ASSOCIATION BETWEEN SERUM AND FUNCTIONAL BIOMARKERS, AND IMAGE EXAMS IN DIASTOLIC AND COGNITIVE DYSFUNCTIONS

• Grant number: 18/19006-2
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2019
• End date: August 31, 2021
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Maria Claudia Costa Irigoyen
• Grantee: Maria Claudia Costa Irigoyen
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• City of the host institution: São Paulo
• Associated researchers: Fernanda Marciano Consolim-Colombo

Abstract

Diastolic dysfunction (DD) and cognitive dysfunction (DC) are asymptomatic alterações that precede severe conditions, as heart failure and dementia. Several risk factors contribute to DD and DC development, for instance, hypertension and aging. In order to prevent and treat these dysfunctions, and avoid worse outcomes, it is necessary to shed light on the knowledge about DD and DC pathophysiological process, and how they interact with each other. Additionally, fast, early and effective diagnostic methods for DD and Dc are lacking. In this context, our proposal is, in the first attempt, to evaluate echocardiographic and brain magnetic resonance in two models: a) an animal model (mice under transverse aortic coarctation), b) a human model (hypertensive patients), as both present DD and DC. Before the observed alterations, we will apply metabolomics to identify serum markers which are common to both dysfunctions, and we will correlate them with functional and image alterations. Therefore, we intend to validate these biomarkers as a method of early DD diagnostic. As the mechanisms of progression from the DD asymptomatic state to heart failure are not well known, and DD is strongly related to DC, success in this project will help not only in translational knowledge generation and diffusion, but will also disseminate the importance of giving attention to these early alterations (AU)

Scientific publications

(11)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NASCIMENTO-CARVALHO, BRUNO; DA SILVA, BRUNO DURANTE; DA SILVA, MAIKON BARBOSA; DOS-SANTOS, ADRIANO; RIBEIRO, THAYNA FABIANA; DA SILVA DIAS, DANIELLE; DE SOUZA, LEANDRO EZIQUIEL; DUTRA, MARINA RASCIO HENRIQUES; CATANOZI, SERGIO; CALDINI, ELIA G.; et al. Aerobic exercise attenuates dysautonomia, cardiac diastolic dysfunctions, and hemodynamic overload in female mice with atherosclerosis. SCIENTIFIC REPORTS, v. 14, n. 1, p. 12-pg., 2024-04-03. (18/19006-2)

PARADELA, REGINA SILVA; CABELLA, BRENNO; NUCCI, MARIANA PENTEADO; FERREIRA, NAOMI VIDAL; TORRES, LAURA ALO; MARTINO, LUIZA MENONI; CONSOLIM-COLOMBO, FERNANDA MARCIANO; BORTOLOTTO, LUIZ APARECIDO; DA COSTA, DANIELLE IRIGOYEN; IRIGOYEN, MARIA CLAUDIA. Computerized working memory training for hypertensive individuals with executive function impairment: a randomized clinical trial. FRONTIERS IN NEUROSCIENCE, v. 17, p. 12-pg., 2023-07-07. (18/19006-2)

DIAS MOREIRA, NATHALIA JUOCYS; DOS SANTOS, FERNANDO; MOREIRA, EDSON DIAS; FARAH, DANIELA; DE SOUZA, LEANDRO EZIQUIEL; DA SILVA, MAIKON BARBOSA; MORAES-SILVA, IVANA CINTHYA; LINCEVICIUS, GISELE SILVERIO; CALDINI, ELIA GARCIA; COSTA IRIGOYEN, MARIA CLAUDIA. Acute renal denervation normalizes aortic function and decreases blood pressure in spontaneously hypertensive rats. SCIENTIFIC REPORTS, v. 10, n. 1, DEC 11 2020. (18/19006-2)

ARAUJO, GUSTAVO S. M.; SILVA, THIAGO O. C.; GUERRA, GRAZIA M.; IZAIAS, JOAO E.; ROCHA, HELENA M. N.; FARIA, DIEGO; ROCHA, NATALIA G.; DALMAZO, ALINE LOPES; ARAUJO, AMANDA; MARCIANO CONSOLIM-COLOMBO, FERNANDA; et al. Effects of Postprandial Lipemia Combined With Disturbed Blood Flow on the Flow-Mediated Dilation, Oxidative Stress, and Endothelial Microvesicles in Healthy Subjects. FRONTIERS IN PHYSIOLOGY, v. 13, p. 11-pg., 2022-02-24. (18/19006-2, 17/25613-6, 14/11671-6)

PARADELA, REGINA SILVA; DIAS, PATRICIA DE OLIVEIRA; DETOGNI, ARIELE; SAKAKI, TAMIRYS AKEMY; INACIO, JOSE FRANCISCO SECORUN; PELLANDA, LUCIA CAMPOS; RODRIGUES, CLARISSA G.; IRIGOYEN, MARIA CLAUDIA; DA COSTA, DANIELLE IRIGOYEN. Cogmed cognitive training for working memory: a systematic review and meta-analysis. Neuroscience, v. 581, p. 9-pg., 2025-08-16. (18/19006-2)

DE ALMEIDA SILVA, AMANDA; JENSEN, LEONARDO; MARQUES, JULIANA ROMEU; NASCIMENTO-CARVALHO, BRUNO; DE SOUZA, LEANDRO EZIQUIEL; DA SILVA, MAIKON BARBOSA; MOREIRA, NATHALIA JUOCYS DIAS; VERAS, MARIANA MATERA; WAKED, DUNIA; SOUZA, FELIPE LIMA; et al. Novel model of cardiac hypertrophy with cardiorenal dysfunction. SCIENTIFIC REPORTS, v. 15, n. 1, p. 16-pg., 2025-07-19. (18/19006-2)

S.C.F. FREITAS; C. PAIXÃO DOS SANTOS; A. ARNOLD; F.F. STOYELL-CONTI; M.R.H. DUTRA; M. VERAS; M.C. IRIGOYEN; K. DE ANGELIS. A method to assess heart rate variability in neonate rats: validation in normotensive and hypertensive animals. Brazilian Journal of Medical and Biological Research, v. 53, n. 8, 2020-06-26. (18/19006-2, 18/17183-4)

CONTI, FILIPE FERNANDES; IRIGOYEN, MARIA-CLAUDIA; SARTORI, MICHELLE; RIBEIRO, AMANDA APARECIDA; DOS SANTOS, FERNANDO; MACHI, JACQUELINE FREIRE; TABOAS FIGUEROA, DIEGO MENDROT; RODRIGUES, BRUNO; DE ANGELIS, KATIA. Aerobic Training Is Better Than Resistance Training on Cardiac Function and Autonomic Modulation in Female ob/ob Mice. FRONTIERS IN PHYSIOLOGY, v. 10, DEC 5 2019. (18/17183-4, 10/17188-4, 18/19006-2, 15/11223-6, 11/15828-9)

DIAS, DANIELLE DA SILVA; MORAES-SILVA, IVANA C.; BERNARDES, NATHALIA; BRITO-MONZANI, JANAINA DE OLIVEIRA; STOYELL-CONTI, FILIPE FERNANDES; MACHI, JACQUELINE FREIRE; LLESUY, SUSANA; IRIGOYEN, MARIA-CLAUDIA; DE ANGELIS, KATIA. Exercise training initiated at old stage of lifespan attenuates aging-and ovariectomy-induced cardiac and renal oxidative stress: Role of baroreflex. Experimental Gerontology, v. 124, SEP 2019. (18/17183-4, 18/19006-2, 15/11223-6)

TORRES, LAURA ALO; PARADELA, REGINA SILVA; MARTINO, LUIZA MENONI; DA COSTA, DANIELLE IRIGOYEN; IRIGOYEN, MARIA CLAUDIA. Higher Perceived Stress as an Independent Predictor for Lower Use of Emotion-Focused Coping Strategies in Hypertensive Individuals. FRONTIERS IN PSYCHOLOGY, v. 13, p. 7-pg., 2022-05-24. (18/19006-2)

PARADELA, REGINA SILVA; FERREIRA, NAOMI VIDAL; NUCCI, MARIANA PENTEADO; CABELLA, BRENNO; MARTINO, LUIZA MENONI; TORRES, LAURA ALO; DA COSTA, DANIELLE IRIGOYEN; CONSOLIM-COLOMBO, FERNANDA MARCIANO; SUEMOTO, CLAUDIA KIMIE; IRIGOYEN, MARIA CLAUDIA. Relation of a Socioeconomic Index with Cognitive Function and Neuroimaging in Hypertensive Individuals. JOURNAL OF ALZHEIMER'S DISEASE, v. 82, n. 2, p. 815-826, 2021. (18/19006-2)