Agriculture, micro/nanotechnology and environment: from evaluation of the mechanisms of action to studies of transport and toxicity

• Grant number: 17/21004-5
• Support Opportunities: Research Projects - Thematic Grants
• Start date: September 01, 2018
• End date: February 29, 2024
• Field of knowledge: Biological Sciences - Biochemistry - Chemistry of Macromolecules
• Principal Investigator: Leonardo Fernandes Fraceto
• Grantee: Leonardo Fernandes Fraceto
• Host Institution: Instituto de Ciência e Tecnologia. Universidade Estadual Paulista (UNESP). Campus de Sorocaba. Sorocaba , SP, Brazil
• Pesquisadores principais: Ricardo Antonio Polanczyk
• Associated researchers: Alejandra Bravo ; Carlos Alberto Pérez ; Claudia Bueno dos Reis Martinez ; Claudio Martin Jonsson ; Daiana Silva de Ávila ; Gerson Araujo de Medeiros ; Halley Caixeta de Oliveira ; Juliana Lischka Sampaio Mayer ; Luciana de Matos Alves Pinto ; Marcelo Bispo de Jesus ; Renata de Lima ; Renato Grillo ; Ricardo Antonio Polanczyk ; Vera Lucia Scherholz Salgado de Castro
• Associated research grant(s): 23/00285-7 - Unraveling carbon-based nanomaterial fate in plants for safer agricultural practices, AP.R SPRINT
• Associated scholarship(s): 23/05321-1 - Development of Nanoformulations containing Essential Oils to control nematodes in Agriculture, BP.MS; 22/02559-4 - Lignin nanoparticles (NPLs) encapsulating AIA: potential use and its influence on morphophysiology in crops of economic interest, BP.DR; 22/11889-8 - Development of natural nanoherbicides and the study of mechanisms of toxicity and activity, BP.PD; + associated scholarships 22/02578-9 - Synthesis of biogenic silver and iron nanoparticles using plant growth-promoting bacteria for use in agriculture, BP.DR; 22/11656-3 - Application of lignin nanoparticles containing auxin in cherry tomato (Solanum lycopersicum) seeds: morphometric, anatomical and physiological analyses., BP.IC; 21/12643-0 - Association of biogenic silica nanoparticles obtained from rice husk as a strategy to increase the bioavailability of Beauveria bassiana for pest control, BP.PD; 20/12769-0 - Gold nanoparticles encapsulated in nanocarriers of pesticide as a potential label for understanding its fate in plants, BP.IC; 20/05816-2 - Study of the capping of biogenic nanoparticles and their correlation with toxicity and activity in the control of phytopathogens, BP.PD; 19/22360-5 - Encapsulation of Beauveria bassiana (Hypocreales: Cordycipitaceae) in polymeric microparticles by spray-drying technique to control Tetranychus urticae (Acari: Tetranichydae), BP.IC; 18/21142-1 - Encapsulation of Bacillus thuringiensis (Bacillales: Bacillaceae) in polymeric microparticles and association with nanoencapsulated chemical agent: evaluation of biological activity and mechanisms of action, BP.PD; 19/14829-3 - Study of the interaction of pesticides and nanopesticides with soil, BP.IC; 19/12257-2 - Evaluation of environmental security of nanoatrazine and azadiractin, BP.TT; 18/23608-8 - Development of labelled nanopesticides aiming studies of mechanism of action and toxicity, BP.PD - associated scholarships

Abstract

Modern agriculture can no longer be based on the intensive use of agricultural inputs that affect the environment. In this way, researchers, farmers and consumers must evolve towards ecologically and economically satisfactory production, in addition, new technologies must be adopted in order to optimize productivity while maintaining sustainable environment base. In this sense, there is a search for more sustainable practices to meet the premises of integrated pest and disease management in agriculture. Based on this scenario, this thematic proposal aims to elucidate the mechanisms of action and toxicity of systems based on micro and nanotechnology for pest control in agriculture, as well as to study the fate of these systems in the environment, with the intention of producing scientific knowledge necessary for understanding of the phenomena and processes that govern its biological activity. It should be emphasized that the present project has a strong multiplier character in the area of micro/nanotechnology in the scientific environment, due to the large number of research groups and institutions involved with the topic. In addition to the proposed scientific impact, we emphasize that the proposal, due to the participation of researchers, teachers, undergraduate and graduate students, will certainly have a great impact on the dissemination and improvement of the methods used, aiming at the use of more sustainable practices for pest control and diseases in agriculture. (AU)

Scientific publications

(67)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GUILGER-CASAGRANDE, MARIANA; GERMANO-COSTA, TAIS; BILESKY-JOSE, NATALIA; PASQUOTO-STIGLIANI, TATIANE; CARVALHO, LUCAS; FRACETO, LEONARDO F.; DE LIMA, RENATA. Influence of the capping of biogenic silver nanoparticles on their toxicity and mechanism of action towards Sclerotinia scierotiorum. JOURNAL OF NANOBIOTECHNOLOGY, v. 19, n. 1, FEB 24 2021. (16/13692-6, 18/23608-8, 17/20932-6, 17/13328-5, 20/05816-2, 17/21004-5)

DE ALBUQUERQUE, FELICIA PEREIRA; DE OLIVEIRA, JHONES LUIZ; MOSCHINI-CARLOS, VIVIANE; FRACETO, LEONARDO FERNANDES. An overview of the potential impacts of atrazine in aquatic environments: Perspectives for tailored solutions based on nanotechnology. Science of The Total Environment, v. 700, JAN 15 2020. (18/21142-1, 17/21004-5)

TESSER, MARIA EDUARDA; DE PAULA, ANGELICA ALVES; RISSO, WAGNER EZEQUIEL; MONTEIRO, RENATA APARECIDA; SANTO PEREIRA, ANDERSON DO ESPIRITO; FRACETO, LEONARDO FERNANDES; DOS REIS MARTINEZ, CLAUDIA BUENO. Sublethal effects of waterborne copper and copper nanoparticles on the freshwater Neotropical teleost Prochilodus lineatus: A comparative approach. Science of The Total Environment, v. 704, FEB 20 2020. (17/21004-5)

PREISLER, ANA C.; PEREIRA, ANDERSON E. S.; CAMPOS, ESTEFANIA V. R.; DALAZEN, GILIARDI; FRACETO, LEONARDO F.; OLIVEIRA, HALLEY C.. Atrazine nanoencapsulation improves pre-emergence herbicidal activity against Bidens pilosa without enhancing long-term residual effect on Glycine max. Pest Management Science, v. 76, n. 1, p. 141-149, JAN 2020. (17/21004-5)

LUIS, ANGELICA I. S.; CAMPOS, ESTEFANIA V. R.; DE OLIVEIRA, JHONES L.; GUILGER-CASAGRANDE, MARIANA; DE LIMA, RENATA; CASTANHA, RODRIGO F.; DE CASTRO, VERA L. S. S.; FRACETO, LEONARDO F.. Zein Nanoparticles Impregnated with Eugenol and Garlic Essential Oils for Treating Fish Pathogens. ACS OMEGA, v. 5, n. 25, p. 15557-15566, JUN 30 2020. (17/21004-5)

WU, JUAN; ZHAI, YUJIA; MONIKH, FAZEL ABDOLAHPUR; ARENAS-LAGO, DANIEL; GRILLO, RENATO; VIJVER, MARTINA G.; PEIJNENBURG, WILLIE J. G. M.. The Differences between the Effects of a Nanoformulation and a Conventional Form of Atrazine to Lettuce: Physiological Responses, Defense Mechanisms, and Nutrient Displacement. Journal of Agricultural and Food Chemistry, v. 69, n. 42, p. 12527-12540, OCT 27 2021. (17/21004-5)

BILESKY-JOSE, NATALIA; MARUYAMA, CINTIA; GERMANO-COSTA, TAIS; CAMPOS, ESTEFANIA; CARVALHO, LUCAS; GRILLO, RENATO; FRACETO, LEONARDO FERNANDES; DE LIMA, RENATA. Biogenic alpha-Fe2O3 Nanoparticles Enhance the Biological Activity of Trichoderma against the Plant Pathogen Sclerotinia sclerotiorum. ACS SUSTAINABLE CHEMISTRY & ENGINEERING, v. 9, n. 4, p. 1669-1683, FEB 1 2021. (18/23608-8, 17/21004-5, 17/20932-6)

GOMES, SUSANA I. L.; CAMPOS, ESTEFANIA V. R.; FRACETO, LEONARDO F.; GRILLO, RENATO; SCOTT-FORDSMAND, JANECK J.; AMORIM, MONICA J. B.. High-throughput transcriptomics reveals the mechanisms of nanopesticides - nanoformulation, commercial formulation, active ingredient - finding safe and sustainable-by-design (SSbD) options for the environment. ENVIRONMENTAL SCIENCE-NANO, v. 9, n. 6, p. 13-pg., 2022-05-04. (17/21004-5, 17/24402-1)

PEREIRA, ANDERSON DO ESPIRITO SANTO; DE OLIVEIRA, JHONES LUIZ; SAVASSA, SUSILAINE MAIRA; ROGERIO, CAROLINA BARBARA; DE MEDEIROS, GERSON ARAUJO; FRACETO, LEONARDO FERNANDES. Lignin nanoparticles: New insights for a sustainable agriculture. JOURNAL OF CLEANER PRODUCTION, v. 345, p. 16-pg., 2022-04-15. (17/21004-5, 18/21142-1, 20/12779-6, 20/05415-8)

TAKESHITA, VANESSA; MUNHOZ-GARCIA, GUSTAVO VINICIOS; PINACIO, CAMILA WERK; CARDOSO, BRIAN CINTRA; NALIN, DANIEL; TORNISIELO, VALDEMAR LUIZ; FRACETO, LEONARDO FERNANDES. Availability of Metribuzin-Loaded Polymeric Nanoparticles in Different Soil Systems: An Important Study on the Development of Safe Nanoherbicides. PLANTS-BASEL, v. 11, n. 23, p. 17-pg., 2022-12-01. (22/00718-8, 19/04758-1, 17/21004-5, 21/03455-5, 22/01554-9)

MONTEIRO, RENATA APARECIDA; CAMARA, MARCELA CANDIDO; DE OLIVEIRA, JHONES LUIZ; RAMOS CAMPOS, ESTEFANIA VANGELIE; CARVALHO, LUCAS BRAGANCA; DE FREITAS PROENCA, PATRICIA LUIZA; GUILGER-CASAGRANDE, MARIANA; LIMA, RENATA; DO NASCIMENTO, JOACIR; GONCALVES, KELLY CRISTINA; et al. Zein based-nanoparticles loaded botanical pesticides in pest control: An enzyme stimuli-responsive approach aiming sustainable agriculture. JOURNAL OF HAZARDOUS MATERIALS, v. 417, SEP 5 2021. (17/21004-5, 17/13328-5, 18/21142-1, 18/23608-8, 20/05816-2)

DE OLIVEIRA, JHONES L.; CAMPOS, ESTEFANIA V. R.; GERMANO-COSTA, TAIS; LIMA, RENATA; DELLA VECHIA, JAQUELINE FRANCIOSI; SOARES, SIDNEIA TEREZINHA; DE ANDRADE, DANIEL JUNIOR; GONCALVES, KELLY CRISTINA; DO NASCIMENTO, JOACIR; POLANCZYK, RICARDO ANTONIO; et al. Association of zein nanoparticles with botanical compounds for effective pest control systems. Pest Management Science, v. 75, n. 7, p. 1855-1865, JUL 2019. (17/21004-5, 14/20286-9)

BARTOLUCCI, CECILIA; ANTONACCI, AMINA; ARDUINI, FABIANA; MOSCONE, DANILA; FRACETO, LEONARDO; CAMPOS, ESTEFANIA; ATTAALLAH, RAOUIA; AMINE, AZIZ; ZANARDI, CHIARA; CUBILLANA-AGUILERA, LAURA M.; et al. Green nanomaterials fostering agrifood sustainability. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 125, APR 2020. (19/05100-0, 17/21004-5, 17/24402-1)

SANTOS, E.; MONTANHA, G. S.; GOMES, M. H. F.; DURAN, N. M.; CORREA, C. G.; ROMEU, S. L. Z.; PEREIRA, A. E. S.; OLIVEIRA, J. L.; ALMEIDA, E.; PEREZ-DE-LUQUE, A.; et al. Are nanomaterials leading to more efficient agriculture? Outputs from 2009 to 2022 research metadata analysis. ENVIRONMENTAL SCIENCE-NANO, v. 9, n. 10, p. 14-pg., 2022-08-19. (20/11178-9, 17/16375-4, 16/50014-6, 17/21004-5, 20/11546-8, 20/07721-9)

SANTO PEREIRA, ANDERSON DO ESPIRITO; OLIVEIRA, HALLEY CAIXETA; FRACETO, LEONARDO FERNANDES. Polymeric nanoparticles as an alternative for application of gibberellic acid in sustainable agriculture: a field study. SCIENTIFIC REPORTS, v. 9, MAY 9 2019. (17/21004-5)

MUJTABA, MUHAMMAD; KHAWAR, KHALID MAHMOOD; CAMARA, MARCELA CANDIDO; CARVALHO, LUCAS BRAGANCA; FRACETO, LEONARDO FERNANDES; MORSI, RANIA E.; ELSABEE, MAHER Z.; KAYA, MURAT; LABIDI, JALEL; ULLAH, HIDAYAT; et al. Chitosan-based delivery systems for plants: A brief overview of recent advances and future directions. International Journal of Biological Macromolecules, v. 154, p. 683-697, JUL 1 2020. (18/23608-8, 17/21004-5)

SOUSA, BRUNO TEIXEIRA; SANTO PEREIRA, ANDERSON DO ESPIRITO; FRACETO, LEONARDO FERNANDES; DE OLIVEIRA, HALLEY CAIXETA; DALAZEN, GILIARDI. Effectiveness of nanoatrazine in post-emergent control of the tolerant weed Digitaria insularis. JOURNAL OF PLANT PROTECTION RESEARCH, v. 60, n. 2, p. 8-pg., 2020-01-01. (17/21004-5)

ZHAI, YUJIA; ABDOLAHPUR MONIKH, FAZEL; WU, JUAN; GRILLO, RENATO; ARENAS-LAGO, DANIEL; DARBHA, GOPALA KRISHNA; VIJVER, MARTINA G.; PEIJNENBURG, WILLIE J. G. M.. Interaction between a nano-formulation of atrazine and rhizosphere bacterial communities: atrazine degradation and bacterial community alterations. ENVIRONMENTAL SCIENCE-NANO, v. 7, n. 11, p. 3372-3384, NOV 1 2020. (17/21004-5)

GRILLO, RENATO; FRACETO, LEONARDO F.; AMORIM, MONICA J. B.; SCOTT-FORDSMAND, JANECK JAMES; SCHOONJANS, REINHILDE; CHAUDHRY, QASIM. Ecotoxicological and regulatory aspects of environmental sustainability of nanopesticides. JOURNAL OF HAZARDOUS MATERIALS, v. 404, n. A, FEB 15 2021. (17/21004-5)

DE OLIVEIRA, JHONES L.; CAMPOS, ESTEFANIA V. R.; CAMARA, MARCELA CANDIDO; DELLA VECHIA, JAQUELINE FRANCIOSI; SOARES DE MATOS, SIDNEIA TEREZINHA; DE ANDRADE, DANIEL JUNIOR; GONCALVES, KELLY CRISTINA; DO NASCIMENTO, JOACIR; POLANCZYK, RICARDO ANTONIO; DE ARAUJO, DANIELE RIBEIRO; et al. Hydrogels Containing Botanical Repellents Encapsulated in Zein Nanoparticles for Crop Protection. ACS APPLIED NANO MATERIALS, v. 3, n. 1, p. 207-217, JAN 2020. (14/20286-9, 17/21004-5)

GUILGER-CASAGRANDE, MARIANA; GERMANO-COSTA, TAIS; PASQUOTO-STIGLIANI, TATIANE; FRACETO, LEONARDO FERNANDES; DE LIMA, RENATA. Biosynthesis of silver nanoparticles employing Trichoderma harzianum with enzymatic stimulation for the control of Sclerotinia sclerotiorum. SCIENTIFIC REPORTS, v. 9, OCT 4 2019. (16/13692-6, 17/13328-5, 17/21004-5)

TESSER, MARIA EDUARDA; GUILGER, MARIANA; BILESKY-JOSE, NATALIA; RISSO, WAGNER EZEQUIEL; DE LIMA, RENATA; DOS REIS MARTINEZ, CLAUDIA BUENO. Biogenic metallic nanoparticles (Ag, TiO2, Fe) as potential fungicides for agriculture: are they safe for the freshwater mussel Anodontites trapesialis?. Chemosphere, v. 309, p. 11-pg., 2022-10-06. (17/21004-5)

BARTOLUCCI, CECILIA; SCOGNAMIGLIO, VIVIANA; ANTONACCI, AMINA; FRACETO, LEONARDO FERNANDES. What makes nanotechnologies applied to agriculture green?. NANO TODAY, v. 43, p. 5-pg., 2022-01-10. (17/21004-5)

SARAIVA, NARIANI ROCHA; RONCATO, JULIANA FOLETTO FREDO; PASCOLI, MONICA; MACEDO E SOUSA, JOAO MARCOS FONSECA; WINDBERG, JR., LUIZ FELIPE; ROSSATTO, FERNANDA CRISTINA POSSAMAI; SOARES, JEFFERSON DE JESUS; DENARDIN, ELTON LUIS GASPAROTTO; PUNTEL, ROBSON LUIZ; ZIMMER, KARINE RIGON; et al. Clove oil-loaded zein nanoparticles as potential bioinsecticide agent with low toxicity. SUSTAINABLE CHEMISTRY AND PHARMACY, v. 24, DEC 2021. (17/21004-5, 15/17120-4)

MEIRELLES, LAURA NOBREGA; MESQUITA, EMILY; CORREA, THAIS ALMEIDA; BITENCOURT, RICARDO DE OLIVEIRA BARBOSA; OLIVEIRA, JHONES LUIZ; FRACETO, LEONARDO FERNANDES; CAMARGO, MARIANA GUEDES; BITTENCOURT, VANIA RITA ELIAS PINHEIRO. Encapsulation of entomopathogenic fungal conidia: evaluation of stability and control potential of Rhipicephalus microplus. TICKS AND TICK-BORNE DISEASES, v. 14, n. 4, p. 10-pg., 2023-04-25. (18/21142-1, 17/21004-5)

PASQUOTO-STIGLIANI, TATIANE; GUILGER-CASAGRANDE, MARIANA; CAMPOS, ESTEFANIA V. R.; GERMANO-COSTA, TAIS; BILESKY-JOSE, NATALIA; MIGLIORINI, BIANCA B.; FEITOSA, LEANDRO O.; SOUSA, BRUNO T.; DE OLIVEIRA, HALLEY C.; FRACETO, LEONARDO F.; et al. Titanium biogenic nanoparticles to help the growth of Trichoderma harzianum to be used in biological control. JOURNAL OF NANOBIOTECHNOLOGY, v. 21, n. 1, p. 21-pg., 2023-05-25. (16/13692-6, 20/05816-2, 17/13328-5, 17/21004-5)

BAIGORRIA, E.; DOS SANTOS, S. SOUZA; DE MOURA, M. R.; FRACETO, L. F.. Nanocomposite hydrogels 3D printed for application in water remediation. MATERIALS TODAY CHEMISTRY, v. 30, p. 14-pg., 2023-05-04. (13/07296-2, 19/06170-1, 17/21004-5)

PREISLER, ANA CRISTINA; CARVALHO, LUCAS BRAGANCA; SARAIVA-SANTOS, TELMA; VERRI JR, WALDICEU APARECIDO; SAMPAIO MAYER, JULIANA LISCHKA; FRACETO, LEONARDO FERNANDES; DALAZEN, GILIARDI; OLIVEIRA, HALLEY CAIXETA. Interaction of Nanoatrazine and Target Organism: Evaluation of Fate and Photosystem II Inhibition in Hydroponically Grown Mustard (Brassica juncea) Plants. Journal of Agricultural and Food Chemistry, v. 70, n. 25, p. 9-pg., 2022-06-08. (17/21004-5, 18/23608-8)

DE OLIVEIRA, JHONES LUIZ; DE OLIVEIRA, THAYLA NESPOLA; SAVASSA, SUSILAINE MAIRA; DELLA VECHIA, JAQUELINE FRANCIOSI; SOARES DE MATOS, SIDNEIA TEREZINHA; DE ANDRADE, DANIEL JUNIOR; FRACETO, LEONARDO FERNANDES. Encapsulation of Beauveria bassiana in Polysaccharide-Based Microparticles: A Promising Carrier System for Biological Control Applications. ACS AGRICULTURAL SCIENCE & TECHNOLOGY, v. 3, n. 9, p. 10-pg., 2023-09-06. (17/21004-5, 19/22360-5)

BOFF, JESSICA S.; REIS, ALEXANDRE C.; DE OLIVEIRA, JHONES L.; GROSS, RENATA B.; FRACETO, LEONARDO F.; MELO, ADRIANO A.; BERNARDI, ODERLEI. Development and biological evaluation of nanoencapsulated-based pyrethroids with synergists for resistance management of two soybean pests: insights for new insecticide formulations. Pest Management Science, v. 79, n. 3, p. 9-pg., 2022-11-29. (17/21004-5, 18/21142-1)

CARVALHO, LUCAS BRAGANCA; GODOY, ISABELA SILVA; PREISLER, ANA CRISTINA; PROENCA, PATRICIA LUIZA DE FREITAS; SARAIVA-SANTOS, TELMA; VERRI JR, WALDICEU APARECIDO; OLIVEIRA, HALLEY CAIXETA; DALAZEN, GILIARDI; FRACETO, LEONARDO FERNANDES. Pre-emergence herbicidal efficiency and uptake of atrazine-loaded zein nanoparticles: a sustainable alternative to weed control. ENVIRONMENTAL SCIENCE-NANO, v. 10, n. 6, p. 15-pg., 2023-04-21. (18/23608-8, 17/21004-5)

FORINI, MARIANA M. L.; ANTUNES, DEBORA R.; CAVALCANTE, LUIZ A. F.; PONTES, MONTCHARLES S.; BISCALCHIM, ERICA R.; SANCHES, ALEX O.; SANTIAGO, ETENALDO F.; FRACETO, LEONARDO F.; GRILLO, RENATO. Fabrication and Characterization of a Novel Herbicide Delivery System with Magnetic Collectability and Its Phytotoxic Effect on Photosystem II of Aquatic Macrophyte. Journal of Agricultural and Food Chemistry, v. 68, n. 40, p. 11105-11113, OCT 7 2020. (17/21004-5)

DE ALBUQUERQUE, FELICIA PEREIRA; DE OLIVEIRA, JHONES LUIZ; DOS SANTOS MACHADO, LEILA; RICHARDI, VINICIUS SOBRINHO; DA SILVA, MARIO ANTONIO NAVARRO; POMPEO, MARCELO LUIZ MARTINS; FRACETO, LEONARDO FERNANDES; CARLOS, VIVIANE MOSCHINI. Use of nontarget organism Chironomus sancticaroli to study the toxic effects of nanoatrazine. ECOTOXICOLOGY, v. 30, n. 4, p. 733-750, MAY 2021. (18/21142-1, 16/17266-1, 17/21004-5)

GRILLO, RENATO; MATTOS, BRUNO D.; ANTUNES, DEBORA R.; FORINI, MARIANA M. L.; MONIKH, FAZEL A.; ROJAS, ORLANDO J.. Foliage adhesion and interactions with particulate delivery systems for plant nanobionics and intelligent agriculture. NANO TODAY, v. 37, APR 2021. (20/12769-0, 17/21004-5)

DA SILVA, NATARA D. G.; CARNEIRO, CRISTIANE E. A.; CAMPOS, ESTEFANIA V. R.; DE OLIVEIRA, JHONES L.; RISSO, WAGNER E.; FRACETO, LEONARDO F.; ZAIA, DIMAS A. M.; MARTINEZ, CLAUDIA B. R.. Interference of goethite in the effects of glyphosate and Roundup (R) on ZFL cell line. TOXICOLOGY IN VITRO, v. 65, JUN 2020. (17/21004-5)

OLIVEIRA, C. R.; GARCIA, T. D.; FRANCO-BELUSSI, L.; SALLA, R. F.; SOUZA, B. F. S.; DE MELO, N. F. S.; IRAZUSTA, S. P.; JONES-COSTA, M.; SILVA-ZACARIN, E. C. M.; FRACETO, L. F.. Pyrethrum extract encapsulated in nanoparticles: Toxicity studies based on genotoxic and hematological effects in bullfrog tadpoles. Environmental Pollution, v. 253, p. 1009-1020, OCT 2019. (17/21004-5)

PASCOLI, MONICA; JACQUES, MAURICIO T.; AGARRAYUA, DANIELLE A.; AVILA, DAIANA S.; LIMA, RENATA; FRACETO, LEONARDO F.. Neem oil based nanopesticide as an environmentally-friendly formulation for applications in sustainable agriculture: An ecotoxicological perspective. Science of The Total Environment, v. 677, p. 57-67, AUG 10 2019. (15/17120-4, 17/21004-5)

BOMBO, ALINE BERTOLOSI; SANTO PEREIRA, ANDERSON ESPIRITO; LUSA, MAKELI GARIBOTTI; OLIVEIRA, ELIANA DE MEDEIROS; DE OLIVEIRA, JHONES LUIS; RAMOS CAMPOS, ESTEFANIA VANGELIE; DE JESUS, MARCELO BISPO; OLIVEIRA, HALLEY CAIXETA; FRACETO, LEONARDO FERNANDES; SAMPAIO MAYER, JULIANA LISCHKA. A Mechanistic View of Interactions of a Nanoherbicide with Target Organism. Journal of Agricultural and Food Chemistry, v. 67, n. 16, p. 4453-4462, APR 24 2019. (17/21004-5)

PASCOLI, MONICA; DE ALBUQUERQUE, FELICIA PEREIRA; CALZAVARA, ANDERSON KIKUCHI; TINOCO-NUNES, BRUNO; CRUZ OLIVEIRA, WANDERSON HENRIQUE; GONCALVES, KELLY CRISTINA; POLANCZYK, RICARDO ANTONIO; DELLA VECHIA, JAQUELINE FRANCIOSI; SOARES DE MATOSS, SIDNEIA TEREZINHA; DE ANDRADE, DANIEL JUNIOR; et al. The potential of nanobiopesticide based on zein nanoparticles and neem oil for enhanced control of agricultural pests. JOURNAL OF PEST SCIENCE, v. 93, n. 2, JAN 2020. (15/17120-4, 13/11343-6, 17/21004-5)

GOMES, SUSANA I. L.; SCOTT-FORDSMAND, JANECK J.; CAMPOS, ESTEFANIA V. R.; GRILLO, RENATO; FRACETO, LEONARDO F.; AMORIM, MONICA J. B.. On the safety of nanoformulations to non-target soil invertebrates - an atrazine case study. ENVIRONMENTAL SCIENCE-NANO, v. 6, n. 6, p. 1950-1958, JUN 1 2019. (17/21004-5)

CAMPOS, ESTEFANIA V. R.; PEREIRA, ANDERSON E. S.; DE OLIVEIRA, JHONES LUIZ; CARVALHO, LUCAS BRAGANCA; GUILGER-CASAGRANDE, MARIANA; DE LIMA, RENATA; FRACETO, LEONARDO FERNANDES. How can nanotechnology help to combat COVID-19? Opportunities and urgent need. JOURNAL OF NANOBIOTECHNOLOGY, v. 18, n. 1, SEP 5 2020. (17/21004-5, 19/05100-0, 18/21142-1, 18/23608-8, 20/05816-2, 17/24402-1)

MARUYAMA, CINTIA RODRIGUES; BILESKY-JOSE, NATALIA; DE LIMA, RENATA; FRACETO, LEONARDO FERNANDES. Encapsulation of Trichoderma harzianum Preserves Enzymatic Activity and Enhances the Potential for Biological Control. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, v. 8, MAR 25 2020. (17/21004-5, 15/18231-4)

TAKESHITA, VANESSA; DE SOUSA, BRUNO TEIXEIRA; PREISLER, ANA CRISTINA; CARVALHO, LUCAS BRAGANCA; SANTO PEREIRA, ANDERSON DO ESPIRITO; TORNISIELO, VALDEMAR LUIZ; DALAZEN, GILIARDI; OLIVEIRA, HALLEY CAIXETA; FRACETO, LEONARDO FERNANDES. Foliar absorption and field herbicidal studies of atrazine-loaded polymeric nanoparticles. JOURNAL OF HAZARDOUS MATERIALS, v. 418, SEP 15 2021. (19/04758-1, 18/23608-8, 17/21004-5)

SANTO PEREIRA, ANDERSON DO ESPIRITO; OLIVEIRA, HALLEY CAIXETA; FRACETO, LEONARDO FERNANDES; SANTAELLA, CATHERINE. Nanotechnology Potential in Seed Priming for Sustainable Agriculture. NANOMATERIALS, v. 11, n. 2, FEB 2021. (17/21004-5)

FIGUEIREDO, AMANDA; ANHOLETO, LUIS ADRIANO; COLA, DIEGO FARIA; FANTATTO, RAFAELA REGINA; SANTOS, ISABELLA BARBOSA; GAINZA, YOUSMEL ALEMAN; SOUSA, GUSTAVO AVELAR; PICKETT, LAURA JANE; FRACETO, LEONARDO FERNANDES; CHAGAS, ANA CAROLINA DE SOUZA. Nanoformulations with synthetic and plant-derived compounds for cattle tick control. Veterinary Parasitology, v. 309, p. 9-pg., 2022-09-01. (17/21004-5, 19/20185-1, 17/13249-8)

OLIVEIRA, CRISTIANE R.; DOMINGUES, CAIO E. C.; DE MELO, NATHALIE F. S.; ROAT, THAISA C.; MALASPINA, OSMAR; JONES-COSTA, MONICA; SILVA-ZACARIN, ELAINE C. M.; FRACETO, LEONARDO F.. Nanopesticide based on botanical insecticide pyrethrum and its potential effects on honeybees. Chemosphere, v. 236, DEC 2019. (17/21004-5, 15/01424-4)

BAIGORRIA, ESTEFANIA; FRACETO, LEONARDO F.. Low-cost biosorbent hybrid hydrogels for paraquat remediation of water. JOURNAL OF WATER PROCESS ENGINEERING, v. 49, p. 13-pg., 2022-08-29. (17/21004-5)

CARVALHO, LUCAS BRAGANCA; VENCESLAU, ADNEIA DE FATIMA ABREU; BREISCH, DANIELA LUZ AMBROSIO; FRACETO, LEONARDO FERNANDES; JAIME, CARLOS; PINTO, LUCIANA MATOS ALVES. Heterocyclic agrochemical hosted by cyclodextrin and hybrid cyclodextrin-silica materials: Characterization, release behavior, and mobility in soil. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 656, p. 11-pg., 2023-01-05. (17/21004-5, 18/23608-8)

PONTES, MONTCHARLES S.; ANTUNES, DEBORA R.; OLIVEIRA, IVAN P.; FORINI, MARIANA M. L.; SANTOS, JAQUELINE S.; ARRUDA, GILBERTO J.; CAIRES, ANDERSON R. L.; SANTIAGO, ETENALDO F.; GRILLO, RENATO. Chitosan/tripolyphosphate nanoformulation carrying paraquat: insights on its enhanced herbicidal activity. ENVIRONMENTAL SCIENCE-NANO, v. 8, n. 5, p. 1336-1351, MAY 1 2021. (17/02201-4, 20/12769-0, 17/21004-5, 11/01872-6)

LUIS, ANGELICA I. S.; CAMPOS, ESTEFANIA V. R.; OLIVEIRA, JHONES L.; VALLIM, JOSE HENRIQUE; PROENCA, PATRICIA L. F.; CASTANHA, RODRIGO F.; DE CASTRO, VERA L. S. S.; FRACETO, LEONARDO F.. Ecotoxicity evaluation of polymeric nanoparticles loaded with ascorbic acid for fish nutrition in aquaculture. JOURNAL OF NANOBIOTECHNOLOGY, v. 19, n. 1, MAY 31 2021. (18/21142-1, 17/21004-5, 17/24402-1)

DE OLIVEIRA, JHONES L.; FRACETO, LEONARDO FERNANDES; BRAVO, ALEJANDRA; POLANCZYK, RICARDO ANTONIO. Encapsulation Strategies for Bacillus thuringiensis: From Now to the Future. Journal of Agricultural and Food Chemistry, v. 69, n. 16, p. 4564-4577, APR 28 2021. (20/12779-6, 18/21142-1, 17/21004-5)

CAMPOS, ESTEFANIA V. R.; PEREIRA, ANDERSON DO E. S.; ALEKSIEIENKO, IVAN; DO CARMO, GIOVANNA C.; GOHARI, GHOLAMREZA; SANTAELLA, CATHERINE; FRACETO, LEONARDO F.; OLIVEIRA, HALLEY C.. Encapsulated plant growth regulators and associative microorganisms: Nature-based solutions to mitigate the effects of climate change on plants. Plant Science, v. 331, p. 17-pg., 2023-04-01. (17/21004-5)

GUILGER-CASAGRANDE, MARIANA; BILESKY-JOSE, NATALIA; SOUSA, BRUNO TEIXEIRA; OLIVEIRA, HALLEY CAIXETA; FRACETO, LEONARDO FERNANDES; LIMA, RENATA. Effects of biogenic silver and iron nanoparticles on soybean seedlings (Glycine max). BMC PLANT BIOLOGY, v. 22, n. 1, p. 9-pg., 2022-05-24. (17/20932-6, 20/05816-2, 16/13692-6, 17/13328-5, 17/21004-5)

DE SOUSA, BRUNO TEIXEIRA; SANTO PEREIRA, ANDERSON DO ESPIRITO; FRACETO, LEONARDO FERNANDES; OLIVEIRA, HALLEY CAIXETA; DALAZEN, GILIARDI. Post-emergence herbicidal activity of nanoatrazine against Alternanthera tenella Colla plants compared to other weed species. HELIYON, v. 8, n. 7, p. 8-pg., 2022-07-19. (17/21004-5)

ANTONACCI, AMINA; FRISULLI, VALERIA; CARVALHO, LUCAS BRAGANCA; FRACETO, LEONARDO FERNANDES; MIRANDA, BRUNO; DE STEFANO, LUCA; JOHANNINGMEIER, UDO; GIARDI, MARIA TERESA; SCOGNAMIGLIO, VIVIANA. An All-Green Photo-Electrochemical Biosensor Using Microalgae Immobilized on Eco-Designed Lignin-Based Screen-Printed Electrodes to Detect Sustainable Nanoherbicides. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 24, n. 12, p. 12-pg., 2023-06-01. (18/23608-8, 17/21004-5)

CAMPOS, ESTEFANIA V. R.; RATKO, JONATHAN; BIDYARANI, NGANGOM; TAKESHITA, VANESSA; FRACETO, LEONARDO F.. Nature-Based Herbicides and Micro-/Nanotechnology Fostering Sustainable Agriculture. ACS SUSTAINABLE CHEMISTRY & ENGINEERING, v. 11, n. 27, p. 18-pg., 2023-06-26. (19/04758-1, 22/00509-0, 21/10639-5, 17/21004-5)

PROENCA, PATRICIA L. F.; CARVALHO, LUCAS B.; CAMPOS, ESTEFAENIA V. R.; FRACETO, LEONARDO F.. Fluorescent labeling as a strategy to evaluate uptake and transport of polymeric nanoparticles in plants. ADVANCES IN COLLOID AND INTERFACE SCIENCE, v. 305, p. 15-pg., 2022-07-01. (17/21004-5, 18/23608-8)

BAIGORRIA, ESTEFANIA; FRACETO, LEONARDO F.. Biopolymer-Nanocomposite Hybrid Materials as Potential Strategy to Remove Pesticides in Water: Occurrence and Perspectives. ADVANCED SUSTAINABLE SYSTEMS, v. 6, n. 1, OCT 2021. (17/21004-5)

BAIGORRIA, ESTEFANIA; FRACETO, LEONARDO F.. Novel nanostructured materials based on polymer/organic-clay composite networks for the removal of carbendazim from waters. JOURNAL OF CLEANER PRODUCTION, v. 331, p. 13-pg., 2022-01-10. (17/21004-5)

GALHARDI, JULIANA APARECIDA; DE OLIVEIRA, JHONES LUIZ; GHOSHAL, SUBHASIS; FRACETO, LEONARDO FERNANDES. Soil Enzyme Responses to Polymeric Nanopesticides: An Ecological Risk Analysis Approach to Promote Sustainable Agriculture. ACS AGRICULTURAL SCIENCE & TECHNOLOGY, v. 2, n. 3, p. 10-pg., 2022-06-20. (17/21004-5, 18/21142-1)

OLIVEIRA, HALLEY CAIXETA; SEABRA, AMEDEA BAROZZI; KONDAK, SELAHATTIN; ADEDOKUN, OLUWATOSIN PEACE; KOLBERT, ZSUZSANNA. Multilevel approach to plant-nanomaterial relationships: from cells to living ecosystems. Journal of Experimental Botany, v. 74, n. 12, p. 19-pg., 2023-03-22. (22/00321-0, 17/21004-5)

MUJTABA, MUHAMMAD; FRACETO, LEONARDO FERNANDES; FAZELI, MAHYAR; MUKHERJEE, SRITAMA; SAVASSA, SUSILAINE MAIRA; DE MEDEIROS, GERSON ARAUJO; SANTO PEREIRA, ANDERSON DO ESPIRITO; MANCINI, SANDRO DONNINI; LIPPONEN, JUHA; VILAPLANA, FRANCISCO. Lignocellulosic biomass from agricultural waste to the circular economy: a review with focus on biofuels, biocomposites and bioplastics. JOURNAL OF CLEANER PRODUCTION, v. 402, p. 23-pg., 2023-03-21. (17/21004-5)

FIGUEIREDO, AMANDA; ANHOLETO, LUIS ADRIANO; COLA, DIEGO FARIA; FANTATTO, RAFAELA REGINA; GAINZA, YOUSMEL ALEMAN; DOS SANTOS, ISABELLA BARBOSA; VICOZZI, GABRIEL PEDROSO; AVILA, DAIANA SILVA; FRACETO, LEONARDO FERNANDES; CHAGAS, ANA CAROLINA DE SOUZA. Acaricides containing zein nanoparticles: A tool for a lower impact control of the cattle tick Rhipicephalus microplus. Veterinary Parasitology, v. 318, p. 11-pg., 2023-04-11. (19/20185-1, 18/16070-1, 17/13249-8, 17/21004-5)

CASTANHA, RODRIGO FERNANDES; PEREIRA, ANDERSON DO ESPIRITO SANTO; VILLARREAL, GABRIELA PATRICIA UNIGARRO; VALLIM, JOSE HENRIQUE; PERTRINI, FERNANDA SANA; JONSSON, CLAUDIO MARTIN; FRACETO, LEONARDO FERNANDES; DE CASTRO, VERA LUCIA SCHERHOLZ SALGADO. Ecotoxicity studies of two atrazine nanoformulations: From the evaluation of stability in media to the effects on aquatic organisms. Environmental Pollution, v. 335, p. 9-pg., 2023-10-15. (17/21004-5)

MUJTABA, MUHAMMAD; WANG, DEPENG; CARVALHO, LUCAS BRAGANCA; OLIVEIRA, JHONES LUIZ; SANTO PEREIRA, ANDERSON DO ESPIRITO; SHARIF, RAHAT; JOGAIAH, SUDISHA; PAIDI, MURALI KRISHNA; WANG, LICHEN; ALI, QASID; et al. Nanocarrier-Mediated Delivery of miRNA, RNAi, and CRISPR-Cas for Plant Protection: Current Trends and Future Directions. ACS AGRICULTURAL SCIENCE & TECHNOLOGY, v. 1, n. 5, p. 19-pg., 2021-10-18. (17/21004-5, 18/21142-1, 18/23608-8)

SCOTT-FORDSMAND, J. J.; FRACETO, L. F.; AMORIM, M. J. B.. Nano-pesticides: the lunch-box principle-deadly goodies (semio-chemical functionalised nanoparticles that deliver pesticide only to target species) COMMENT. JOURNAL OF NANOBIOTECHNOLOGY, v. 20, n. 1, p. 9-pg., 2022-01-04. (17/21004-5)

MOORE, AMBER J. S.; DEAN, LAREB S. N.; YAM, AIKEN N. K.; DE LIMA, RENATA; FRACETO, LEONARDO F.; TETLEY, TERESA D.. Bioreactivity of a novel poly(epsilon-caprolactone) nanocapsule containing atrazine with human lung alveolar epithelial cells. ENVIRONMENTAL SCIENCE-NANO, v. 9, n. 6, p. 15-pg., 2022-04-28. (17/21004-5, 16/50003-4)

Filed patent(s) as a result of this research project