINI, RICARDO; BUCHPIGUEL, CARLOS ALBERTO; et al. Metabolic and Structural Signatures of Speech and Language Impairment in Corticobasal Syndrome: A Multimodal PET/MRI Study. FRONTIERS IN NEUROLOGY, v. 12, AUG 30 2021. (17/10033-4)

PARMERA, JACY BEZERRA; BRUCKI, SONIA MARIA DOZZI; COUTINHO, ARTUR MARTINS; NITRINI, RICARDO. Foot-Hand Synkinesis in Corticobasal Syndrome: Single Clinical Feature with Distinct Molecular Imaging Biomarkers. MOVEMENT DISORDERS CLINICAL PRACTICE, v. 8, n. 3, MAR 2021. (17/10033-4)