Purine and kinin receptors as targets of study and therapeutic interventions in neurological diseases

• Grant number: 18/07366-4
• Support Opportunities: Research Projects - Thematic Grants
• Start date: April 01, 2019
• End date: March 31, 2025
• Field of knowledge: Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
• Principal Investigator: Alexander Henning Ulrich
• Grantee: Alexander Henning Ulrich
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• City of the host institution: São Paulo
• Pesquisadores principais:(Últimos): Luiz Roberto Giorgetti de Britto
• Associated researchers: Beatriz de Oliveira Monteiro ; Claudiana Lameu ; Cristiane Otero Reis Salum ; João Bosco Pesquero ; Luiz Henrique Catalani ; Marimélia Aparecida Porcionatto ; Mayana Zatz ; Roberto De Pasquale ; Roberto Kopke Salinas ; Silvana Chiavegatto
• Associated scholarship(s): 24/22717-9 - Effect of the P2X7 receptor on cortical neurodevelopment of the autism model from maternal immune activation (MIA), BP.DR; 24/17387-0 - The role of P2X7 and P2Y12 purinergic receptors in the neurodevelopment of autism spectrum disorders and Alzheimer's Disease: Integration of brain organoid and mouse models., BP.PD; 24/17556-6 - Role of purinergic receptors in an animal model of hippocampal immaturity, BP.DD; + associated scholarships 24/17748-2 - Assessment of social behavior in a murine model of hippocampal immaturity, BP.IC; 24/04616-0 - Inhibition of the P2X7 purinergic receptor in microglia-mediated neuroinflammation in the in vivo model of Alzheimer's disease and its possible correlation with GSK3, BP.IC; 24/04690-6 - The effect of caffeine and purinergic signaling in three-dimensional models of Alzheimer's Disease using bioprinting, BP.PD; 23/09308-0 - In vitro evaluation of the modulation of purinergic receptors P2Y6, P2Y12, and P2X7 in a microglial cell line, BP.IC; 23/06673-9 - Role of purinergic receptors and huntingtin in gastrulation., BP.TT; 23/04077-0 - Study of the co-morbidity of Bipolar Disorder and Alzheimer's Disease using 3D cultures of decellularized brain matrices., BP.TT; 22/10950-5 - Selection and evaluation of proteins and fundamental mechanisms for the formation of long-term memory, BP.DD; 22/10616-8 - Assessment of spatial memory, cognition and learning in a murine model of hippocampal immaturity, BP.IC; 22/12888-5 - Role of the P2X7 purinergic receptor in microglia-mediated neurotoxicity in models of Alzheimer's disease and its possible correlation with the modulation of neurogenesis, BP.IC; 22/01304-2 - In vitro studies of the role of P2X4 receptors on inflammatory processes involved in Parkinsons Disease, BP.MS; 21/01478-8 - Molecular effects of pharmacological modulation of P2Y6 receptors in an in vitro model for the study of Alzheimer's Disease, BP.MS; 21/04769-3 - Purinergic signaling mediated by exosomes in the plasticity of the tumor microenvironment and chemoresistance of Neuroblastoma, BP.DD; 21/00060-0 - Role of P2Y14 receptor modulation in the hippocampal neuroinflammatory responses in in vitro and in vivo models of Alzheimer's Disease, BP.PD; 21/05279-0 - The role of purinergic receptors and Huntingtin in gastrulation, BP.TT; 21/04174-0 - Study of the bipolar disorder and Alzheimer's disease comorbidity using 3D cultures of decellularized brain extracellular matrix, BP.TT; 20/10725-6 - Evaluation of purinergic receptors in the comorbidity of bipolar disorder and Alzheimer's Disease, BP.DD; 20/07609-4 - Study of the neuroregeneration process triggered by bradykinin in the animal model of Parkinson's Disease, BP.IC; 19/24553-5 - The role of P2Y1 receptor in Parkinsons Disease, BP.DR; 19/26852-0 - Study of purinergic receptors antagonism in the inflammatory process and microglial cells activation using in vitro and in vivo models of Parkinsons Disease, BP.PD; 18/17504-5 - Behavioral and molecular effects of pharmacological modulation of the P2Y2 receptors in an animal model of Alzheimer's Disease, BP.PD; 19/03494-0 - Silencing of B1R and B2R kinin receptors in the BV-2 microglial cell line as a model of neuroinflammation response, BP.IC; 15/15826-7 - Collagen hydrogel modified by bi-functional recombinant protein for transplantation of neural stem cells for the treatment of neurodegenerative disorder, BP.PD; 15/19478-3 - Role of kinin-B2 receptor in pathogenesis and progression of familial Alzheimer's Disease: from neurogenesis and immune response to cognition, BP.PD; 15/13345-1 - Huntington's disease: Huntingtin roles during cell fate decision, BP.PD - associated scholarships

Abstract

The biological process of neurogenesis that consists of differentiation of neural stem cells (NSC) into neurons, occurs both in embryonic and adult phases. Therefore, NSC are being proposed as interesting tools for nervous system tissue regeneration and restoration of physiological conditions, as well as models for elucidation of pathophysiological development of neurological diseases. Previous studies of our laboratory showed several signalling pathways involved in NSC development, especially through purinergic and kininergic receptors, whose modulation is essential in neural phenotype determination. Besides participating in adult brain neurotransmition in health conditions, their modulation reverted pathologic scenarios in animal and in vitro models of Parkinson's and Alzheimer's Disease. Taking into account these findings of our group, we proposed here a more profound investigation regarding mechanisms underlying in these effects, elucidating how purinergic and kininergic systems are involved and potential therapeutic targets for neurologic pathologies, especially associated with neurodegeneration/ regeneration and inflammatory process. Thus, the neurogenic, neuroprotective and immunomodulatory effects of purinergic and kininergic signalling will be studied in Parkinson's, Alzheimer's and Huntington's diseases and in bipolar disorder. Moreover, new tools based on nanotechnology, as biopolymers conjugated to bradikinin, will be used in NSC transplantation improvement as therapeutic alternative in animal models. (AU)

Scientific publications

(87)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

WANG, TAO; ULRICH, HENNING; SEMYANOV, ALEXEY; ILLES, PETER; TANG, YONG. Optical control of purinergic signaling. PURINERGIC SIGNALLING, JUN 2021. (18/07366-4)

VIVIANI, LUCAS G.; PICCIRILLO, ERIKA; ULRICH, HENNING; AMARAL, ANTONIA T-DO. Virtual Screening Approach for the Identification of Hydroxamic Acids as Novel Human Ecto-5 `-Nucleotidase Inhibitors. JOURNAL OF CHEMICAL INFORMATION AND MODELING, v. 60, n. 2, p. 621-630, FEB 2020. (14/07248-0, 12/50880-4, 18/24678-0, 12/06633-2, 18/07366-4, 13/07937-8, 18/06381-0)

GLASER, TALITA; SHIMOJO, HIROMI; RIBEIRO, DEIDIANE ELISA; MARTINS, PATRICIA PEREIRA LOPES; BECO, RENATA PEREIRA; KOSINSKI, MICHAL; SAMPAIO, VANESSA FERNANDES ARNAUD; CORREA-VELLOSO, JULIANA; OLIVEIRA-GIACOMELLI, AGATHA; LAMEU, CLAUDIANA; et al. ATP and spontaneous calcium oscillations control neural stem cell fate determination in Huntington's disease: a novel approach for cell clock research. MOLECULAR PSYCHIATRY, APR 2020. (18/07366-4, 12/50880-4, 15/13345-1)

PILLAT, MICHELI MAINARDI; OLIVEIRA-GIACOMELLI, AGATHA; DAS NEVES OLIVEIRA, MONA; ANDREJEW, ROBERTA; TURRINI, NATALIA; BARANOVA, JULIANA; LAH TURNSEK, TAMARA; ULRICH, HENNING. Mesenchymal stem cell-glioblastoma interactions mediated via kinin receptors unveiled by cytometry. Cytometry Part A, v. 99, n. 2, SI, JAN 2021. (18/07366-4, 20/10725-6, 12/50880-4, 19/24553-5, 19/26852-0)

BIANCHETTI, MARIA E.; FERREIRA, ANA FLAVIA F.; BRITTO, LUIZ R. G.. Inhibition of neuroinflammation by GIBH-130 (AD-16) reduces neurodegeneration, motor deficits, and proinflammatory cytokines in a hemiparkinsonian model. FRONTIERS IN NEUROANATOMY, v. 18, p. 12-pg., 2024-12-16. (18/07366-4, 22/14846-8, 22/14820-9, 23/05618-4, 20/02109-3)

KRUGER, ARNE; DE JESUS SANTOS, ANA PAULA; DE SA, VANESSA; ULRICH, HENNING; WRENGER, CARSTEN. Aptamer Applications in Emerging Viral Diseases. PHARMACEUTICALS, v. 14, n. 7, JUL 2021. (18/07366-4, 15/26722-8, 17/03966-4, 15/26642-4)

ALAVARSE, ALEX CARVALHO; SILVA, JEAN BEZERRA; ULRICH, HENNING; SIQUEIRA PETRI, DENISE FREITAS. Poly(vinyl alcohol)/sodium alginate/magnetite composites: magnetic force microscopy for tracking magnetic domains. SOFT MATTER, v. 19, n. 14, p. 11-pg., 2023-03-15. (18/13492-2, 18/07366-4, 20/01907-3, 19/08178-0)

ANDREJEW, ROBERTA; OLIVEIRA-GIACOMELLI, AGATHA; RIBEIRO, DEIDIANE ELISA; GLASER, TALITA; ARNAUD-SAMPAIO, VANESSA FERNANDES; LAMEU, CLAUDIANA; ULRICH, HENNING. The P2X7 Receptor: Central Hub of Brain Diseases. FRONTIERS IN MOLECULAR NEUROSCIENCE, v. 13, JUL 31 2020. (15/13345-1, 18/17504-5, 19/24553-5, 15/19128-2, 18/07366-4)

CORREA-VELLOSO, JULIANA C.; BARTLETT, PAULA J.; BRUMER, ROBERT; GASPERS, LAWRENCE D.; ULRICH, HENNING; THOMAS, ANDREW P.. Receptor-specific Ca2+ oscillation patterns mediated by differential regulation of P2Y purinergic receptors in rat hepatocytes. ISCIENCE, v. 24, n. 10, OCT 22 2021. (18/07366-4)

OLIVEIRA-GIACOMELLI, AGATHA; PETIZ, LYVIA LINTZMAIER; ANDREJEW, ROBERTA; TURRINI, NATALIA; SILVA, JEAN BEZERRA; SACK, ULRICH; ULRICH, HENNING. Role of P2X7 Receptors in Immune Responses During Neurodegeneration. FRONTIERS IN CELLULAR NEUROSCIENCE, v. 15, MAY 26 2021. (18/08426-0, 19/24553-5, 18/07366-4, 19/26852-0, 20/10725-6)

ARNAUD-SAMPAIO, VANESSA FERNANDES; ALVES RABELO, IZADORA LORRANY; ULRICH, HENNING; LAMEU, CLAUDIANA. The P2X7 Receptor in the Maintenance of Cancer Stem Cells, Chemoresistance and Metastasis. STEM CELL REVIEWS AND REPORTS, v. 16, n. 2, p. 288-300, APR 2020. (15/19128-2, 18/07366-4, 17/06132-7)

ARNAUD-SAMPAIO, VANESSA F.; RABELO, IZADORA L. A.; BENTO, CAROLINA A.; GLASER, TALITA; BEZERRA, JEAN; COUTINHO-SILVA, ROBSON; ULRICH, HENNING; LAMEU, CLAUDIANA. Using Cytometry for Investigation of Purinergic Signaling in Tumor-Associated Macrophages. Cytometry Part A, v. 97, n. 11, JUL 2020. (17/06132-7, 15/13345-1, 18/07366-4, 18/14993-5, 15/19128-2)

DE SOUZA, ANACLETO SILVA; DE FREITAS AMORIM, VITOR MARTINS; GUARDIA, GABRIELA D. A.; DOS SANTOS, FILIPE F.; ULRICH, HENNING; GALANTE, PEDRO A. F.; DE SOUZA, ROBSON FRANCISCO; GUZZO, CRISTIANE RODRIGUES. Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern: A Perspective for Emerging More Transmissible and Vaccine-Resistant Strains. Viruses-Basel, v. 14, n. 4, p. 21-pg., 2022-04-01. (18/07366-4, 20/06091-1, 19/00195-2, 16/09047-8, 20/14158-9, 20/04680-0, 17/18246-7, 17/19541-2, 18/15579-8)

ARNAUD-SAMPAIO, VANESSA FERNANDES; BENTO, CAROLINA ADRIANE; GLASER, TALITA; ADINOLFI, ELENA; ULRICH, HENNING; LAMEU, CLAUDIANA. P2X7 receptor isoform B is a key drug resistance mediator for neuroblastoma. FRONTIERS IN ONCOLOGY, v. 12, p. 19-pg., 2022-08-25. (18/07366-4, 15/19128-2)

BISSACOTTI, BIANCA FAGAN; COPETTI, PRISCILA MARQUEZAN; BOTTARI, NATHIELI BIANCHIN; PALMA, TAIS VIDAL; PILLAT, MICHELI MAINARDI; DE ANDRADE, CINTHIA MELAZZO; MELCHIORS MORSCH, VERA MARIA; ULRICH, HENNING; DA SILVA, ALEKSANDRO SCHAFER. Curcumin modulates neurogliogenesis and purinergic receptor expression in neural precursor cells infected with Toxoplasma gondii. Parasitology Research, v. 122, n. 1, p. 8-pg., 2022-10-25. (18/07366-4)

PILLAT, MICHELI MAINARDI; AYUPE, ANA CAROLINA; JUVENAL, GUILHERME; MEINERZ, CARINE; GLASER, TALITA; DA SILVA PELLEGRINA, DIOGO VIEIRA; PAIVA, DAISYLEA SOUZA; MELLO, CARLOS FERNANDO; LONGO, BEATRIZ MONTEIRO; REIS, EDUARDO MORAES; et al. Differentiated Embryonic Neurospheres from Familial Alzheimer's Disease Model Show Innate Immune and Glial Cell Responses. STEM CELL REVIEWS AND REPORTS, v. 19, n. 6, p. 12-pg., 2023-05-02. (18/07366-4, 18/08426-0)

F. FERREIRA, ANA FLAVIA; G. BRITTO, LUIZ ROBERTO. The transient receptor potential melastatin 2: a new therapeutical target for Parkinson's disease?. NEURAL REGENERATION RESEARCH, v. 18, n. 8, p. 5-pg., 2023-08-01. (18/07366-4, 20/02109-3)

TOMCZYK, MARTA; GLASER, TALITA; SLOMINSKA, EWA M.; ULRICH, HENNING; SMOLENSKI, RYSZARD T.. Purine Nucleotides Metabolism and Signaling in Huntington's Disease: Search for a Target for Novel Therapies. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 22, n. 12, JUN 2021. (18/07366-4)

DO NASCIMENTO, RAVENA PEREIRA; DOS SANTOS, BALBINO LINO; AMPARO, JESSIKA ALVES OLIVEIRA; SOARES, JANAINA RIBEIRO PEREIRA; DA SILVA, KARINA COSTA; SANTANA, MONIQUE REIS; ALMEIDA, AUREA MARIA ALVES NUNES; DA SILVA, VICTOR DIOGENES AMARAL; COSTA, MARIA DE FATIMA DIAS; ULRICH, HENNING; et al. euroimmunomodulatory Properties of Flavonoids and Derivates: A Potential Action as Adjuvants for the Treatment of Glioblastom. PHARMACEUTICS, v. 14, n. 1, JAN 2022. (18/07366-4)

PILLAT, MICHELI MAINARDI; KRUGER, ARNE; FERREIRA GUIMARAES, LARA MENDES; LAMEU, CLAUDIANA; DE SOUZA, EDMARCIA ELISA; WRENGER, CARSTEN; ULRICH, HENNING. Insights in Chloroquine Action: Perspectives and Implications in Malaria andCOVID-19. Cytometry Part A, v. 97, n. 9, AUG 2020. (18/07366-4, 18/08820-0, 15/26722-8, 15/19128-2)

BOTTARI, NATHIELI B.; REICHERT, KARINE PAULA; FRACASSO, MATEUS; DUTRA, ANIELEN; ASSMANN, CHARLES ELIAS; ULRICH, HENNING; CHITOLINA SCHETINGER, MARIA ROSA; MORSCH, VERA M.; DA SILVA, ALEKSANDRO SCHAFER. Neuroprotective role of resveratrol mediated by purinergic signalling in cerebral cortex of mice infected by Toxoplasma gondii. Parasitology Research, v. 119, n. 9, p. 9-pg., 2020-07-17. (18/07366-4)

REICHERT, KARINE P.; PILLAT, MICHELI M.; SCHETINGER, MARIA ROSA C.; BOTTARI, NATHIELI B.; PALMA, V, TAIS; ASSMANN, CHARLES E.; GUTIERRES, JESSIE M.; ULRICH, HENNING; ANDRADE, CINTHIA M.; EXLEY, CHRISTOPHER; et al. Aluminum-induced alterations of purinergic signalling in embryonic neural progenitor cells. Chemosphere, v. 251, JUL 2020. (18/07366-4, 15/19478-3)

DE SOUZA, ANACLETO SILVA; AMORIM, VITOR MARTINS DE FREITAS; GUARDIA, GABRIELA D. A.; DOS SANTOS, FELIPE R. C.; DOS SANTOS, FILIPE F.; DE SOUZA, ROBSON FRANCISCO; JUVENAL, GUILHERME DE ARAUJO; HUANG, YIHUA; GE, PINGJU; JIANG, YINAN; et al. Molecular Dynamics Analysis of Fast-Spreading Severe Acute Respiratory Syndrome Coronavirus 2 Variants and Their Effects on the Interaction with Human Angiotensin-Converting Enzyme 2. ACS OMEGA, v. 7, n. 35, p. 10-pg., 2022-08-24. (20/06091-1, 17/18246-7, 17/19541-2, 20/04680-0, 19/00195-2, 16/09047-8, 18/15579-8, 18/07366-4, 20/14158-9)

CORREA-VELLOSO, JULIANA C.; LINARDI, ALESSANDRA M.; GLASER, TALITA; VELLOSO, FERNANDO J.; RIVAS, MARIA P.; LEITE, RENATA E. P.; GRINBERG, LEA T.; ULRICH, HENNING; AKINS, MICHAEL R.; CHIAVEGATTO, SILVANA; et al. Fmr1 exon 14 skipping in late embryonic development of the rat forebrain. BMC NEUROSCIENCE, v. 23, n. 1, p. 15-pg., 2022-05-31. (18/07366-4, 17/06100-8, 19/10868-4, 11/14329-9, 09/01333-8)

SEMEANO, ANA T.; TOFOLI, FABIANO A.; CORREA-VELLOSO, JULIANA C.; DE JESUS SANTOS, ANA P.; OLIVEIRA-GIACOMELLI, AGATHA; CARDOSO, RAFAELA R.; PESSOA, MATEUS A.; DA ROCHA, EDROALDO LUMMERTZ; RIBEIRO, GUSTAVO; FERRARI, MERARI F. R.; et al. Effects of Magnetite Nanoparticles and Static Magnetic Field on Neural Differentiation of Pluripotent Stem Cells. STEM CELL REVIEWS AND REPORTS, v. 18, n. 4, p. 18-pg., 2022-03-24. (18/07366-4, 19/26852-0, 16/14513-8, 13/08028-1, 18/07592-4, 13/08135-2)

FERREIRA, ANA FLAVIA F.; ULRICH, HENNING; FENG, ZHONG-PING; SUN, HONG-SHUO; BRITTO, LUIZ ROBERTO. Neurodegeneration and glial morphological changes are both prevented by TRPM2 inhibition during the progression of a Parkinson's disease mouse model. Experimental Neurology, v. 377, p. 15-pg., 2024-04-25. (20/02109-3, 18/07366-4, 22/14820-9)

NAALDIJK, YAHAIRA; SHERMAN, LAUREN S.; TURRINI, NATALIA; KENFACK, YANNICK; RATAJCZAK, MARIUSZ Z.; SOUAYAH, NIZAR; RAMESHWAR, PRANELA; ULRICH, HENNING. Mesenchymal Stem Cell-Macrophage Crosstalk Provides Specific Exosomal Cargo to Direct Immune Response Licensing of Macrophages during Inflammatory Responses. STEM CELL REVIEWS AND REPORTS, v. 20, n. 1, p. 19-pg., 2023-10-18. (17/23604-0, 20/10725-6, 12/50880-4, 18/07366-4, 15/14343-2)

JUVENAL, GUILHERME; HIGA, GUILHERME SHIGUETO VILAR; BONFIM MARQUES, LUCAS; TESSARI ZAMPIERI, THAIS; COSTA VIANA, FELIPE JOSE; BRITTO, LUIZ R.; TANG, YONG; ILLES, PETER; DI VIRGILIO, FRANCESCO; ULRICH, HENNING; et al. Regulation of GABAergic neurotransmission by purinergic receptors in brain physiology and disease. PURINERGIC SIGNALLING, v. N/A, p. 29-pg., 2024-07-24. (22/00850-3, 22/09277-4, 18/07366-4, 22/10950-5)

VIVIANI, LUCAS G.; PICCIRILLO, ERIKA; ULRICH, HENNING; AMARAL, ANTONIA T-DO. Virtual Screening Approach for the Identification of Hydroxamic Acids as Novel Human Ecto-5 '-Nucleotidase Inhibitors. JOURNAL OF CHEMICAL INFORMATION AND MODELING, v. 60, n. 2, p. 10-pg., 2020-02-01. (13/07937-8, 12/50880-4, 18/06381-0, 18/24678-0, 12/06633-2, 18/07366-4, 14/07248-0)

IKEBARA, JULIANE MIDORI; JORGE, RENATA SILVA; MARINHO, LUCIANA SIMOES RAFAGNIN; HIGA, GUILHERME SHIGUETO VILAR; ADHIKARI, AVISHEK; REIS, FERNANDO M. C. V.; BORGES, FERNANDO S.; ULRICH, HENNING; TAKADA, SILVIA HONDA; DE PASQUALE, ROBERTO; et al. Hippocampal Interneurons Shape Spatial Coding Alterations in Neurological Disorders. Molecular Neurobiology, v. N/A, p. 24-pg., 2025-05-20. (20/16268-6, 20/11667-0, 22/00850-3, 22/09277-4, 18/07366-4)

RIBEIRO, RAUL IZIDORO; CARVALHO, GUSTAVO ALMEIDA; CHIARELI, RAPHAELA ALMEIDA; LIMA, ISABEL VIEIRA DE ASSIS; BELLOZI, PAULA MARIA QUAGLIO; OLIVEIRA-LIMA, ONESIA CRISTINA; GIACOMELLI, AGATHA OLIVEIRA; BIRBRAIR, ALEXANDER; GOMEZ, RENATO SANTIAGO; DE OLIVEIRA, ANTONIO CARLOS PINHEIRO; et al. Glycine transporter-1 inhibition by NFPS promotes neuroprotection against striatal damage models. Neuroscience Letters, v. 826, p. 7-pg., 2024-03-10. (18/07366-4, 18/08426-0)

PEREZ, REBECA; GLASER, TALITA; VILLEGAS, CECILIA; BURGOS, VIVIANA; ULRICH, HENNING; PAZ, CRISTIAN. Therapeutic Effects of Cannabinoids and Their Applications in COVID-19 Treatment. LIFE-BASEL, v. 12, n. 12, p. 19-pg., 2022-12-01. (18/07366-4)

CAVALCANTE, DANIEL PEREIRA; NUNES, ANTONIO ITALO DOS; DA SILVA, EDUARDO ROSA; DE CARVALHO, GUSTAVO ALMEIDA; CHIARELI, RAPHAELA ALMEIDA; OLIVEIRA-LIMA, ONESIA CRISTINA; ORTIZ-LEONCINI, GIOVANNI; ULRICH, HENNING; GOMEZ, RENATO SANTIAGO; PINTO, MAURO CUNHA XAVIER. GlyT1 inhibition promotes neuroprotection in the middle cerebral artery occlusion model through the activation of GluN2A-containing NMDAR. Experimental Neurology, v. 383, p. 13-pg., 2024-10-20. (18/07366-4)

GLASER, TALITA; OLIVEIRA-GIACOMELLI, AGATHA; PETIZ, LYVIA LINTZMAIER; RIBEIRO, DEIDIANE ELISA; ANDREJEW, ROBERTA; ULRICH, HENNING. Antagonistic Roles of P2X7 and P2Y2 Receptors in Neurodegenerative Diseases. FRONTIERS IN PHARMACOLOGY, v. 12, p. 7-pg., 2021-04-12. (18/08426-0, 18/17504-5, 19/24553-5, 19/26852-0, 15/13345-1, 18/07366-4)

PILLAT, MICHELI MAINARDI; OLIVEIRA-GIACOMELLI, AGATHA; DAS NEVES OLIVEIRA, MONA; ANDREJEW, ROBERTA; TURRINI, NATALIA; BARANOVA, JULIANA; LAH TURNSEK, TAMARA; ULRICH, HENNING. Mesenchymal stem cell-glioblastoma interactions mediated via kinin receptors unveiled by cytometry. Cytometry Part A, v. 99, n. 2, p. 12-pg., 2021-01-13. (12/50880-4, 20/10725-6, 19/24553-5, 19/26852-0, 18/07366-4)

OLIVEIRA-LIMA, ONESIA CRISTINA; DE CARVALHO, GUSTAVO ALMEIDA; ASSUNCAO, LEANDRO DO PRADO; BAILAO, ALEXANDRE MELO; ULRICH, HENNING; MARQUES, BRUNO LEMES; DE OLIVEIRA, ANTONIO CARLOS PINHEIRO; GOMEZ, RENATO SANTIAGO; PINTO, MAURO CUNHA XAVIER. GlyT1 Inhibition by NFPS Promotes Neuroprotection in Amyloid-β-Induced Alzheimer's Disease Animal Model. Neurochemical Research, v. 49, n. 9, p. 21-pg., 2024-06-18. (18/07366-4, 18/08426-0)

SINGULANI, MONIQUE PATRICIO; FERREIRA, ANA FLAVIA FERNANDES; FIGUEROA, PAULINA SEPULVEDA; CUYUL-VASQUEZ, IVAN; TALIB, LEDA LEME; BRITTO, LUIZ ROBERTO; FORLENZA, ORESTES VICENTE. Lithium and disease modification: A systematic review and meta-analysis in Alzheimer's and Parkinson's disease. AGEING RESEARCH REVIEWS, v. 95, p. 20-pg., 2024-02-24. (20/02109-3, 18/07366-4, 21/06378-1, 14/50873-3)

ALAVARSE, ALEX C.; DA SILVA, RAFAEL L. C. G.; GHAFFARI BOHLOULI, PEJMAN; CORNEJO, DANIEL; ULRICH, HENNING; SHAVANDI, AMIN; PETRI, DENISE F. S.. Magnetic Force Microscopy and Nanoindentation on 3D Printed Magnetic Scaffolds for Neuronal Cell Growth. ACS APPLIED POLYMER MATERIALS, v. 6, n. 2, p. 12-pg., 2023-12-26. (19/22671-0, 20/01907-3, 22/08442-1, 18/07366-4, 18/13492-2)

YE, QING; LIN, SI-SI; ULRICH, HENNING; TANG, YONG. Decoupling SERT-nNOS Interaction to Generate Fast-Onset Antidepressants. NEUROSCIENCE BULLETIN, v. 39, n. 8, p. 3-pg., 2023-03-28. (18/07366-4)

VILLEGAS, CECILIA; GONZALEZ-CHAVARRIA, IVAN; BURGOS, VIVIANA; ITURRA-BEIZA, HECTOR; ULRICH, HENNING; PAZ, CRISTIAN. Epothilones as Natural Compounds for Novel Anticancer Drugs Development. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 24, n. 7, p. 20-pg., 2023-04-01. (18/07366-4)

SCHEUERMANN, KARINA; VIANA, CELSO TARSO RODRIGUES; DOS REIS, DIEGO CARLOS; DE LAZARI, MARCELA GUIMARAES TAKAHASHI; ORELLANO, LAURA ALEJANDRA ARIZA; MACHADO, CLARA TOLENTINO; DOS SANTOS, LETICIA CRISTINE CARDOSO; ULRICH, HENNING; CAPETTINI, LUCIANO SANTOS AGGUM; ANDRADE, SILVIA PASSOS; et al. Amitriptyline efficacy in decreasing implant-induced foreign body reaction. IUBMB Life, v. N/A, p. 11-pg., 2023-04-22. (18/07366-4)

OLIVEIRA-GIACOMELLI, AGATHA; ALBINO, CAROLINA M.; NOBREGA DE SOUZA, HELLIO DANNY; CORREA-VELLOSO, JULIANA; DE JESUS SANTOS, ANA PAULA; BARANOVA, JULIANA; ULRICH, HENNING. P2Y6 and P2X7 Receptor Antagonism Exerts Neuroprotective/ Neuroregenerative Effects in an Animal Model of Parkinson's Disease. FRONTIERS IN CELLULAR NEUROSCIENCE, v. 13, NOV 8 2019. (12/50880-4, 18/07366-4, 17/24400-9)

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CAO, XIN; YIN, HAI-YAN; ULRICH, HENNING; SEMYANOV, ALEXEY; TANG, YONG. A Neural Circuit for Gut-Induced Sugar Preference. NEUROSCIENCE BULLETIN, v. 37, n. 5, p. 754-756, MAY 2021. (18/07366-4)

RABELO, IZADORA LORRANY ALVES; ARNAUD-SAMPAIO, VANESSA FERNANDES; ADINOLFI, ELENA; ULRICH, HENNING; LAMEU, CLAUDIANA. Cancer Metabostemness and Metabolic Reprogramming via P2X7 Receptor. CELLS, v. 10, n. 7, JUL 2021. (17/06132-7, 15/19128-2, 18/07366-4)

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TROMBETTA-LIMA, MARINA; ASSIS-RIBAS, THAIS; CINTRA, RICARDO C.; CAMPEIRO, JOANA D.; GUERREIRO, JULIANO R.; WINNISCHOFER, SHEILA M. B.; NASCIMENTO, ISIS C. C.; ULRICH, HENNING; HAYASHI, MIRIAN A. F.; SOGAYAR, MARI C.. Impact of Reck expression and promoter activity in neuronal in vitro differentiation. MOLECULAR BIOLOGY REPORTS, v. 48, n. 2, FEB 2021. (18/20014-0, 16/05311-2, 18/07366-4, 14/50891-1, 19/13112-8, 15/26328-8, 16/18277-7, 12/50880-4, 17/02413-1)

ALAVARSE, ALEX CARVALHO; FRACHINI, EMILLI CAROLINE G.; SILVA, JEAN BEZERRA; PEREIRA, RAFAEL DOS SANTOS; ULRICH, HENNING; SIQUEIRA PETRI, DENISE FREITAS. Amino acid decorated xanthan gum coatings: Molecular arrangement and cell adhesion. CARBOHYDRATE POLYMER TECHNOLOGIES AND APPLICATIONS, v. 4, p. 11-pg., 2022-06-13. (20/01907-3, 18/07366-4, 18/13492-2)

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GONCALVES, MARIA CAROLINA BITTENCOURT; GLASER, TALITA; OLIVEIRA, SOPHIA LA BANCA DE; ULRICH, HENNING. Adenosinergic-Dopaminergic Signaling in Mood Disorders: A Mini-Review. JOURNAL OF CAFFEINE AND ADENOSINE RESEARCH, v. 10, n. 3, p. 10-pg., 2020-09-01. (18/07366-4, 15/13345-1)

OLIVEIRA, MONA N.; PILLAT, MICHELI M.; BARANOVA, JULIANA; ANDREJEW, ROBERTA; DOS SANTOS, BALBINO LINO; COSTA, SILVIA LIMA; LAH, TAMARA T.; ULRICH, HENNING. Glioblastoma cell invasiveness and epithelial-to-mesenchymal transitioning are modulated by kinin receptors. ADVANCES IN CANCER BIOLOGY-METASTASIS, v. 4, p. 12-pg., 2022-07-01. (12/50880-4, 18/07366-4, 19/24553-5)

PETIZ, LYVIA LINTZMAIER; GLASER, TALITA; SCHARFSTEIN, JULIO; RATAJCZAK, MARIUSZ Z.; ULRICH, HENNING. P2Y14 Receptor as a Target for Neutrophilia Attenuation in Severe COVID-19 Cases: From Hematopoietic Stem Cell Recruitment and Chemotaxis to Thrombo-inflammation. STEM CELL REVIEWS AND REPORTS, v. 17, n. 1, p. 12-pg., 2021-02-11. (18/07366-4, 15/13345-1)

PARK, SEUNG EUN; FERREIRA, ANA FLAVIA F.; KWON, HYEOKBIN; YU, JEONGWOO; DINIZ, LEILA; ULRICH, HENNING; BRITTO, LUIZ R. G.; KIM, EUNHA. The role of interleukin-17 in neurological disorders. Animal Cells and Systems, v. 29, n. 1, p. 15-pg., 2025-12-31. (18/07366-4, 22/14846-8, 20/02109-3, 22/14820-9)

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RATAJCZAK, MARIUSZ Z.; ADAMIAK, MATEUSZ; BUJKO, KAMILA; THAPA, ARJUN; PENSATO, VALENTINA; KUCIA, MAGDA; RATAJCZAK, JANINA; ULRICH, HENNING. Innate immunity orchestrates the mobilization and homing of hematopoietic stem/progenitor cells by engaging purinergic signaling-an update. PURINERGIC SIGNALLING, MAY 2020. (18/07366-4)

PALMA, TAIS VIDAL; LENZ, LUANA SUELING; BOTTARI, NATHIELE BIANCHIN; PEREIRA, ALINE; SCHETINGER, MARIA ROSA CHITOLINA; MORSCH, VERA MARIA; ULRICH, HENNING; PILLAT, MICHELI MAINARDI; DE ANDRADE, CINTHIA MELAZZO. Berberine induces apoptosis in glioblastoma multiforme U87MG cells via oxidative stress and independent of AMPK activity. MOLECULAR BIOLOGY REPORTS, v. 47, n. 6, MAY 2020. (18/07366-4)

CARVALHO, GUSTAVO ALMEIDA; CAVALCANTE, DANIEL PEREIRA; PARREIRA, RICARDO CAMBRAIA; CHIARELI, RAPHAELA ALMEIDA; LEONCINI, GIOVANNI ORTIZ; GOMEZ, RENATO SANTIAGO; ULRICH, HENNING; CAIXETA, LEONARDO FERREIRA; OLIVEIRA-LIMA, ONESIA CRISTINA; PINTO, MAURO CUNHA XAVIER. Neurobiology of L-proline: From molecules to behavior. Neuroscience, v. 568, p. 14-pg., 2025-01-19. (18/07366-4)

BENTO, CAROLINA ADRIANE; ARNAUD-SAMPAIO, VANESSA FERNANDES; GLASER, TALITA; ADINOLFI, ELENA; COUTINHO-SILVA, ROBSON; ULRICH, HENNING; LAMEU, CLAUDIANA. P2X7 receptor in macrophage polarization and its implications in neuroblastoma tumor behavior. PURINERGIC SIGNALLING, v. N/A, p. 18-pg., 2024-10-19. (18/14993-5, 22/11093-9, 18/07366-4, 15/19128-2)