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Purine and kinin receptors as targets of study and therapeutic interventions in neurological diseases

Grant number: 18/07366-4
Support Opportunities:Research Projects - Thematic Grants
Duration: April 01, 2019 - March 31, 2025
Field of knowledge:Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
Principal Investigator:Alexander Henning Ulrich
Grantee:Alexander Henning Ulrich
Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Pesquisadores principais:
( Atuais )
Luiz Roberto Giorgetti de Britto
Pesquisadores principais:
( Anteriores )
Marimélia Aparecida Porcionatto
Associated researchers:Beatriz de Oliveira Monteiro ; Claudiana Lameu ; Cristiane Otero Reis Salum ; João Bosco Pesquero ; Luiz Henrique Catalani ; Marimélia Aparecida Porcionatto ; Mayana Zatz ; Roberto De Pasquale ; Roberto Kopke Salinas ; Silvana Chiavegatto
Associated scholarship(s):24/04690-6 - The effect of caffeine and purinergic signaling in three-dimensional models of Alzheimer's Disease using bioprinting, BP.PD
23/09308-0 - In vitro evaluation of the modulation of purinergic receptors P2Y6, P2Y12, and P2X7 in a microglial cell line, BP.IC
23/04077-0 - Study of the co-morbidity of Bipolar Disorder and Alzheimer's Disease using 3D cultures of decellularized brain matrices., BP.TT
+ associated scholarships 23/06673-9 - Role of purinergic receptors and huntingtin in gastrulation., BP.TT
22/10950-5 - Selection and evaluation of proteins and fundamental mechanisms for the formation of long-term memory, BP.DD
22/09277-4 - Hippocampal pathological plasticity in neonatal anoxia, BP.PD
22/10616-8 - Assessment of spatial memory, cognition and learning in a murine model of hippocampal immaturity, BP.IC
22/12888-5 - Role of the P2X7 purinergic receptor in microglia-mediated neurotoxicity in models of Alzheimer's disease and its possible correlation with the modulation of neurogenesis, BP.IC
22/01304-2 - In vitro studies of the role of P2X4 receptors on inflammatory processes involved in Parkinsons Disease, BP.MS
21/01478-8 - Molecular effects of pharmacological modulation of P2Y6 receptors in an in vitro model for the study of Alzheimer's Disease, BP.MS
21/00060-0 - Role of P2Y14 receptor modulation in the hippocampal neuroinflammatory responses in in vitro and in vivo models of Alzheimer's Disease, BP.PD
21/05279-0 - The role of purinergic receptors and Huntingtin in gastrulation, BP.TT
21/04174-0 - Study of the bipolar disorder and Alzheimer's disease comorbidity using 3D cultures of decellularized brain extracellular matrix, BP.TT
20/10725-6 - Evaluation of purinergic receptors in the comorbidity of bipolar disorder and Alzheimer's Disease, BP.DD
20/07609-4 - Study of the neuroregeneration process triggered by bradykinin in the animal model of Parkinson's Disease, BP.IC
19/24553-5 - The role of P2Y1 receptor in Parkinsons Disease, BP.DR
19/26852-0 - Study of purinergic receptors antagonism in the inflammatory process and microglial cells activation using in vitro and in vivo models of Parkinsons Disease, BP.PD
18/17504-5 - Behavioral and molecular effects of pharmacological modulation of the P2Y2 receptors in an animal model of Alzheimer's Disease, BP.PD
19/03494-0 - Silencing of B1R and B2R kinin receptors in the BV-2 microglial cell line as a model of neuroinflammation response, BP.IC
15/15826-7 - Collagen hydrogel modified by bi-functional recombinant protein for transplantation of neural stem cells for the treatment of neurodegenerative disorder, BP.PD
15/19478-3 - Role of kinin-B2 receptor in pathogenesis and progression of familial Alzheimer's Disease: from neurogenesis and immune response to cognition, BP.PD
15/13345-1 - Huntington's disease: Huntingtin roles during cell fate decision, BP.PD - associated scholarships

Abstract

The biological process of neurogenesis that consists of differentiation of neural stem cells (NSC) into neurons, occurs both in embryonic and adult phases. Therefore, NSC are being proposed as interesting tools for nervous system tissue regeneration and restoration of physiological conditions, as well as models for elucidation of pathophysiological development of neurological diseases. Previous studies of our laboratory showed several signalling pathways involved in NSC development, especially through purinergic and kininergic receptors, whose modulation is essential in neural phenotype determination. Besides participating in adult brain neurotransmition in health conditions, their modulation reverted pathologic scenarios in animal and in vitro models of Parkinson's and Alzheimer's Disease. Taking into account these findings of our group, we proposed here a more profound investigation regarding mechanisms underlying in these effects, elucidating how purinergic and kininergic systems are involved and potential therapeutic targets for neurologic pathologies, especially associated with neurodegeneration/ regeneration and inflammatory process. Thus, the neurogenic, neuroprotective and immunomodulatory effects of purinergic and kininergic signalling will be studied in Parkinson's, Alzheimer's and Huntington's diseases and in bipolar disorder. Moreover, new tools based on nanotechnology, as biopolymers conjugated to bradikinin, will be used in NSC transplantation improvement as therapeutic alternative in animal models. (AU)

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Scientific publications (70)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HUANG, ZHAO; XIE, NA; ILLES, PETER; DI VIRGILIO, FRANCESCO; ULRICH, HENNING; SEMYANOV, ALEXEY; VERKHRATSKY, ALEXEI; SPERLAGH, BEATA; YU, SHU-GUANG; HUANG, CANHUA; et al. From purines to purinergic signalling: molecular functions and human diseases. SIGNAL TRANSDUCTION AND TARGETED THERAPY, v. 6, n. 1, . (18/07366-4)
MIRANDA, ALVARO; MONTIEL, ENRIQUE; ULRICH, HENNING; PAZ, CRISTIAN. Selective Secretase Targeting for Alzheimer's Disease Therapy. JOURNAL OF ALZHEIMER'S DISEASE, v. 81, n. 1, p. 1-17, . (18/07366-4)
RATAJCZAK, MARIUSZ Z.; ADAMIAK, MATEUSZ; BUJKO, KAMILA; THAPA, ARJUN; PENSATO, VALENTINA; KUCIA, MAGDA; RATAJCZAK, JANINA; ULRICH, HENNING. Innate immunity orchestrates the mobilization and homing of hematopoietic stem/progenitor cells by engaging purinergic signaling-an update. PURINERGIC SIGNALLING, . (18/07366-4)
PALMA, TAIS VIDAL; LENZ, LUANA SUELING; BOTTARI, NATHIELE BIANCHIN; PEREIRA, ALINE; SCHETINGER, MARIA ROSA CHITOLINA; MORSCH, VERA MARIA; ULRICH, HENNING; PILLAT, MICHELI MAINARDI; DE ANDRADE, CINTHIA MELAZZO. Berberine induces apoptosis in glioblastoma multiforme U87MG cells via oxidative stress and independent of AMPK activity. MOLECULAR BIOLOGY REPORTS, v. 47, n. 6, . (18/07366-4)
SANTOS, ANDERSON K.; GOMES, KATIA N.; PARREIRA, RICARDO C.; SCALZO, SERGIO; PINTO, MAURO C. X.; SANTIAGO, HELTON C.; BIRBRAIR, ALEXANDER; SACK, ULRICH; ULRICH, HENNING; RESENDE, RODRIGO R.. Mouse Neural Stem Cell Differentiation and Human Adipose Mesenchymal Stem Cell Transdifferentiation Into Neuron-and Oligodendrocyte-like Cells With Myelination Potential. STEM CELL REVIEWS AND REPORTS, . (18/07366-4)
GLASER, TALITA; ANDREJEW, ROBERTA; OLIVEIRA-GIACOMELLI, AGATHA; RIBEIRO, DEIDIANE ELISA; MARQUES, LUCAS BONFIM; YE, QING; REN, WEN-JING; SEMYANOV, ALEXEY; ILLES, PETER; TANG, YONG; et al. Purinergic Receptors in Basal Ganglia Diseases: Shared Molecular Mechanisms between Huntington's and Parkinson's Disease. NEUROSCIENCE BULLETIN, v. 36, n. 11, SI, p. 1299-1314, . (18/17504-5, 19/24553-5, 15/13345-1, 19/26852-0, 18/07366-4)
PALMA, TAIS VIDAL; BIANCHIN, NATHIELE BOTARI; DE OLIVEIRA, JULIANA SORRAILA; ASSMANN, CHARLES ELIAS; DAS NEVES OLIVEIRA, MONA; SCHETINGER, MARIA ROSA CHITOLINA; MORSCH, VERA MARIA; ULRICH, HENNING; PILLAT, MICHELI MAINARDI; DE ANDRADE, CINTHIA MELAZZO. erberine increases the expression of cytokines and proteins linked to apoptosis in human melanoma cell. MOLECULAR BIOLOGY REPORTS, v. 49, n. 3, . (18/07366-4)
MACHADO, RAFAEL R. G.; GLASER, TALITA; ARAUJO, DANIELLE B.; PETIZ, LYVIA LINTZMAIER; OLIVEIRA, DANIELLE B. L.; DURIGON, GIULIANA S.; LEAL, ALESSANDRA L.; PINHO, JOAO RENATO R.; FERREIRA, LUIS C. S.; ULRICH, HENNING; et al. Inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 Replication by Hypertonic Saline Solution in Lung and Kidney Epithelial Cells. ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE, v. 4, n. 5, p. 1514-1527, . (20/06409-1, 19/00195-2, 18/07366-4, 17/24769-2, 16/20045-7, 20/04680-0)
RIBEIRO, DEIDIANE ELISA; OLIVEIRA-GIACOMELLI, AGATHA; GLASER, TALITA; ARNAUD-SAMPAIO, VANESSA F.; ANDREJEW, ROBERTA; DIECKMANN, LUIZ; BARANOVA, JULIANA; LAMEU, CLAUDIANA; RATAJCZAK, MARIUSZ Z.; ULRICH, HENNING. Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology. MOLECULAR PSYCHIATRY, v. 26, n. 4, . (18/17504-5, 19/24553-5, 15/19128-2, 15/13345-1, 19/26852-0, 18/07366-4)
TRUJILLO, CLEBER A.; ADAMS, JASON W.; NEGRAES, PRISCILLA D.; CARROMEU, CASSIANO; TEJWANI, LEON; ACAB, ALLAN; TSUDA, BEN; THOMAS, CHARLES A.; SODHI, NEHA; FICHTER, KATHERINE M.; et al. Pharmacological reversal of synaptic and network pathology in human MECP2-KO neurons and cortical organoids. EMBO MOLECULAR MEDICINE, v. 13, n. 1, . (18/07366-4)
ADAMIAK, MATEUSZ; BUJKO, KAMILA; THAPA, ARJUN; PENSATO, VALENTINA; BRZEZNIAKIEWICZ-JANUS, KATARZYNA; RATAJCZAK, JANINA; DAVIES, DARYL L.; ULRICH, HENNING; KUCIA, MAGDA; RATAJCZAK, MARIUSZ Z.. The P2X4 purinergic receptor has emerged as a potent regulator of hematopoietic stem/progenitor cell mobilization and homing-a novel view of P2X4 and P2X7 receptor interaction in orchestrating stem cell trafficking. LEUKEMIA, v. 36, n. 1, . (18/07366-4)
CAO, XIN; YIN, HAI-YAN; ULRICH, HENNING; SEMYANOV, ALEXEY; TANG, YONG. A Neural Circuit for Gut-Induced Sugar Preference. NEUROSCIENCE BULLETIN, v. 37, n. 5, p. 754-756, . (18/07366-4)
GLASER, TALITA; SHIMOJO, HIROMI; RIBEIRO, DEIDIANE ELISA; MARTINS, PATRICIA PEREIRA LOPES; BECO, RENATA PEREIRA; KOSINSKI, MICHAL; SAMPAIO, VANESSA FERNANDES ARNAUD; CORREA-VELLOSO, JULIANA; OLIVEIRA-GIACOMELLI, AGATHA; LAMEU, CLAUDIANA; et al. ATP and spontaneous calcium oscillations control neural stem cell fate determination in Huntington's disease: a novel approach for cell clock research. MOLECULAR PSYCHIATRY, v. 26, n. 6, p. 2633-2650, . (18/07366-4, 15/13345-1, 12/50880-4)
FERNANDES FERREIRA, ANA FLAVIA; SINGULANI, MONIQUE PATRICIO; ULRICH, HENNING; FENG, ZHONG-PING; SUN, HONG-SHUO; BRITTO, LUIZ ROBERTO. Inhibition of TRPM2 by AG490 Is Neuroprotective in a Parkinson's Disease Animal Model. Molecular Neurobiology, . (18/07366-4, 20/02109-3)
CAMPOS, HENRIQUE C.; RIBEIRO, DEIDIANE ELISA; HASHIGUCHI, DEBORA; HUKUDA, DEBORAH Y.; GIMENES, CHRISTIANE; ROMARIZ, SIMONE A. A.; YE, QING; TANG, YONG; ULRICH, HENNING; LONGO, BEATRIZ MONTEIRO. Distinct Effects of the Hippocampal Transplantation of Neural and Mesenchymal Stem Cells in a Transgenic Model of Alzheimer's Disease. STEM CELL REVIEWS AND REPORTS, . (17/12412-2, 18/07366-4)
RABELO, IZADORA LORRANY ALVES; ARNAUD-SAMPAIO, VANESSA FERNANDES; ADINOLFI, ELENA; ULRICH, HENNING; LAMEU, CLAUDIANA. Cancer Metabostemness and Metabolic Reprogramming via P2X7 Receptor. CELLS, v. 10, n. 7, . (17/06132-7, 15/19128-2, 18/07366-4)
PEREZ, REBECA; BURGOS, VIVIANA; MARIN, VICTOR; CAMINS, ANTONI; OLLOQUEQUI, JORDI; GONZALEZ-CHAVARRIA, IVAN; ULRICH, HENNING; WYNEKE, URSULA; LUARTE, ALEJANDRO; ORTIZ, LEANDRO; et al. Caffeic Acid Phenethyl Ester (CAPE): Biosynthesis, Derivatives and Formulations with Neuroprotective Activities. ANTIOXIDANTS, v. 12, n. 8, p. 20-pg., . (18/07366-4)
DUARTE-SILVA, EDUARDO; ULRICH, HENNING; OLIVEIRA-GIACOMELLI, AGATHA; HARTUNG, HANS-PETER; MEUTH, SVEN G.; PEIXOTO, CHRISTINA ALVES. The adenosinergic signaling in the pathogenesis and treatment of multiple sclerosis. FRONTIERS IN IMMUNOLOGY, v. 13, p. 10-pg., . (18/07366-4, 18/08426-0, 19/26852-0)
RIBEIRO, DEIDIANE ELISA; PETIZ, LYVIA LINTZMAIER; GLASER, TALITA; OLIVEIRA-GIACOMELLI, AGATHA; ANDREJEW, ROBERTA; SAAB, FERNANDO DE AZEVEDO RIBEIRO; MILANIS, MILENA DA SILVA; CAMPOS, HENRIQUE CORREIA; SAMPAIO, VANESSA FERNANDES ARNAUD; LA BANCA, SOPHIA; et al. Purinergic signaling in cognitive impairment and neuropsychiatric symptoms of Alzheimer's disease. Neuropharmacology, v. 226, p. 16-pg., . (18/07366-4, 18/08426-0, 18/17504-5, 15/19128-2)
SANTOS, ANDERSON K.; SCALZO, SERGIO; DE SOUZA, RAYSA T. V.; SANTANA, PEDRO H. G.; MARQUES, BRUNO L.; OLIVEIRA, LUCAS F.; FILHO DANIEL, M.; KIHARA, ALEXANDRE HIROAKI; SANTIAGO, HELTON DA COSTA; PARREIRA, RICARDO C.; et al. Strategic use of organoids and organs-on-chip as biomimetic tools. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, v. 144, p. 8-pg., . (18/07366-4, 20/11667-0, 12/50880-4)
COUTINHO, FERNANDA; GUIMARAES, LARA M. F.; SEEGER, RODRIGO; SANTOS, ANA PAULA J.; GLASER, TALITA; YAMAMOTO, DENISE; LACERDA, LUCAS; ARNAUD-SAMPAIO, VANESSA; ROSSINI, CAIO V. T.; RABELO, IZADORA; et al. Bj-PRO-10c, as an allosteric regulator of argininosuccinate synthase, is a potential therapy for neuroblastoma metastasis. Toxicon, v. 233, p. 9-pg., . (13/07937-8, 16/11098-0, 18/18799-9, 19/17483-0, 15/19128-2, 22/11093-9, 19/08999-3, 18/07366-4)
ILLES, PETER; ULRICH, HENNING; CHEN, JIANG-FAN; TANG, YONG. Purinergic receptors in cognitive disturbances. Neurobiology of Disease, v. 185, p. 16-pg., . (18/07366-4)
HIGA, GUILHERME SHIGUETO VILAR; FRANCIS-OLIVEIRA, JOSE; CARLOS-LIMA, ESTEVAO; TAMAIS, ALICIA MORAES; BORGES, FERNANDO DA SILVA; KIHARA, ALEXANDRE HIROAKI; SHIEH, IANE CARVALHO; ULRICH, HENNING; CHIAVEGATTO, SILVANA; DE PASQUALE, ROBERTO. 5-HT-dependent synaptic plasticity of the prefrontal cortex in postnatal development. SCIENTIFIC REPORTS, v. 12, n. 1, p. 23-pg., . (19/21233-0, 17/06100-8, 16/09116-0, 22/00850-3, 16/25840-0, 17/20253-1, 18/07366-4, 19/14962-5)
GLASER, TALITA; ANDREJEW, ROBERTA; OLIVEIRA-GIACOMELLI, AGATHA; RIBEIRO, DEIDIANE ELISA; MARQUES, LUCAS BONFIM; YE, QING; REN, WEN-JING; SEMYANOV, ALEXEY; ILLES, PETER; TANG, YONG; et al. Purinergic Receptors in Basal Ganglia Diseases: Shared Molecular Mechanisms between Huntington's and Parkinson's Disease. NEUROSCIENCE BULLETIN, v. 36, n. 11, p. 16-pg., . (18/17504-5, 19/24553-5, 15/13345-1, 19/26852-0, 18/07366-4)
REN, WEN-JING; ULRICH, HENNING; SEMYANOV, ALEXEY; ILLES, PETER; TANG, YONG. TASK-3: New Target for Pain-Relief. NEUROSCIENCE BULLETIN, v. 36, n. 8, p. 4-pg., . (18/07366-4)
VILLEGAS, CECILIA; PEREZ, REBECA; PETIZ, LYVIA LINTZMAIER; GLASER, TALITA; ULRICH, HENNING; PAZ, CRISTIAN. Ginkgolides and Huperzine A for complementary treatment of Alzheimer's disease. IUBMB Life, v. 74, n. 8, p. 17-pg., . (18/08426-0, 18/07366-4, 21/00060-0)
ALAVARSE, ALEX CARVALHO; FRACHINI, EMILLI CAROLINE G.; SILVA, JEAN BEZERRA; PEREIRA, RAFAEL DOS SANTOS; ULRICH, HENNING; SIQUEIRA PETRI, DENISE FREITAS. Amino acid decorated xanthan gum coatings: Molecular arrangement and cell adhesion. CARBOHYDRATE POLYMER TECHNOLOGIES AND APPLICATIONS, v. 4, p. 11-pg., . (20/01907-3, 18/07366-4, 18/13492-2)
PETIZ, LYVIA LINTZMAIER; GLASER, TALITA; SCHARFSTEIN, JULIO; RATAJCZAK, MARIUSZ Z.; ULRICH, HENNING. P2Y14 Receptor as a Target for Neutrophilia Attenuation in Severe COVID-19 Cases: From Hematopoietic Stem Cell Recruitment and Chemotaxis to Thrombo-inflammation. STEM CELL REVIEWS AND REPORTS, v. 17, n. 1, p. 12-pg., . (18/07366-4, 15/13345-1)
DE OLIVEIRA, LUCAS FELIPE; MENDES FILHO, DANIEL; MARQUES, BRUNO LEMES; MACIEL, GIOVANA FIGUEIREDO; PARREIRA, RICARDO CAMBRAIA; NETO, JOSE RODRIGUES DO CARMO; DA SILVA, PRISCILLA ELIAS FERREIRA; GUERRA, RHANOICA OLIVEIRA; DA SILVA, MARCOS VINICIUS; SANTIAGO, HELTON DA COSTA; et al. Organoids as a novel tool in modelling infectious diseases. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, v. 144, p. 10-pg., . (18/07366-4, 20/11667-0)
CAMPOS, HENRIQUE CORREIA; RIBEIRO, DEIDIANE ELISA; HASHIGUCHI, DEBORA; GLASER, TALITA; MILANIS, MILENA DA SILVA; GIMENES, CHRISTIANE; SUCHECKI, DEBORAH; ARIDA, RICARDO MARIO; ULRICH, HENNING; MONTEIRO LONGO, BEATRIZ. Neuroprotective effects of resistance physical exercise on the APP/PS1 mouse model of Alzheimer's disease. FRONTIERS IN NEUROSCIENCE, v. 17, p. 11-pg., . (18/07366-4, 22/00249-8, 18/17504-5, 21/01478-8)
FRACHINI, EMILLI C. G.; SELVA, JESSICA S. G.; FALCOSWKI, PAULA C.; SILVA, JEAN B.; CORNEJO, DANIEL R.; BERTOTTI, MAURO; ULRICH, HENNING; PETRI, DENISE F. S.. Caffeine Release from Magneto-Responsive Hydrogels Controlled by External Magnetic Field and Calcium Ions and Its Effect on the Viability of Neuronal Cells. POLYMERS, v. 15, n. 7, p. 22-pg., . (18/13492-2, 18/07366-4, 18/08782-1)
FRANCZAK, STEPHANIE; ULRICH, HENNING; RATAJCZAK, MARIUSZ Z. Z.. Hematopoietic stem cells on the crossroad between purinergic signaling and innate immunity. PURINERGIC SIGNALLING, v. N/A, p. 7-pg., . (18/07366-4)
PIETROBON, ANNA JULIA; ANDREJEW, ROBERTA; CUSTODIO, RICARDO WESLEY ALBERCA; OLIVEIRA, LUANA DE MENDONCA; SCHOLL, JULIETE NATHALI; TEIXEIRA, FRANCIANE MOURADIAN EMIDIO; DE BRITO, CYRO ALVES; GLASER, TALITA; KAZMIERSKI, JULIA; GOFFINET, CHRISTINE; et al. Dysfunctional purinergic signaling correlates with disease severity in COVID-19 patients. FRONTIERS IN IMMUNOLOGY, v. 13, p. 12-pg., . (18/07366-4, 20/13148-0)
GONCALVES, MARIA CAROLINA BITTENCOURT; GLASER, TALITA; OLIVEIRA, SOPHIA LA BANCA DE; ULRICH, HENNING. Adenosinergic-Dopaminergic Signaling in Mood Disorders: A Mini-Review. JOURNAL OF CAFFEINE AND ADENOSINE RESEARCH, v. 10, n. 3, p. 10-pg., . (18/07366-4, 15/13345-1)
WANG, TAO; ULRICH, HENNING; SEMYANOV, ALEXEY; ILLES, PETER; TANG, YONG. Optical control of purinergic signaling. PURINERGIC SIGNALLING, v. 17, n. 3, p. 385-392, . (18/07366-4)
PETIZ, LYVIA LINTZMAIER; GLASER, TALITA; SCHARFSTEIN, JULIO; RATAJCZAK, MARIUSZ Z.; ULRICH, HENNING. P2Y14 Receptor as a Target for Neutrophilia Attenuation in Severe COVID-19 Cases: From Hematopoietic Stem Cell Recruitment and Chemotaxis to Thrombo-inflammation. STEM CELL REVIEWS AND REPORTS, v. 17, n. 1, SI, . (18/07366-4, 15/13345-1)
TROMBETTA-LIMA, MARINA; ASSIS-RIBAS, THAIS; CINTRA, RICARDO C.; CAMPEIRO, JOANA D.; GUERREIRO, JULIANO R.; WINNISCHOFER, SHEILA M. B.; NASCIMENTO, ISIS C. C.; ULRICH, HENNING; HAYASHI, MIRIAN A. F.; SOGAYAR, MARI C.. Impact of Reck expression and promoter activity in neuronal in vitro differentiation. MOLECULAR BIOLOGY REPORTS, v. 48, n. 2, . (18/20014-0, 16/05311-2, 18/07366-4, 14/50891-1, 19/13112-8, 15/26328-8, 16/18277-7, 12/50880-4, 17/02413-1)
BOTTARI, NATHIELI B.; REICHERT, KARINE PAULA; FRACASSO, MATEUS; DUTRA, ANIELEN; ASSMANN, CHARLES ELIAS; ULRICH, HENNING; CHITOLINA SCHETINGER, MARIA ROSA; MORSCH, VERA M.; DA SILVA, ALEKSANDRO SCHAFER. Neuroprotective role of resveratrol mediated by purinergic signalling in cerebral cortex of mice infected byToxoplasma gondii. Parasitology Research, v. 119, n. 9, . (18/07366-4)
ARNAUD-SAMPAIO, VANESSA F.; RABELO, IZADORA L. A.; BENTO, CAROLINA A.; GLASER, TALITA; BEZERRA, JEAN; COUTINHO-SILVA, ROBSON; ULRICH, HENNING; LAMEU, CLAUDIANA. Using Cytometry for Investigation of Purinergic Signaling in Tumor-Associated Macrophages. Cytometry Part A, v. 97, n. 11, . (17/06132-7, 15/13345-1, 18/07366-4, 18/14993-5, 15/19128-2)
KRUGER, ARNE; DE JESUS SANTOS, ANA PAULA; DE SA, VANESSA; ULRICH, HENNING; WRENGER, CARSTEN. Aptamer Applications in Emerging Viral Diseases. PHARMACEUTICALS, v. 14, n. 7, . (18/07366-4, 15/26722-8, 17/03966-4, 15/26642-4)
DE SOUZA, ANACLETO SILVA; DE FREITAS AMORIM, VITOR MARTINS; GUARDIA, GABRIELA D. A.; DOS SANTOS, FILIPE F.; ULRICH, HENNING; GALANTE, PEDRO A. F.; DE SOUZA, ROBSON FRANCISCO; GUZZO, CRISTIANE RODRIGUES. Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern: A Perspective for Emerging More Transmissible and Vaccine-Resistant Strains. Viruses-Basel, v. 14, n. 4, p. 21-pg., . (18/07366-4, 20/06091-1, 19/00195-2, 16/09047-8, 20/14158-9, 20/04680-0, 17/18246-7, 17/19541-2, 18/15579-8)
TOMCZYK, MARTA; GLASER, TALITA; SLOMINSKA, EWA M.; ULRICH, HENNING; SMOLENSKI, RYSZARD T.. Purine Nucleotides Metabolism and Signaling in Huntington's Disease: Search for a Target for Novel Therapies. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 22, n. 12, . (18/07366-4)
WANG, TAO; ULRICH, HENNING; SEMYANOV, ALEXEY; ILLES, PETER; TANG, YONG. Optical control of purinergic signaling. PURINERGIC SIGNALLING, . (18/07366-4)
CORREA-VELLOSO, JULIANA C.; BARTLETT, PAULA J.; BRUMER, ROBERT; GASPERS, LAWRENCE D.; ULRICH, HENNING; THOMAS, ANDREW P.. Receptor-specific Ca2+ oscillation patterns mediated by differential regulation of P2Y purinergic receptors in rat hepatocytes. ISCIENCE, v. 24, n. 10, . (18/07366-4)
ANDREJEW, ROBERTA; OLIVEIRA-GIACOMELLI, AGATHA; RIBEIRO, DEIDIANE ELISA; GLASER, TALITA; ARNAUD-SAMPAIO, VANESSA FERNANDES; LAMEU, CLAUDIANA; ULRICH, HENNING. The P2X7 Receptor: Central Hub of Brain Diseases. FRONTIERS IN MOLECULAR NEUROSCIENCE, v. 13, . (15/13345-1, 18/17504-5, 19/24553-5, 15/19128-2, 18/07366-4)
PILLAT, MICHELI MAINARDI; KRUGER, ARNE; FERREIRA GUIMARAES, LARA MENDES; LAMEU, CLAUDIANA; DE SOUZA, EDMARCIA ELISA; WRENGER, CARSTEN; ULRICH, HENNING. Insights in Chloroquine Action: Perspectives and Implications in Malaria andCOVID-19. Cytometry Part A, v. 97, n. 9, . (18/07366-4, 18/08820-0, 15/26722-8, 15/19128-2)
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ARNAUD-SAMPAIO, VANESSA FERNANDES; ALVES RABELO, IZADORA LORRANY; ULRICH, HENNING; LAMEU, CLAUDIANA. The P2X7 Receptor in the Maintenance of Cancer Stem Cells, Chemoresistance and Metastasis. STEM CELL REVIEWS AND REPORTS, v. 16, n. 2, p. 288-300, . (15/19128-2, 18/07366-4, 17/06132-7)
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