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Essential oil amended with metal nanoparticles functionalized with nitric oxide as a strategy to control of plant pathogens in the agriculture

Grant number: 18/08194-2
Support type:Regular Research Grants
Duration: December 01, 2018 - May 31, 2022
Field of knowledge:Interdisciplinary Subjects
Cooperation agreement: Comisión Nacional de Investigación Científica y Tecnológica (CONICYT)
Principal Investigator:Amedea Barozzi Seabra
Grantee:Amedea Barozzi Seabra
Principal investigator abroad: Olga Margarita Rubilar Araneda
Institution abroad: Universidad de La Frontera (UFRO), Chile
Home Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
Assoc. researchers:Bruno Lemos Batista ; Nelson Eduardo Duran Caballero

Abstract

Nanotechnology has the potential to make an impact in agriculture through nanoencapsulation of pesticides, herbicides and agrochemicals resulting in precise dosage to the plants. Silver and copper nanoparticles are known to have potent antimicrobial activity against several pathogens. Although these nanoparticles have been greatly explored in biomedical applications, their uses in plant defense are still in the infancy. Metal nanoparticles can be synthesized by chemical, physical and biogenic routes. Biogenic synthesis of metal nanoparticles is considered cost effective and environmentally friend approach. In this direction, this project proposes the biogenic synthesis of silver and copper nanoparticles by using fungi, specifically white rot fungi, in a green approach. The surface of the biogenically synthesized silver or copper nanoparticles will be functionalized with nitric oxide (NO) donors, since NO is a potent antimicrobial agent. NO is an endogenous found molecule that controls several physiological processes in mammals and in plants, including plant defense against pathogens. Although NO-releasing metallic nanoparticles have been explored in biomedical fields, their uses in agriculture have not been explored. The obtained NO-releasing metal nanoparticles will be incorporated into essential oils, which have antimicrobial activity. Therefore, the goal of this project is to use a green approach to synthesize metal nanoparticles, coat their surface with the antimicrobial molecule NO, and incorporate the final nanoparticles in essential oils in agriculture applications for pest control. It is expected to reduce the pesticide applications and to increase the food security. (AU)

Scientific publications (21)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PIERETTI, JOANA C.; RUBILAR, OLGA; WELLER, RICHARD B.; TORTELLA, GONZALO R.; SEABRA, AMEDEA B. Nitric oxide (NO) and nanoparticles - Potential small tools for the war against COVID-19 and other human coronavirus infections. VIRUS RESEARCH, v. 291, JAN 2 2021. Web of Science Citations: 0.
PELEGRINO, MILENA T.; PIERETTI, JOANA C.; NAKAZATO, GERSON; GONCALVES, MARCELLY CHUE; MOREIRA, JOSE CARLOS; SEABRA, AMEDEA B. Chitosan chemically modified to deliver nitric oxide with high antibacterial activity. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 106, p. 24-34, JAN 1 2021. Web of Science Citations: 0.
KOHATSU, MARCIO YUKIHIRO; PELEGRINO, MILENA TREVISAN; MONTEIRO, LUCILENA REBELO; FREIRE, BRUNA MOREIRA; PEREIRA, RODRIGO MENDES; FINCHEIRA, PAOLA; RUBILAR, OLGA; TORTELLA, GONZALO; BATISTA, BRUNO LEMOS; DE JESUS, TATIANE ARAUJO; SEABRA, AMEDEA BAROZZI; LANGE, CAMILA NEVES. Comparison of foliar spray and soil irrigation of biogenic CuO nanoparticles (NPs) on elemental uptake and accumulation in lettuce. Environmental Science and Pollution Research, JAN 2021. Web of Science Citations: 0.
TORTELLA, GONZALO R.; RUBILAR, OLGA; DIEZ, MARIA CRISTINA; PADRAO, JORGE; ZILLE, ANDREA; PIERETTI, JOANA C.; SEABRA, AMEDEA B. Advanced Material Against Human (Including Covid-19) and Plant Viruses: Nanoparticles As a Feasible Strategy. GLOBAL CHALLENGES, DEC 2020. Web of Science Citations: 0.
PIERETTI, JOANA CLAUDIO; CRUZ JUNHO, CAROLINA VICTORIA; CARNEIRO-RAMOS, MARCELA SORELLI; SEABRA, AMEDEA BAROZZI. H2S- and NO-releasing gasotransmitter platform: A crosstalk signaling pathway in the treatment of acute kidney injury. PHARMACOLOGICAL RESEARCH, v. 161, NOV 2020. Web of Science Citations: 0.
CAIO-SILVA, WELLINGTON; DA SILVA DIAS, DANIELLE; JUNHO, CAROLINA VICTORIA CRUZ; PANICO, KARINE; NERES-SANTOS, RAQUEL SILVA; PELEGRINO, MILENA TREVISAN; PIERETTI, JOANA CLAUDIO; SEABRA, AMEDEA BAROZZI; DE ANGELIS, KATIA; CARNEIRO-RAMOS, MARCELA SORELLI. Characterization of the Oxidative Stress in Renal Ischemia/Reperfusion-Induced Cardiorenal Syndrome Type 3. BIOMED RESEARCH INTERNATIONAL, v. 2020, OCT 9 2020. Web of Science Citations: 0.
URZEDO, ALESSANDRO L.; GONCALVES, MARCELLY C.; NASCIMENTO, MONICA H. M.; LOMBELLO, CHRISTIANE B.; NAKAZATO, GERSON; SEABRA, AMEDEA B. Multifunctional alginate nanoparticles containing nitric oxide donor and silver nanoparticles for biomedical applications. Materials Science & Engineering C-Materials for Biological Applications, v. 112, JUL 2020. Web of Science Citations: 0.
PISSOLATO, MARIA DOLORES; SILVEIRA, NEIDIQUELE MARIA; PRATAVIERA, PAULA JOYCE CARRENHO; MACHADO, EDUARDO CARUSO; SEABRA, AMEDEA BAROZZI; PELEGRINO, MILENA TREVISAN; SODEK, LADASLAV; RIBEIRO, RAFAEL V. Enhanced Nitric Oxide Synthesis Through Nitrate Supply Improves Drought Tolerance of Sugarcane Plants. FRONTIERS IN PLANT SCIENCE, v. 11, JUN 30 2020. Web of Science Citations: 0.
PIERETTI, JOANA C.; PELEGRINO, MILENA T.; NASCIMENTO, MONICA H. M.; TORTELLA, GONZALO R.; RUBILAR, OLGA; SEABRA, AMEDEA B. Small molecules for great solutions: Can nitric oxide-releasing nanomaterials overcome drug resistance in chemotherapy?. Biochemical Pharmacology, v. 176, n. SI JUN 2020. Web of Science Citations: 0.
TORTELLA, G. R.; RUBILAR, O.; DURAN, N.; DIEZ, M. C.; MARTINEZ, M.; PARADA, J.; SEABRA, A. B. Silver nanoparticles: Toxicity in model organisms as an overview of its hazard for human health and the environment. JOURNAL OF HAZARDOUS MATERIALS, v. 390, MAY 15 2020. Web of Science Citations: 4.
RODRIGUES, MARCELA CHARANTOLA; ROLIM, WALLACE ROSADO; VIANA, MARINA MARIANTE; SOUZA, THAIS RODRIGUES; GONCALVES, FLAVIA; TANAKA, CAIO JUNJI; BUENO-SILVA, BRUNO; SEABRA, AMEDEA BAROZZI. Biogenic synthesis and antimicrobial activity of silica-coated silver nanoparticles for esthetic dental applications. Journal of Dentistry, v. 96, MAY 2020. Web of Science Citations: 0.
URZEDO, ALESSANDRO L.; GONCALVES, MARCELLY C.; NASCIMENTO, MONICA H. M.; LOMBELLO, CHRISTIANE B.; NAKAZATO, GERSON; SEABRA, AMEDEA B. Cytotoxicity and Antibacterial Activity of Alginate Hydrogel Containing Nitric Oxide Donor and Silver Nanoparticles for Topical Applications. ACS BIOMATERIALS SCIENCE & ENGINEERING, v. 6, n. 4, p. 2117-2134, APR 2020. Web of Science Citations: 5.
PELEGRINO, MILENA TREVISAN; KOHATSU, MARCIO YUKIHIRO; SEABRA, AMEDEA BAROZZI; MONTEIRO, LUCILENA REBELO; GOMES, DIEGO GENUARIO; OLIVEIRA, HALLEY CAIXETA; ROLIM, WALLACE ROSADO; DE JESUS, TATIANE ARAUJO; BATISTA, BRUNO LEMOS; LANGE, CAMILA NEVES. Effects of copper oxide nanoparticles on growth of lettuce (Lactuca sativa L.) seedlings and possible implications of nitric oxide in their antioxidative defense. ENVIRONMENTAL MONITORING AND ASSESSMENT, v. 192, n. 4 MAR 12 2020. Web of Science Citations: 0.
LUZO, ANGELA C. M.; FAVARO, WAGNER J.; SEABRA, AMEDEA B.; DURAN, NELSON. What is the potential use of platelet-rich-plasma (PRP) in cancer treatment? A mini review. HELIYON, v. 6, n. 3 MAR 2020. Web of Science Citations: 0.
PIERETTI, JOANA C.; ROLIM, WALLACE R.; FERREIRA, FABIO F.; LOMBELLO, CHRISTIANE B.; NASCIMENTO, MONICA H. M.; SEABRA, AMEDEA B. Synthesis, Characterization, and Cytotoxicity of Fe3O4@Ag Hybrid Nanoparticles: Promising Applications in Cancer Treatment. JOURNAL OF CLUSTER SCIENCE, v. 31, n. 2, p. 535-547, MAR 2020. Web of Science Citations: 0.
PELEGRINO, MILENA T.; WELLER, RICHARD B.; PAGANOTTI, ANDRE; SEABRA, AMEDEA B. Delivering nitric oxide into human skin from encapsulated S-nitrosoglutathione under UV light: An in vitro and ex vivo study. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 94, p. 108-113, JAN 1 2020. Web of Science Citations: 0.
DURAN, NELSON; FAVARO, WAGNER J.; SCABRA, AMCDCA B. What do we Really Know about Nanotoxicology of Silver Nanoparticles In vivo? New Aspects, Possible Mechanisms, and Perspectives. CURRENT NANOSCIENCE, v. 16, n. 3, p. 292-320, 2020. Web of Science Citations: 0.
NASCIMENTO, MONICA H. M.; PELEGRINO, MILENA T.; PIERETTI, JOANA C.; SEABRAL, AMEDEA B. How can nitric oxide help osteogenesis?. AIMS MOLECULAR SCIENCE, v. 7, n. 1, p. 29-48, 2020. Web of Science Citations: 0.
LOPES-OLIVEIRA, PATRICIA JULIANA; GOMES, DIEGO GENUARIO; PELEGRINO, MILENA TREVISAN; BIANCHINI, EDMILSON; PIMENTA, JOSE ANTONIO; STOLF-MOREIRA, RENATA; SEABRA, AMEDEA BAROZZI; OLIVEIRA, HALLEY CAIXETA. Effects of nitric oxide-releasing nanoparticles on neotropical tree seedlings submitted to acclimation under full sun in the nursery. SCIENTIFIC REPORTS, v. 9, NOV 22 2019. Web of Science Citations: 0.
GALLARDO-BENAVENTE, CARLA; CARRION, ORNELLA; TODD, JONATHAN D.; PIERETTI, JOANA C.; SEABRA, AMEDEA B.; DURAN, NELSON; RUBILAR, OLGA; PEREZ-DONOSO, JOSE M.; QUIROZ, ANDRES. Biosynthesis of CdS Quantum Dots Mediated by Volatile Sulfur Compounds Released by Antarctic Pseudomonas fragi. FRONTIERS IN MICROBIOLOGY, v. 10, AUG 13 2019. Web of Science Citations: 0.
SILVEIRA, NEIDIQUELE M.; SEABRA, AMEDEA B.; MARCOS, FERNANDA C. C.; PELEGRINO, MILENA T.; MACHADO, EDUARDO C.; RIBEIRO, RAFAEL V. Encapsulation of S-nitrosoglutathione into chitosan nanoparticles improves drought tolerance of sugarcane plants. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 84, p. 38-44, MAR 1 2019. Web of Science Citations: 3.

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