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Pharmacochemistry and photochemistry of corannulenes and natural antioxidants

Grant number: 18/08333-2
Support type:Regular Research Grants
Duration: September 01, 2018 - August 31, 2020
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Cooperation agreement: Tianjin University
Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
Principal Investigator:Mauricio da Silva Baptista
Grantee:Mauricio da Silva Baptista
Principal investigator abroad: Jay Steven Siegel
Institution abroad: Tianjin University (TJU), China
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:13/07937-8 - Redoxome - Redox Processes in Biomedicine, AP.CEPID


The present project will contribute to the knowledge of singlet oxygen formation sensitized by non-planar aromatic hydrocarbons and to the knowledge of pathways for metabolic degradation of photodynamic therapy (PDT) sensitizers and to the metabolic degradation of natural plant pigments. Both themes are related to fundamental studies of chemical or photochemical reactivity, but at the same time have potential biochemical and pharmacochemical implications. This interdisciplinary project brings together nine research groups with clearly complementary areas of expertise, whose joint dedication to this project will serve to consolidate the strategic academic and research collaboration between the University of Sao Paulo and the Tianjin University. (AU)