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Sleep deprivation and possible heart changes in a model of Parkinson Disease induced by 6-hydroxidopamine in rats: understanding for sudden death in Parkinson's Disease (SUDPAR)

Grant number: 18/18568-7
Support type:Regular Research Grants
Duration: February 01, 2019 - January 31, 2021
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:Fulvio Alexandre Scorza
Grantee:Fulvio Alexandre Scorza
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Assoc. researchers:Fernando Luiz Affonso Fonseca ; Marcelo Ribeiro da Silva Briones ; Mariana Bocca Nejm Abou Haidar ; Monica Levy Andersen ; Renata Carmona e Ferreira

Abstract

Parkinson's disease (PD) is one of the most common age-related neurodegenerative disorders. Moreover, epidemiological studies have shown that people with PD are more likely to die prematurely than those without PD, and an important PD-related category of death is sudden unexpected death in Parkinson's disease (SUDPAR). Additionally, the cause of SUDPAR is still unknown; however, the most commonly suggested mechanisms are cardiac abnormalities found in PD patients. Ideally, this article intends to illustrate the phenomenon of SUDPAR. Despite the need for translational studies, some risk factors have been related to SUDPAR, such as age of onset, duration of PD, gender, motor severity, concomitant cardiac and pulmonary disease, drug treatment (polypharmacy), and sleep disorders. Sleep disorders are present in more than 50% of patients with PD and cause impairment in patients' health and quality of life. In this sense, the objective of this study will be to evaluate several cardiac parameters (physiological, inflammatory and molecular) through sleep deprivation in a 6-hydroxydopamine-induced PD model. (AU)