| Grant number: | 18/03511-0 |
| Support Opportunities: | Regular Research Grants |
| Start date: | September 01, 2018 |
| End date: | November 30, 2020 |
| Field of knowledge: | Biological Sciences - Physiology - Physiology of Organs and Systems |
| Principal Investigator: | Guiomar Nascimento Gomes |
| Grantee: | Guiomar Nascimento Gomes |
| Host Institution: | Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil |
Abstract
In the last decades there has been a great increase in the consumption of foods that present the fructose in its formulation. However, the high consumption of this sugar has been related to the development of diseases such as obesity, diabetes and others.It is known that the adequate maternal environment is vital to ensure normal fetal development and that alterations that influence this environment can modify the intrauterine development making the offspring more susceptible to the development of arterial hypertension and cardiovascular, renal and metabolic alterations at adulthood. Taking into account that high fructose consumption during pregnancy may alter the fetal environment, it is important to evaluate the impact of excessive fructose consumption during the gestational period and lactation on the blood pressure and renal system of adult offspring. Objectives: 1) To evaluate in the offspring of rats submitted to fructose overload during pregnancy and lactation the changes in blood pressure and renal morphology and function. 2) Evaluate these same parameters in the offspring of rats submitted to fructose overload during pregnancy and lactation which continued to receive fructose after weaning. (AU)
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