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The prognostic value and biological role of overexpressed proteins in oral squamous cell carcinoma identified by mass spectrometry-based proteomic

Grant number: 18/16077-6
Support type:Regular Research Grants
Duration: December 01, 2018 - May 31, 2021
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Ricardo Della Coletta
Grantee:Ricardo Della Coletta
Home Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil

Abstract

Despite the improvement in the diagnosis and treatment of patients with oral squamous cell carcinoma (OSCC), the 5-year survival rate remains around 50-60%, without significant changes in the last decades. The treatment decision and patient's prognosis relies on clinical parameters (TNM system) and histopathological features, tools that have not been shown to be widely effective. In that sense, the identification, validation, and clinical implementation of new markers that would help in the treatment selection, and occasionally prove to be new therapeutic targets that also aid the prognosis prediction, is needed and urgent. The aim of this study is to select proteins that are promising markers to be used in patients with OSCC. For that, an initial selection was based on proteins lists originated in previous studies from our group, which resulted in the selection of 7 potential targets: tumor-associated calcium signal transducer 2 (TACSTD2), copine-1 (CPNE1), serpin family H member 1 (SERPINH1), stress-induced-phosphoprotein 1 (STIP1), proteasome subunit alpha type-6 (PSMA6), septin 9 (SEPT9) and stanniocalcin 2 (STC2). The selected proteins will be firstly validated by immunohistochemistry, and 3 of the most promising will be chosen for the further functional assays based on the malignant phenotypes of cancer. With this study, we expect to identify proteins that show prognostic value on OSCC and an important role in the tumor progression, which could reflect on improvement in the disease treatment, in the future. It is important to highlight that, until today, none of the OSCC markers described in the literature are used in the clinic because of the lack of strong evidence. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOURADO, MAURICIO ROCHA; MACHADO, RENATO ASSIS; PARANAIBA, LIVIA MARIS RIBEIRO; GONZALEZ-ARRIAGADA, WILFREDO ALEJANDRO; DA SILVA, SABRINA DANIELA; SAWAZAKI-CALONE, IRIS; GRANER, EDGARD; SALO, TUULA; COLETTA, RICARDO D. Trophoblast cell surface antigen 2 expression predicts outcome in oral squamous cell carcinomas. ORAL DISEASES, MAR 2021. Web of Science Citations: 0.
DOMINGUETI, CATHERINE BUENO; MIWA, KAREN YUMIE MENDONCA; DOURADO, MAURICIO ROCHA; SAWAZAKI-CALONE, IRIS; SALO, TUULA A.; PARANAIBA, LIVIA MARIS RIBEIRO; COLETTA, RICARDO D. Prognostication for oral carcinomas based on two histological scoring systems (BD and iBD models). ORAL DISEASES, v. 27, n. 4 SEP 2020. Web of Science Citations: 0.
DOURADO, MAURICIO R.; MIWA, KAREN Y. M.; HAMADA, GUILHERME B.; PARANAIBA, LIVIA M. R.; SAWAZAKI-CALONE, IRIS; DOMINGUETI, CATHERINE B.; DE OLIVEIRA, CARINE ERVOLINO; FURLAN, EMYLLE C. B.; LONGO, BRUNA C.; ALMANGUSH, ALHADI; SALO, TUULA; COLETTA, RICARDO D. Prognostication for oral squamous cell carcinoma patients based on the tumour-stroma ratio and tumour budding. Histopathology, v. 76, n. 6 MAY 2020. Web of Science Citations: 0.

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