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Uncovering the PDT mechanism of new organic/inorganic hybrid photosensitizers

Grant number: 17/50412-4
Support type:Regular Research Grants
Duration: October 01, 2018 - September 30, 2020
Field of knowledge:Biological Sciences - Biophysics
Cooperation agreement: Leiden University
Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
Principal Investigator:Mauricio da Silva Baptista
Grantee:Mauricio da Silva Baptista
Principal investigator abroad: Sylvestre Bonnet
Institution abroad: Universiteit Leiden, Netherlands
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:13/07937-8 - Redoxome - Redox Processes in Biomedicine, AP.CEPID

Abstract

The use of light as a therapeutic modality has recently become an attractive mode of therapy due to the development of efficient and affordable light sources, together with its low invasiveness and low systemic toxicity. Consequently, photo-activated drugs (photosensitizers-PS), are playing key roles in the present clinical portfolio (in a modality called Photodynamic Therapy-PDT). Although the majority of PDT drugs available are based in organic compounds the amount of research dedicated to the development of photosensitizers based in inorganic/organic hybrids has increased recently. Several groups have shown improved efficiency, probably because of a multimode of action but the mechanistic works are still missing. The major aim of this proposal is to bring together the expertise from the Bonnet and Baptista groups for the design and development of new ruthenium-based photosensitizers tailored for the maximizing photosensitizer efficiency by modulating type I and type II mechanisms. The specific aims of this proposal are: i) synthesis and characterization of new inorganic/organic hybrid complexes; ii) Quantification of the ability of the complexes to undergo photoinduced sensitization of singlet oxygen and type I reaction in solution and membrane mimic; iii)Testing in cell culture (monolayer and 3D). (AU)

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