Research Grants 18/16077-6 - Biomarcadores, Sobrevida - BV FAPESP
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The prognostic value and biological role of overexpressed proteins in oral squamous cell carcinoma identified by mass spectrometry-based proteomic

Grant number: 18/16077-6
Support Opportunities:Regular Research Grants
Start date: December 01, 2018
End date: November 30, 2021
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Ricardo Della Coletta
Grantee:Ricardo Della Coletta
Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil

Abstract

Despite the improvement in the diagnosis and treatment of patients with oral squamous cell carcinoma (OSCC), the 5-year survival rate remains around 50-60%, without significant changes in the last decades. The treatment decision and patient's prognosis relies on clinical parameters (TNM system) and histopathological features, tools that have not been shown to be widely effective. In that sense, the identification, validation, and clinical implementation of new markers that would help in the treatment selection, and occasionally prove to be new therapeutic targets that also aid the prognosis prediction, is needed and urgent. The aim of this study is to select proteins that are promising markers to be used in patients with OSCC. For that, an initial selection was based on proteins lists originated in previous studies from our group, which resulted in the selection of 7 potential targets: tumor-associated calcium signal transducer 2 (TACSTD2), copine-1 (CPNE1), serpin family H member 1 (SERPINH1), stress-induced-phosphoprotein 1 (STIP1), proteasome subunit alpha type-6 (PSMA6), septin 9 (SEPT9) and stanniocalcin 2 (STC2). The selected proteins will be firstly validated by immunohistochemistry, and 3 of the most promising will be chosen for the further functional assays based on the malignant phenotypes of cancer. With this study, we expect to identify proteins that show prognostic value on OSCC and an important role in the tumor progression, which could reflect on improvement in the disease treatment, in the future. It is important to highlight that, until today, none of the OSCC markers described in the literature are used in the clinic because of the lack of strong evidence. (AU)

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Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA COSTA, BRUNO CESAR; DOURADO, MAURICIO ROCHA; DE MORAES, EVERTON FREITAS; PANINI, LUANA MARI; ELSERAGY, AMR; TEO, FABIO HAACH; GUIMARAES, GUSTAVO NARVAES; MACHADO, RENATO ASSIS; RISTELI, MAIJA; GURGEL ROCHA, CLARISSA ARAUJO; et al. Overexpression of heat-shock protein 47 impacts survival of patients with oral squamous cell carcinoma. JOURNAL OF ORAL PATHOLOGY & MEDICINE, v. 52, n. 7, p. 9-pg., . (21/08943-8, 22/01123-8, 21/13595-9, 22/00994-5, 18/16077-6)
DOMINGUETI, CATHERINE BUENO; MIWA, KAREN YUMIE MENDONCA; DOURADO, MAURICIO ROCHA; SAWAZAKI-CALONE, IRIS; SALO, TUULA A.; PARANAIBA, LIVIA MARIS RIBEIRO; COLETTA, RICARDO D.. Prognostication for oral carcinomas based on two histological scoring systems (BD and iBD models). ORAL DISEASES, v. 27, n. 4, . (17/26764-8, 18/16077-6, 18/16754-8)
DOURADO, MAURICIO R.; MIWA, KAREN Y. M.; HAMADA, GUILHERME B.; PARANAIBA, LIVIA M. R.; SAWAZAKI-CALONE, IRIS; DOMINGUETI, CATHERINE B.; DE OLIVEIRA, CARINE ERVOLINO; FURLAN, EMYLLE C. B.; LONGO, BRUNA C.; ALMANGUSH, ALHADI; et al. Prognostication for oral squamous cell carcinoma patients based on the tumour-stroma ratio and tumour budding. Histopathology, v. 76, n. 6, . (17/26764-8, 18/16077-6, 18/16754-8, 18/17689-5)
DOLENS, EDER DA SILVA; DOURADO, MAURICIO ROCHA; ALMANGUSH, ALHADI; SALO, TUULA A.; GURGEL ROCHA, CLARISSA ARAUJO; DA SILVA, SABRINA DANIELA; BRENNAN, PETER A.; COLETTA, RICARDO D.. The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis. FRONTIERS IN ONCOLOGY, v. 11, . (18/16077-6, 17/26764-8)
DOURADO, MAURICIO ROCHA; MACHADO, RENATO ASSIS; PARANAIBA, LIVIA MARIS RIBEIRO; GONZALEZ-ARRIAGADA, WILFREDO ALEJANDRO; DA SILVA, SABRINA DANIELA; SAWAZAKI-CALONE, IRIS; GRANER, EDGARD; SALO, TUULA; COLETTA, RICARDO D.. Trophoblast cell surface antigen 2 expression predicts outcome in oral squamous cell carcinomas. ORAL DISEASES, v. 28, n. 4, p. 9-pg., . (17/26764-8, 18/16077-6)
DA DOLENS, EDER SILVA; DE MORAIS, EVERTON FREITAS; RIBEIRO PARANAIBA, LIVIA MARIS; CARRINHO AYROZA RANGEL, ANA LUCIA; ALMANGUSH, ALHADI; SALO, TUULA; BRENNAN, PETER A.; COLETTA, RICARDO D.. Prognostic significance of the neural invasion in oral squamous cell carcinoma. JOURNAL OF ORAL PATHOLOGY & MEDICINE, v. 52, n. 6, p. 7-pg., . (22/00994-5, 18/16077-6)
DOURADO, MAURICIO ROCHA; MACHADO, RENATO ASSIS; PARANAIBA, LIVIA MARIS RIBEIRO; GONZALEZ-ARRIAGADA, WILFREDO ALEJANDRO; DA SILVA, SABRINA DANIELA; SAWAZAKI-CALONE, IRIS; GRANER, EDGARD; SALO, TUULA; COLETTA, RICARDO D.. Trophoblast cell surface antigen 2 expression predicts outcome in oral squamous cell carcinomas. ORAL DISEASES, . (18/16077-6, 17/26764-8)
DOURADO, MAURICIO ROCHA; ELSERAGY, AMR; DA COSTA, BRUNO CESAR; TEO, FABIO HAACH; GUIMARAES, GUSTAVO NARVAES; MACHADO, RENATO ASSIS; RISTELI, MAIJA; WAHBI, WAFA; GURGEL ROCHA, CLARISSA ARAUJO; RIBEIRO PARANAIBA, LIVIA MARIS; et al. Stress induced phosphoprotein 1 overexpression controls proliferation, migration and invasion and is associated with poor survival in oral squamous cell carcinoma. FRONTIERS IN ONCOLOGY, v. 12, p. 15-pg., . (18/16077-6, 21/13595-9, 21/08943-8)
DOMINGUES SILVA, GABRIELA VIVILI; DOLENS, EDER DA SILVA; RIBEIRO PARANAIBA, LIVIA MARIS; CARRINHO AYROZA, ANA LUCIA; GURGEL ROCHA, CLARISSA ARAUJO; ALMANGUSH, ALHADI; SALO, TUULA; BRENNAN, PETER A.; COLETTA, RICARDO D.. Exploring the combination of tumor-stroma ratio, tumor-infiltrating lymphocytes, and tumor budding with WHO histopathological grading on early-stage oral squamous cell carcinoma prognosis. JOURNAL OF ORAL PATHOLOGY & MEDICINE, v. N/A, p. 8-pg., . (21/13595-9, 18/16077-6)

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