The influence of G-protein-coupled receptors (GPCRs) on growth, morphogenesis and virulence of human pathogenic fungi

• Grant number: 18/10962-8
• Support Opportunities: Regular Research Grants
• Duration: February 01, 2019 - January 31, 2022
• Field of knowledge: Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
• Convênio/Acordo: Research Foundation - Flanders (FWO)
• Principal Investigator: Gustavo Henrique Goldman
• Grantee: Gustavo Henrique Goldman
• Principal researcher abroad: Van Dijck Patrick
• Institution abroad: University of Leuven, Leuven (KU Leuven), Belgium
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

This project aims to understand the mechanisms by which one GPCR can activate different downstream signaling pathways depending on the ligand that binds to the receptor. To investigate these mechanisms, we will work on two important human pathogenic fungi, Candida albicans and Aspergillus fumigatus. We are planning to investigate C. albicans Gpr1 and A. fumigatus GprJ and GprM and to understand which signal transduction and metabolic pathways are modulated by these GPCRs. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BASTOS, RAFAEL W.; ROSSATO, LUANA; GOLDMAN, GUSTAVO H.; SANTOS, DANIEL A.. ungicide effects on human fungal pathogens: Cross-resistance to medical drugs and beyon. PLOS PATHOGENS, v. 17, n. 12, DEC 2021. (16/07870-9, 18/10962-8, 17/19821-5)

DE CASTRO, PATRICIA ALVES; COLABARDINI, ANA CRISTINA; MORAES, MAISA; HORTA, MARIA AUGUSTA CRIVELENTE; KNOWLES, SONJA L.; RAJA, HUZEFA A.; OBERLIES, NICHOLAS H.; KOYAMA, YASUJI; OGAWA, MASAHIRO; GOMI, KATSUYA; et al. Regulation of gliotoxin biosynthesis and protection in Aspergillus species. PLOS GENETICS, v. 18, n. 1, p. 34-pg., 2022-01-01. (18/10962-8, 16/07870-9, 17/14159-2, 16/12948-7)

DA COSTA FILHO, AILTON PEREIRA; PEREIRA BRANCINI, GUILHERME THOMAZ; DE CASTRO, PATRICIA ALVES; VALERO, CLARA; FERREIRA FILHO, JAIRE ALVES; SILVA, LILIAN PEREIRA; ROCHA, MARINA CAMPOS; MALAVAZI, IRAN; DE MORAES PONTES, JOAO GUILHERME; FILL, TAICIA; et al. Aspergillus fumigatus G-Protein Coupled Receptors GprM and GprJ Are Important for the Regulation of the Cell Wall Integrity Pathway, Secondary Metabolite Production, and Virulence. MBIO, v. 11, n. 5, SEP-OCT 2020. (16/07870-9, 18/10962-8, 18/25217-6, 19/11929-7, 17/14159-2, 16/12948-7, 18/00715-3, 19/10727-1, 19/06359-7, 16/21392-2)