Lifestyle, biochemical and genetic markers as cardiometabolic risk factors: Health Survey in São Paulo City

• Grant number: 17/05125-7
• Support type: Research Projects - Thematic Grants
• Duration: February 01, 2019 - January 31, 2024
• Field of knowledge: Health Sciences - Nutrition - Nutritional Analysis of Population
• Principal researcher: Regina Mara Fisberg
• Grantee: Regina Mara Fisberg
• Home Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Pesquisadores principais: Flávia Mori Sarti ; Marcelo Macedo Rogero
• Assoc. researchers: Adèle Helena Ribeiro ; Alex Antonio Florindo ; Andressa Cerqueira ; Bárbara Santarosa Emo Peters ; Billie Giles-Corti ; Chester Luiz Galvão Cesar ; Cristiane Hermes Sales ; Elizabeth Aparecida Ferraz da Silva Torres ; Ioná Zalcman Zimberg ; Josiemer Mattei ; Júlia Maria Pavan Soler ; Lígia Araújo Martini ; Ligia Vizeu Barrozo ; Maria Cecilia Goi Porto Alves ; Marilisa Berti de Azevedo Barros ; Michelle Alessandra de Castro ; Moisés Goldbaum ; Nágila Raquel Teixeira Damasceno ; Philip Charles Calder ; Regina Célia Mingroni Netto ; Sandra Maria Lima Ribeiro
• Associated scholarship(s): 22/03420-0 - Learning causal graphical models for obesity and other nutrition-related disorders, BP.IC; 20/15899-2 - Association between dyslipidemias and health costs at population level: Polygenic risk scores and modeling through computational microsimulation., BP.DR; 21/05327-4 - Analysis of factors associated with utilization and costs of health care in the context of Andersen's model: population-based study in the municipality of Sao Paulo, 2003-2015, BP.MS; + associated scholarships 20/06110-6 - Grain foods with d10:1 carbohydrate-to-fiber ratio in the population of São Paulo: analysis of effects of changes in diet on cardiometabolic risk factors, BP.PD; 20/07749-0 - Diet quality and genetic factors associated with Hypertension in residents of the city of São Paulo, BP.DR; 20/09451-9 - Fat consumption and cardiometabolic risk in residents of the city of São Paulo: dietary intake and cardioprotective potential considering polymorphisms in the FADS1 and FADS2 genes, BP.DR; 20/03104-5 - Plasma microRNA expression and its relationship with inflammatory biomarkers, nutritional status and dietary pattern in elderly people participating in a population-based study (ISA capital), BP.DR; 19/22934-1 - Association between circulating microRNA, cardiometabolic biomarkers and diet in adult individuals participants of a population-based study - ISA-Capital, BP.DR; 19/23985-9 - Investigation of molecular bases of multifactorial chronic diseases in the population of São Paulo by GWAS, BP.PD; 19/05685-8 - Iron and cardiometabolic risk factors in individuals living in the city of São Paulo: investigating the associations of the genetic susceptibility to type 2 diabetes, obesity and cardiovascular diseases, BP.PD - associated scholarships

Abstract

In view of the expressive prevalence of non-communicable chronic diseases (NCD), such as cardiovascular diseases, and negative repercussions on health and economy, strategies that investigate cardiometabolic risk factors are crucial for prevention and control of NCD. In this context, this population-based cross-sectional study aims to evaluate lifestyle-related modifiable factors in residents of the city of São Paulo, as well as its association with biochemical and genetic markers related to cardiometabolic risk factors. For this purpose, socio-demographic, economic and lifestyle data were collected in a structured questionnaire from individuals of both sexes, aged 12 years and older (n = 901). During the second visit, anthropometric evaluation, blood pressure measurement and blood collection were performed, and the adults and older adults were invited to perform bone densitometry and estimate energy expenditure by doubly labeled water. Blood was collected for determination of micronutrient concentration, glycaemia, lipid profile, inflammation biomarkers and single nucleotide polymorphisms. Food consumption was assessed by two 24-hour recalls. As NCD present multifactorial etiology, an approach that considers cardiometabolic risk markers (inflammation, lipoproteins, microRNA, intestinal permeability, DNA, body weight), risk behaviors (diet, physical activity, sleep, smoking, alcohol consumption) and also determinants of these behaviors (physical and social environment) can provide answers that allow effective interventions in public health. Therefore, this proposal brings a broad and, at the same time, profound approach to the complex relationships regarding NCD in the population. (AU)

Scientific publications

(11)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GARCEZ, MARCELA RICCIOPPO; DE CASTRO, MICHELLE ALESSANDRA; CESAR, CHESTER LUIS GALVAO; GOLDBAUM, MOISES; FISBERG, REGINA MARA. A chrononutrition perspective of diet quality and eating behaviors of Brazilian adolescents in associated with sleep duration. CHRONOBIOLOGY INTERNATIONAL, v. 38, n. 3, JAN 2021. (17/05125-7, 12/22113-9)

DE MELLO, ALINE VERONEZE; SARTI, FLAVIA MORI; FISBERG, REGINA MARA. How to Estimate Food Prices and Diet Costs in Population-Based Studies?. FRONTIERS IN NUTRITION, v. 8, OCT 22 2021. (09/15831-0, 17/05125-7)

FONTANELLI, MARIANE DE MELLO; ARROYO, ANGELA MARTINEZ; SALES, CRISTIANE HERMES; SEAL, CHRIS J.; FISBERG, REGINA MARA. Opportunities for diet quality improvement: the potential role of staple grain foods. PUBLIC HEALTH NUTRITION, v. 24, n. 18, p. 6145-6156, DEC 2021. (16/18742-1, 12/22113-9, 17/05125-7)

SALES, CRISTIANE HERMES; ROGERO, MARCELO MACEDO; SARTI, FLAVIA MORI; FISBERG, REGINA MARA. Prevalence and Factors Associated with Iron Deficiency and Anemia among Residents of Urban Areas of Sao Paulo, Brazil. NUTRIENTS, v. 13, n. 6, JUN 2021. (19/05685-8, 17/05125-7, 12/22113-9)

FELIX, PAULA VICTORIA; PEREIRA, JAQUELINE LOPES; LEME, ANA CAROLINA BARCO; DE CASTRO, MICHELLE ALESSANDRA; FISBERG, REGINA MARA. Nutritional breakfast quality and cardiometabolic risk factors: Health Survey of Sao Paulo, a population-based study. PUBLIC HEALTH NUTRITION, v. 24, n. 13, p. 4102-4112, SEP 2021. (17/05125-7)

LOPES, TATIANE DOS SANTOS; DE MELLO, ALINE VERONEZE; NOGUEIRA, LUANA ROMAO; LEME, ANA CAROLINA BARCO; FISBERG, REGINA MARA. Energia, nutrientes e fontes alimentares em lanches de adolescentes e jovens adultos. Revista Paulista de Pediatria, v. 40, 2022. (12/22113-9, 17/23115-9, 15/20852-7, 17/05125-7)

DE CASTRO, MICHELLE ALESSANDRA; GARCEZ, MARCELA RICCIOPPO; PEREIRA, JAQUELINE LOPES; FISBERG, REGINA MARA. Eating behaviours and dietary intake associations with self-reported sleep duration of free-living Brazilian adults. APPETITE, v. 137, p. 207-217, JUN 1 2019. (17/05125-7, 12/22113-9)

DE MELLO, ALINE VERONEZE; PEREIRA, JAQUELINE LOPES; LEME, ANA CAROLINA BARCO; GOLDBAUM, MOISES; GALVAO CESAR, CHESTER LUIZ; FISBERG, REGINA MARA. Social determinants, lifestyle and diet quality: a population-based study from the 2015 Health Survey of Sao Paulo, Brazil. PUBLIC HEALTH NUTRITION, v. 23, n. 10, p. 1766-1777, JUL 2020. (12/22113-9, 17/05125-7)

DE MENESES FUJII, TATIANE MIEKO; NORDE, MARINA MAINTINGUER; FISBERG, REGINA MARA; LOBO MARCHIONI, DIRCE MARIA; ORDOVAS, JOSE M.; ROGERO, MARCELO MACEDO. FADS1 and ELOVL2 polymorphisms reveal associations for differences in lipid metabolism in a cross-sectional population-based survey of Brazilian men and women. Nutrition Research, v. 78, p. 42-49, JUN 2020. (12/20401-7, 17/05125-7, 09/15831-0, 12/22113-9, 16/03803-5)

INAIAN PIGNATTI TEIXEIRA; JAQUELINE LOPES PEREIRA; JOÃO PAULO DOS ANJOS SOUZA BARBOSA; ALINE VERONEZE DE MELLO; BIANCA MITIE ONITA; REGINA MARA FISBERG; ALEX ANTONIO FLORINDO. Validade da massa corporal e da estatura autorreferidas: relações com sexo, idade, atividade física e fatores de risco cardiometabólicos. Revista Brasileira de Epidemiologia, v. 24, 2021-08-09. (17/05125-7, 20/01312-0, 17/17049-3, 12/22113-9)

BATISTA, LAIS DUARTE; GRANDE DE FRANCA, NATASHA APARECIDA; FONTANELLI, MARIANE DE MELLO; GRACIELA MARTINEZ-ARROYO, ANGELA; FISBERG, REGINA MARA. Misreporting of dietary energy intake obtained by 24 h recalls in older adults: a comparison of five previous methods using doubly labeled water. European Journal of Clinical Nutrition, AUG 2021. (18/01991-4, 17/05125-7)