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The influence of G-protein-coupled receptors (GPCRs) on growth, morphogenesis and virulence of human pathogenic fungi

Grant number: 18/10962-8
Support type:Regular Research Grants
Duration: February 01, 2019 - January 31, 2022
Field of knowledge:Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
Cooperation agreement: Research Foundation - Flanders (FWO)
Principal researcher:Gustavo Henrique Goldman
Grantee:Gustavo Henrique Goldman
Principal researcher abroad: Van Dijck Patrick
Institution abroad: University of Leuven (KU Leuven), Belgium
Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

This project aims to understand the mechanisms by which one GPCR can activate different downstream signaling pathways depending on the ligand that binds to the receptor. To investigate these mechanisms, we will work on two important human pathogenic fungi, Candida albicans and Aspergillus fumigatus. We are planning to investigate C. albicans Gpr1 and A. fumigatus GprJ and GprM and to understand which signal transduction and metabolic pathways are modulated by these GPCRs. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA COSTA FILHO, AILTON PEREIRA; PEREIRA BRANCINI, GUILHERME THOMAZ; DE CASTRO, PATRICIA ALVES; VALERO, CLARA; FERREIRA FILHO, JAIRE ALVES; SILVA, LILIAN PEREIRA; ROCHA, MARINA CAMPOS; MALAVAZI, IRAN; DE MORAES PONTES, JOAO GUILHERME; FILL, TAICIA; SILVA, ROBERTO NASCIMENTO; ALMEIDA, FAUSTO; STEENWYK, JACOB L.; ROKAS, ANTONIS; DOS REIS, THAILA F.; RIES, LAURE N. A.; GOLDMAN, GUSTAVO H. Aspergillus fumigatus G-Protein Coupled Receptors GprM and GprJ Are Important for the Regulation of the Cell Wall Integrity Pathway, Secondary Metabolite Production, and Virulence. MBIO, v. 11, n. 5 SEP-OCT 2020. Web of Science Citations: 1.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.