| Grant number: | 18/02543-5 |
| Support type: | Regular Research Grants |
| Duration: | January 01, 2019 - December 31, 2020 |
| Field of knowledge: | Health Sciences - Pharmacy - Toxicological Analysis |
| Principal researcher: | Gustavo Rafael Mazzaron Barcelos |
| Grantee: | Gustavo Rafael Mazzaron Barcelos |
| Home Institution: | Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil |
Abstract
Triclosan (TCS) is an antimicrobial agent widely used in personal hygiene products (PHP) and diethylhydroxyl (DEHP) is a phthalate group of chemical compounds derived from phthalic acid and is used in medical equipment and plastic products with chlorinated polyvinyls. As a result of their extensive use, these toxicants have been found in the environment and previous studies have demonstrated the relationship between their exposure and various toxic effects. However, there is scarcity in the literature of its toxic effects in mammals and especially in humans. In addition, no studies were carried out to evaluate the co-exposure of these toxicants in laboratory models. Thus, the aim of this work is to evaluate the cytotoxicity, genotoxicity, mutagenicity and expression profile of a panel of genes associated with metal metabolism, as well as genes related to the antioxidant status and DNA repair, in liver cell culture (HepG2) co-exposed to TCS and DEHP. Therefore, the project aims to increase the understanding of the mechanisms of toxicity involved in a co-exposure model, representing a much more real scenario than the evaluation per se of each toxicant. (AU)