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UK-Brazil joint centre for arbovirus discovery, diagnosis, genomics and epidemiology (CADDE)

Grant number: 18/14389-0
Support type:Research Projects - Thematic Grants
Duration: April 01, 2019 - March 31, 2022
Field of knowledge:Health Sciences - Medicine
Cooperation agreement: MRC, UKRI ; Newton Fund, with FAPESP as a partner institution in Brazil
Principal Investigator:Ester Cerdeira Sabino
Grantee:Ester Cerdeira Sabino
Principal investigator abroad: Nuno Miguel Rodrigues Pascoal Faria
Institution abroad: University of Oxford, England
Home Institution: Instituto de Medicina Tropical de São Paulo (IMT). Universidade de São Paulo (USP). São Paulo, SP, Brazil
Co-Principal Investigators:Adriano Pinter dos Santos ; Anna Sara Shafferman Levin ; Maria Anice Mureb Sallum ; Renato Pereira de Souza ; Vivian Helena Iida Avelino da Silva
Assoc. researchers:Licia Natal Fernandes ; Marcelo Urbano Ferreira ; Maurício Lacerda Nogueira
Associated scholarship(s):19/07544-2 - Mosquito field collections and COI barcode identification using MinION tecnology, BP.TT

Abstract

Recently Brazil has been affected by unexpected arbovirus epidemics of Zika, Chikungunya, dengue and Yellow fever viruses. The huge economic burden of Zika (R$ 1 billion) and the widespread presence of mosquito vectors in Brazil highlights the need for accurate predictions of disease spread, particularly in large, densely populated regions. This UK-Brazil Partnership will enhance and expand an excellent existing collaboration, with the aim of anticipating and preventing future arbovirus epidemics in Brazil. Our research questions include: 1) What arboviruses circulate in human, mosquito and reservoir populations in Brazil? 2) Where and how do arboviruses persist during non-epidemic periods? 3) What are the implications of genetic diversity of circulating arboviruses? 4) What factors convert a novel introduction into human populations into an epidemic, and how best to respond? Active surveillance in vectors and reservoirs will be combined with seroprevalence surveys in blood donors to characterize arboviral dynamics, genomics, transmission and immunity. Novel portable genome sequencing protocols and real-time epidemiological analyses will be undertaken for relevant arboviruses. Unifying information from genomics and epidemiology will strengthen the evidence base for public health actions and strength the capacity of Brazilian health system in response to emerging arboviral diseases. (AU)

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