Evaluation of tuberculosis dynamics transmission among incarcerated people using whole genome sequencing of Mycobacterium tuberculosis.

• Grant number: 18/07341-1
• Support Opportunities: Regular Research Grants
• Duration: October 01, 2018 - September 30, 2020
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Valdes Roberto Bollela
• Grantee: Valdes Roberto Bollela
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated researchers: Aline Aparecida Monroe ; Juliana Failde Gallo ; Rosangela Siqueira de Oliveira ; Wilson Araújo da Silva Junior

Abstract

Brazil is one of 30 countries that concentrates approximately 87% of tuberculosis (TB) cases in the world. Despite the improvements in TB indicators, there is still a significant increase in the number of drug-resistant TB cases and TB in some specific groups like those with immune suppression, diabetes, TB contacts and incarcerated people. The prisoner´s environment brings various factors that favor TB transmission and that increases the likelihood of infection and development of disease and drug-resistant-TB (DR-TB) among detents and those who work in prisons. TB incidence in incarcerated people is 28 times greater than that of mainstream population in Brazil, suggesting a higher risk of disease propagation among these. The use of molecular techniques and molecular epidemiology to understand the susceptibility profile and the dynamics of transmission among incarcerated people might be very helpful to identify and prevent outbreaks. The objective of this study is to characterize the dynamics of transmission of M. tuberculosis from TB resistant TB people who made his diagnosis while they were in jail. This is a descriptive study with M. tuberculosis isolates as soon as they were imprisoned in one of the prisons in the Northeast and Northwest regions of the State of São Paulo, from January 2016 till December 2018. In all recovered isolates, a phenotypic and molecular evaluation of the isolates will be carried out, as well as the genomic and analytical sequencing of bioinformatics. The clinical and historical data of the incarcerated will be analyzed through two systems of notification SITE-TB and TB-WEB of the National Program of Tuberculosis Control, besides the information obtained by the Secretary of Administration Penitentiary (SAP) of the State of São Paulo. This project has already been submitted to the Hospital das Clínicas at School of Medicine of Ribeirão Preto IRB. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NAMBURETE, EVANGELINA INACIO; DIPPENAAR, ANZAAN; CONCEICAO, EMILYN COSTA; FELICIANO, CINARA; DO NASCIMENTO, MARGARIDA MARIA PASSERI; PERONNI, KAMILA CHAGAS; SILVA JR, WILSON ARAUJO; FERRO, JOSEFO JOAO; HARRISON, LEE H.; WARREN, ROBIN MARK; et al. Phylogenomic assessment of drug-resistant Mycobacterium tuberculosis strains from Beira, Mozambique. TUBERCULOSIS, v. 121, MAR 2020. (15/13333-3, 18/07341-1)

LÍVIA MARIA PALA ANSELMO; JULIANA FAILDE GALLO; JULIANA MAIRA WATANABE PINHATA; KAMILA CHAGAS PERONNI; WILSON ARAÚJO DA SILVA JUNIOR; PATRICIA DE CÁSSIA RUY; EMILYN COSTA CONCEIÇÃO; ANZAAN DIPPENAAR; ROBIN MARK WARREN; ALINE APARECIDA MONROE; et al. New insights on tuberculosis transmission dynamics and drug susceptibility profiles among the prison population in Southern Brazil based on whole-genome sequencing. Revista da Sociedade Brasileira de Medicina Tropical, v. 56, 2023-02-20. (18/07341-1)