Purine and kinin receptors as targets of study and therapeutic interventions in neurological diseases

• Grant number: 18/07366-4
• Support Opportunities: Research Projects - Thematic Grants
• Start date: April 01, 2019
• End date: March 31, 2025
• Field of knowledge: Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
• Principal Investigator: Alexander Henning Ulrich
• Grantee: Alexander Henning Ulrich
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Pesquisadores principais:( Últimos ): Luiz Roberto Giorgetti de Britto
• Pesquisadores principais:( Antigos ): Marimélia Aparecida Porcionatto
• Associated researchers: Beatriz de Oliveira Monteiro ; Claudiana Lameu ; Cristiane Otero Reis Salum ; João Bosco Pesquero ; Luiz Henrique Catalani ; Marimélia Aparecida Porcionatto ; Mayana Zatz ; Roberto De Pasquale ; Roberto Kopke Salinas ; Silvana Chiavegatto
• Associated scholarship(s): 24/17387-0 - The role of P2X7 and P2Y12 purinergic receptors in the neurodevelopment of autism spectrum disorders and Alzheimer's Disease: Integration of brain organoid and mouse models., BP.PD; 24/17556-6 - Role of purinergic receptors in an animal model of hippocampal immaturity, BP.DD; 24/17748-2 - Assessment of social behavior in a murine model of hippocampal immaturity, BP.IC; + associated scholarships 24/04616-0 - Inhibition of the P2X7 purinergic receptor in microglia-mediated neuroinflammation in the in vivo model of Alzheimer's disease and its possible correlation with GSK3, BP.IC; 24/04690-6 - The effect of caffeine and purinergic signaling in three-dimensional models of Alzheimer's Disease using bioprinting, BP.PD; 23/09308-0 - In vitro evaluation of the modulation of purinergic receptors P2Y6, P2Y12, and P2X7 in a microglial cell line, BP.IC; 23/06673-9 - Role of purinergic receptors and huntingtin in gastrulation., BP.TT; 23/04077-0 - Study of the co-morbidity of Bipolar Disorder and Alzheimer's Disease using 3D cultures of decellularized brain matrices., BP.TT; 22/10950-5 - Selection and evaluation of proteins and fundamental mechanisms for the formation of long-term memory, BP.DD; 22/09277-4 - Hippocampal pathological plasticity in neonatal anoxia, BP.PD; 22/10616-8 - Assessment of spatial memory, cognition and learning in a murine model of hippocampal immaturity, BP.IC; 22/12888-5 - Role of the P2X7 purinergic receptor in microglia-mediated neurotoxicity in models of Alzheimer's disease and its possible correlation with the modulation of neurogenesis, BP.IC; 22/01304-2 - In vitro studies of the role of P2X4 receptors on inflammatory processes involved in Parkinsons Disease, BP.MS; 21/01478-8 - Molecular effects of pharmacological modulation of P2Y6 receptors in an in vitro model for the study of Alzheimer's Disease, BP.MS; 21/04769-3 - Purinergic signaling mediated by exosomes in the plasticity of the tumor microenvironment and chemoresistance of Neuroblastoma, BP.DD; 21/00060-0 - Role of P2Y14 receptor modulation in the hippocampal neuroinflammatory responses in in vitro and in vivo models of Alzheimer's Disease, BP.PD; 21/05279-0 - The role of purinergic receptors and Huntingtin in gastrulation, BP.TT; 21/04174-0 - Study of the bipolar disorder and Alzheimer's disease comorbidity using 3D cultures of decellularized brain extracellular matrix, BP.TT; 20/10725-6 - Evaluation of purinergic receptors in the comorbidity of bipolar disorder and Alzheimer's Disease, BP.DD; 20/07609-4 - Study of the neuroregeneration process triggered by bradykinin in the animal model of Parkinson's Disease, BP.IC; 19/24553-5 - The role of P2Y1 receptor in Parkinsons Disease, BP.DR; 19/26852-0 - Study of purinergic receptors antagonism in the inflammatory process and microglial cells activation using in vitro and in vivo models of Parkinsons Disease, BP.PD; 18/17504-5 - Behavioral and molecular effects of pharmacological modulation of the P2Y2 receptors in an animal model of Alzheimer's Disease, BP.PD; 19/03494-0 - Silencing of B1R and B2R kinin receptors in the BV-2 microglial cell line as a model of neuroinflammation response, BP.IC; 15/15826-7 - Collagen hydrogel modified by bi-functional recombinant protein for transplantation of neural stem cells for the treatment of neurodegenerative disorder, BP.PD; 15/19478-3 - Role of kinin-B2 receptor in pathogenesis and progression of familial Alzheimer's Disease: from neurogenesis and immune response to cognition, BP.PD; 15/13345-1 - Huntington's disease: Huntingtin roles during cell fate decision, BP.PD - associated scholarships

Abstract

The biological process of neurogenesis that consists of differentiation of neural stem cells (NSC) into neurons, occurs both in embryonic and adult phases. Therefore, NSC are being proposed as interesting tools for nervous system tissue regeneration and restoration of physiological conditions, as well as models for elucidation of pathophysiological development of neurological diseases. Previous studies of our laboratory showed several signalling pathways involved in NSC development, especially through purinergic and kininergic receptors, whose modulation is essential in neural phenotype determination. Besides participating in adult brain neurotransmition in health conditions, their modulation reverted pathologic scenarios in animal and in vitro models of Parkinson's and Alzheimer's Disease. Taking into account these findings of our group, we proposed here a more profound investigation regarding mechanisms underlying in these effects, elucidating how purinergic and kininergic systems are involved and potential therapeutic targets for neurologic pathologies, especially associated with neurodegeneration/ regeneration and inflammatory process. Thus, the neurogenic, neuroprotective and immunomodulatory effects of purinergic and kininergic signalling will be studied in Parkinson's, Alzheimer's and Huntington's diseases and in bipolar disorder. Moreover, new tools based on nanotechnology, as biopolymers conjugated to bradikinin, will be used in NSC transplantation improvement as therapeutic alternative in animal models. (AU)

Scientific publications

(85)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GLASER, TALITA; ANDREJEW, ROBERTA; OLIVEIRA-GIACOMELLI, AGATHA; RIBEIRO, DEIDIANE ELISA; MARQUES, LUCAS BONFIM; YE, QING; REN, WEN-JING; SEMYANOV, ALEXEY; ILLES, PETER; TANG, YONG; et al. Purinergic Receptors in Basal Ganglia Diseases: Shared Molecular Mechanisms between Huntington's and Parkinson's Disease. NEUROSCIENCE BULLETIN, v. 36, n. 11, SI, p. 1299-1314, NOV 2020. (18/17504-5, 19/24553-5, 15/13345-1, 19/26852-0, 18/07366-4)

PETIZ, LYVIA LINTZMAIER; GLASER, TALITA; SCHARFSTEIN, JULIO; RATAJCZAK, MARIUSZ Z.; ULRICH, HENNING. P2Y14 Receptor as a Target for Neutrophilia Attenuation in Severe COVID-19 Cases: From Hematopoietic Stem Cell Recruitment and Chemotaxis to Thrombo-inflammation. STEM CELL REVIEWS AND REPORTS, v. 17, n. 1, SI, FEB 2021. (18/07366-4, 15/13345-1)

BOTTARI, NATHIELI B.; REICHERT, KARINE PAULA; FRACASSO, MATEUS; DUTRA, ANIELEN; ASSMANN, CHARLES ELIAS; ULRICH, HENNING; CHITOLINA SCHETINGER, MARIA ROSA; MORSCH, VERA M.; DA SILVA, ALEKSANDRO SCHAFER. Neuroprotective role of resveratrol mediated by purinergic signalling in cerebral cortex of mice infected byToxoplasma gondii. Parasitology Research, v. 119, n. 9, JUL 2020. (18/07366-4)

CAO, XIN; YIN, HAI-YAN; ULRICH, HENNING; SEMYANOV, ALEXEY; TANG, YONG. A Neural Circuit for Gut-Induced Sugar Preference. NEUROSCIENCE BULLETIN, v. 37, n. 5, p. 754-756, MAY 2021. (18/07366-4)

RIBEIRO, DEIDIANE ELISA; OLIVEIRA-GIACOMELLI, AGATHA; GLASER, TALITA; ARNAUD-SAMPAIO, VANESSA F.; ANDREJEW, ROBERTA; DIECKMANN, LUIZ; BARANOVA, JULIANA; LAMEU, CLAUDIANA; RATAJCZAK, MARIUSZ Z.; ULRICH, HENNING. Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology. MOLECULAR PSYCHIATRY, v. 26, n. 4, DEC 2020. (18/17504-5, 19/24553-5, 15/19128-2, 15/13345-1, 19/26852-0, 18/07366-4)

TRUJILLO, CLEBER A.; ADAMS, JASON W.; NEGRAES, PRISCILLA D.; CARROMEU, CASSIANO; TEJWANI, LEON; ACAB, ALLAN; TSUDA, BEN; THOMAS, CHARLES A.; SODHI, NEHA; FICHTER, KATHERINE M.; et al. Pharmacological reversal of synaptic and network pathology in human MECP2-KO neurons and cortical organoids. EMBO MOLECULAR MEDICINE, v. 13, n. 1, DEC 2020. (18/07366-4)

RATAJCZAK, MARIUSZ Z.; ADAMIAK, MATEUSZ; BUJKO, KAMILA; THAPA, ARJUN; PENSATO, VALENTINA; KUCIA, MAGDA; RATAJCZAK, JANINA; ULRICH, HENNING. Innate immunity orchestrates the mobilization and homing of hematopoietic stem/progenitor cells by engaging purinergic signaling-an update. PURINERGIC SIGNALLING, MAY 2020. (18/07366-4)

PALMA, TAIS VIDAL; LENZ, LUANA SUELING; BOTTARI, NATHIELE BIANCHIN; PEREIRA, ALINE; SCHETINGER, MARIA ROSA CHITOLINA; MORSCH, VERA MARIA; ULRICH, HENNING; PILLAT, MICHELI MAINARDI; DE ANDRADE, CINTHIA MELAZZO. Berberine induces apoptosis in glioblastoma multiforme U87MG cells via oxidative stress and independent of AMPK activity. MOLECULAR BIOLOGY REPORTS, v. 47, n. 6, MAY 2020. (18/07366-4)

PIETROBON, ANNA JULIA; ANDREJEW, ROBERTA; CUSTODIO, RICARDO WESLEY ALBERCA; OLIVEIRA, LUANA DE MENDONCA; SCHOLL, JULIETE NATHALI; TEIXEIRA, FRANCIANE MOURADIAN EMIDIO; DE BRITO, CYRO ALVES; GLASER, TALITA; KAZMIERSKI, JULIA; GOFFINET, CHRISTINE; et al. Dysfunctional purinergic signaling correlates with disease severity in COVID-19 patients. FRONTIERS IN IMMUNOLOGY, v. 13, p. 12-pg., 2022-09-30. (18/07366-4, 20/13148-0)

RABELO, IZADORA LORRANY ALVES; ARNAUD-SAMPAIO, VANESSA FERNANDES; ADINOLFI, ELENA; ULRICH, HENNING; LAMEU, CLAUDIANA. Cancer Metabostemness and Metabolic Reprogramming via P2X7 Receptor. CELLS, v. 10, n. 7, JUL 2021. (17/06132-7, 15/19128-2, 18/07366-4)

ADAMIAK, MATEUSZ; BUJKO, KAMILA; THAPA, ARJUN; PENSATO, VALENTINA; BRZEZNIAKIEWICZ-JANUS, KATARZYNA; RATAJCZAK, JANINA; DAVIES, DARYL L.; ULRICH, HENNING; KUCIA, MAGDA; RATAJCZAK, MARIUSZ Z.. The P2X4 purinergic receptor has emerged as a potent regulator of hematopoietic stem/progenitor cell mobilization and homing-a novel view of P2X4 and P2X7 receptor interaction in orchestrating stem cell trafficking. LEUKEMIA, v. 36, n. 1, JUL 2021. (18/07366-4)

FERNANDES FERREIRA, ANA FLAVIA; SINGULANI, MONIQUE PATRICIO; ULRICH, HENNING; FENG, ZHONG-PING; SUN, HONG-SHUO; BRITTO, LUIZ ROBERTO. Inhibition of TRPM2 by AG490 Is Neuroprotective in a Parkinson's Disease Animal Model. Molecular Neurobiology, JAN 2022. (18/07366-4, 20/02109-3)

CAMPOS, HENRIQUE C.; RIBEIRO, DEIDIANE ELISA; HASHIGUCHI, DEBORA; HUKUDA, DEBORAH Y.; GIMENES, CHRISTIANE; ROMARIZ, SIMONE A. A.; YE, QING; TANG, YONG; ULRICH, HENNING; LONGO, BEATRIZ MONTEIRO. Distinct Effects of the Hippocampal Transplantation of Neural and Mesenchymal Stem Cells in a Transgenic Model of Alzheimer's Disease. STEM CELL REVIEWS AND REPORTS, JAN 2022. (17/12412-2, 18/07366-4)

GONCALVES, MARIA CAROLINA BITTENCOURT; GLASER, TALITA; OLIVEIRA, SOPHIA LA BANCA DE; ULRICH, HENNING. Adenosinergic-Dopaminergic Signaling in Mood Disorders: A Mini-Review. JOURNAL OF CAFFEINE AND ADENOSINE RESEARCH, v. 10, n. 3, p. 10-pg., 2020-09-01. (18/07366-4, 15/13345-1)

JUVENAL, GUILHERME; MEINERZ, CARINE; AYUPE, ANA CAROLINA; CAMPOS, HENRIQUE CORREIA; REIS, EDUARDO MORAES; LONGO, BEATRIZ MONTEIRO; PILLAT, MICHELI MAINARDI; ULRICH, HENNING. Bradykinin promotes immune responses in differentiated embryonic neurospheres carrying APP^swe and PS1^dE9 mutations. CELL AND BIOSCIENCE, v. 14, n. 1, p. 19-pg., 2024-06-18. (18/07366-4, 22/10950-5)

GLASER, TALITA; ANDREJEW, ROBERTA; OLIVEIRA-GIACOMELLI, AGATHA; RIBEIRO, DEIDIANE ELISA; MARQUES, LUCAS BONFIM; YE, QING; REN, WEN-JING; SEMYANOV, ALEXEY; ILLES, PETER; TANG, YONG; et al. Purinergic Receptors in Basal Ganglia Diseases: Shared Molecular Mechanisms between Huntington's and Parkinson's Disease. NEUROSCIENCE BULLETIN, v. 36, n. 11, p. 16-pg., 2020-10-07. (18/17504-5, 19/24553-5, 15/13345-1, 19/26852-0, 18/07366-4)

REN, WEN-JING; ULRICH, HENNING; SEMYANOV, ALEXEY; ILLES, PETER; TANG, YONG. TASK-3: New Target for Pain-Relief. NEUROSCIENCE BULLETIN, v. 36, n. 8, p. 4-pg., 2020-05-26. (18/07366-4)

BENTO, CAROLINA ADRIANE; ARNAUD-SAMPAIO, VANESSA FERNANDES; GLASER, TALITA; ADINOLFI, ELENA; COUTINHO-SILVA, ROBSON; ULRICH, HENNING; LAMEU, CLAUDIANA. P2X7 receptor in macrophage polarization and its implications in neuroblastoma tumor behavior. PURINERGIC SIGNALLING, v. N/A, p. 18-pg., 2024-10-19. (18/14993-5, 22/11093-9, 18/07366-4, 15/19128-2)

ULRICH, HENNING; GLASER, TALITA; THOMAS, ANDREW P.. Purinergic signaling in liver disease: calcium signaling and induction of inflammation. PURINERGIC SIGNALLING, v. N/A, p. 13-pg., 2024-09-25. (18/07366-4)

FRANCIS-OLIVEIRA, JOSE; HIGA, GUILHERME SHIGUETO VILAR; VIANA, FELIPE JOSE COSTA; CRUVINEL, EMILY; CARLOS-LIMA, ESTEVAO; BORGES, FERNANDO DA SILVA; ZAMPIERI, THAIS TESSARI; REBELLO, FERNANDA PEREIRA; ULRICH, HENNING; DE PASQUALE, ROBERTO. TREK-1 inhibition promotes synaptic plasticity in the prelimbic cortex. Experimental Neurology, v. 373, p. 20-pg., 2023-12-19. (22/00850-3, 22/09277-4, 16/09116-0, 18/07366-4, 16/25840-0)

PETIZ, LYVIA LINTZMAIER; GLASER, TALITA; SCHARFSTEIN, JULIO; RATAJCZAK, MARIUSZ Z.; ULRICH, HENNING. P2Y14 Receptor as a Target for Neutrophilia Attenuation in Severe COVID-19 Cases: From Hematopoietic Stem Cell Recruitment and Chemotaxis to Thrombo-inflammation. STEM CELL REVIEWS AND REPORTS, v. 17, n. 1, p. 12-pg., 2021-02-11. (18/07366-4, 15/13345-1)

DE OLIVEIRA, LUCAS FELIPE; MENDES FILHO, DANIEL; MARQUES, BRUNO LEMES; MACIEL, GIOVANA FIGUEIREDO; PARREIRA, RICARDO CAMBRAIA; NETO, JOSE RODRIGUES DO CARMO; DA SILVA, PRISCILLA ELIAS FERREIRA; GUERRA, RHANOICA OLIVEIRA; DA SILVA, MARCOS VINICIUS; SANTIAGO, HELTON DA COSTA; et al. Organoids as a novel tool in modelling infectious diseases. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, v. 144, p. 10-pg., 2023-03-17. (18/07366-4, 20/11667-0)

CAMPOS, HENRIQUE CORREIA; RIBEIRO, DEIDIANE ELISA; HASHIGUCHI, DEBORA; GLASER, TALITA; MILANIS, MILENA DA SILVA; GIMENES, CHRISTIANE; SUCHECKI, DEBORAH; ARIDA, RICARDO MARIO; ULRICH, HENNING; MONTEIRO LONGO, BEATRIZ. Neuroprotective effects of resistance physical exercise on the APP/PS1 mouse model of Alzheimer's disease. FRONTIERS IN NEUROSCIENCE, v. 17, p. 11-pg., 2023-04-06. (18/07366-4, 22/00249-8, 18/17504-5, 21/01478-8)

SANTOS, ANDERSON K.; SCALZO, SERGIO; DE SOUZA, RAYSA T. V.; SANTANA, PEDRO H. G.; MARQUES, BRUNO L.; OLIVEIRA, LUCAS F.; FILHO DANIEL, M.; KIHARA, ALEXANDRE HIROAKI; SANTIAGO, HELTON DA COSTA; PARREIRA, RICARDO C.; et al. Strategic use of organoids and organs-on-chip as biomimetic tools. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, v. 144, p. 8-pg., 2023-03-17. (18/07366-4, 20/11667-0, 12/50880-4)

COUTINHO, FERNANDA; GUIMARAES, LARA M. F.; SEEGER, RODRIGO; SANTOS, ANA PAULA J.; GLASER, TALITA; YAMAMOTO, DENISE; LACERDA, LUCAS; ARNAUD-SAMPAIO, VANESSA; ROSSINI, CAIO V. T.; RABELO, IZADORA; et al. Bj-PRO-10c, as an allosteric regulator of argininosuccinate synthase, is a potential therapy for neuroblastoma metastasis. Toxicon, v. 233, p. 9-pg., 2023-09-01. (13/07937-8, 16/11098-0, 18/18799-9, 19/17483-0, 15/19128-2, 22/11093-9, 19/08999-3, 18/07366-4)

ILLES, PETER; ULRICH, HENNING; CHEN, JIANG-FAN; TANG, YONG. Purinergic receptors in cognitive disturbances. Neurobiology of Disease, v. 185, p. 16-pg., 2023-09-01. (18/07366-4)

FRACHINI, EMILLI C. G.; SELVA, JESSICA S. G.; FALCOSWKI, PAULA C.; SILVA, JEAN B.; CORNEJO, DANIEL R.; BERTOTTI, MAURO; ULRICH, HENNING; PETRI, DENISE F. S.. Caffeine Release from Magneto-Responsive Hydrogels Controlled by External Magnetic Field and Calcium Ions and Its Effect on the Viability of Neuronal Cells. POLYMERS, v. 15, n. 7, p. 22-pg., 2023-04-01. (18/13492-2, 18/07366-4, 18/08782-1)

FRANCZAK, STEPHANIE; ULRICH, HENNING; RATAJCZAK, MARIUSZ Z. Z.. Hematopoietic stem cells on the crossroad between purinergic signaling and innate immunity. PURINERGIC SIGNALLING, v. N/A, p. 7-pg., 2023-05-15. (18/07366-4)

HUANG, ZHAO; XIE, NA; ILLES, PETER; DI VIRGILIO, FRANCESCO; ULRICH, HENNING; SEMYANOV, ALEXEY; VERKHRATSKY, ALEXEI; SPERLAGH, BEATA; YU, SHU-GUANG; HUANG, CANHUA; et al. From purines to purinergic signalling: molecular functions and human diseases. SIGNAL TRANSDUCTION AND TARGETED THERAPY, v. 6, n. 1, APR 28 2021. (18/07366-4)

MIRANDA, ALVARO; MONTIEL, ENRIQUE; ULRICH, HENNING; PAZ, CRISTIAN. Selective Secretase Targeting for Alzheimer's Disease Therapy. JOURNAL OF ALZHEIMER'S DISEASE, v. 81, n. 1, p. 1-17, 2021. (18/07366-4)

PALMA, TAIS VIDAL; BIANCHIN, NATHIELE BOTARI; DE OLIVEIRA, JULIANA SORRAILA; ASSMANN, CHARLES ELIAS; DAS NEVES OLIVEIRA, MONA; SCHETINGER, MARIA ROSA CHITOLINA; MORSCH, VERA MARIA; ULRICH, HENNING; PILLAT, MICHELI MAINARDI; DE ANDRADE, CINTHIA MELAZZO. erberine increases the expression of cytokines and proteins linked to apoptosis in human melanoma cell. MOLECULAR BIOLOGY REPORTS, v. 49, n. 3, DEC 2021. (18/07366-4)

GLASER, TALITA; SHIMOJO, HIROMI; RIBEIRO, DEIDIANE ELISA; MARTINS, PATRICIA PEREIRA LOPES; BECO, RENATA PEREIRA; KOSINSKI, MICHAL; SAMPAIO, VANESSA FERNANDES ARNAUD; CORREA-VELLOSO, JULIANA; OLIVEIRA-GIACOMELLI, AGATHA; LAMEU, CLAUDIANA; et al. ATP and spontaneous calcium oscillations control neural stem cell fate determination in Huntington's disease: a novel approach for cell clock research. MOLECULAR PSYCHIATRY, v. 26, n. 6, p. 2633-2650, JUN 2021. (18/07366-4, 15/13345-1, 12/50880-4)

ALAVARSE, ALEX CARVALHO; FRACHINI, EMILLI CAROLINE G.; SILVA, JEAN BEZERRA; PEREIRA, RAFAEL DOS SANTOS; ULRICH, HENNING; SIQUEIRA PETRI, DENISE FREITAS. Amino acid decorated xanthan gum coatings: Molecular arrangement and cell adhesion. CARBOHYDRATE POLYMER TECHNOLOGIES AND APPLICATIONS, v. 4, p. 11-pg., 2022-06-13. (20/01907-3, 18/07366-4, 18/13492-2)

PEREZ, REBECA; BURGOS, VIVIANA; MARIN, VICTOR; CAMINS, ANTONI; OLLOQUEQUI, JORDI; GONZALEZ-CHAVARRIA, IVAN; ULRICH, HENNING; WYNEKE, URSULA; LUARTE, ALEJANDRO; ORTIZ, LEANDRO; et al. Caffeic Acid Phenethyl Ester (CAPE): Biosynthesis, Derivatives and Formulations with Neuroprotective Activities. ANTIOXIDANTS, v. 12, n. 8, p. 20-pg., 2023-08-01. (18/07366-4)

DUARTE-SILVA, EDUARDO; ULRICH, HENNING; OLIVEIRA-GIACOMELLI, AGATHA; HARTUNG, HANS-PETER; MEUTH, SVEN G.; PEIXOTO, CHRISTINA ALVES. The adenosinergic signaling in the pathogenesis and treatment of multiple sclerosis. FRONTIERS IN IMMUNOLOGY, v. 13, p. 10-pg., 2022-07-28. (18/07366-4, 18/08426-0, 19/26852-0)

RIBEIRO, DEIDIANE ELISA; PETIZ, LYVIA LINTZMAIER; GLASER, TALITA; OLIVEIRA-GIACOMELLI, AGATHA; ANDREJEW, ROBERTA; SAAB, FERNANDO DE AZEVEDO RIBEIRO; MILANIS, MILENA DA SILVA; CAMPOS, HENRIQUE CORREIA; SAMPAIO, VANESSA FERNANDES ARNAUD; LA BANCA, SOPHIA; et al. Purinergic signaling in cognitive impairment and neuropsychiatric symptoms of Alzheimer's disease. Neuropharmacology, v. 226, p. 16-pg., 2023-01-12. (18/07366-4, 18/08426-0, 18/17504-5, 15/19128-2)

HIGA, GUILHERME SHIGUETO VILAR; FRANCIS-OLIVEIRA, JOSE; CARLOS-LIMA, ESTEVAO; TAMAIS, ALICIA MORAES; BORGES, FERNANDO DA SILVA; KIHARA, ALEXANDRE HIROAKI; SHIEH, IANE CARVALHO; ULRICH, HENNING; CHIAVEGATTO, SILVANA; DE PASQUALE, ROBERTO. 5-HT-dependent synaptic plasticity of the prefrontal cortex in postnatal development. SCIENTIFIC REPORTS, v. 12, n. 1, p. 23-pg., 2022-12-05. (19/21233-0, 17/06100-8, 16/09116-0, 22/00850-3, 16/25840-0, 17/20253-1, 18/07366-4, 19/14962-5)

MACHADO, RAFAEL R. G.; GLASER, TALITA; ARAUJO, DANIELLE B.; PETIZ, LYVIA LINTZMAIER; OLIVEIRA, DANIELLE B. L.; DURIGON, GIULIANA S.; LEAL, ALESSANDRA L.; PINHO, JOAO RENATO R.; FERREIRA, LUIS C. S.; ULRICH, HENNING; et al. Inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 Replication by Hypertonic Saline Solution in Lung and Kidney Epithelial Cells. ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE, v. 4, n. 5, p. 1514-1527, OCT 8 2021. (20/06409-1, 19/00195-2, 18/07366-4, 17/24769-2, 16/20045-7, 20/04680-0)

VILLEGAS, CECILIA; PEREZ, REBECA; PETIZ, LYVIA LINTZMAIER; GLASER, TALITA; ULRICH, HENNING; PAZ, CRISTIAN. Ginkgolides and Huperzine A for complementary treatment of Alzheimer's disease. IUBMB Life, v. 74, n. 8, p. 17-pg., 2022-04-05. (18/08426-0, 18/07366-4, 21/00060-0)

WANG, TAO; ULRICH, HENNING; SEMYANOV, ALEXEY; ILLES, PETER; TANG, YONG. Optical control of purinergic signaling. PURINERGIC SIGNALLING, v. 17, n. 3, p. 385-392, SEP 2021. (18/07366-4)

TROMBETTA-LIMA, MARINA; ASSIS-RIBAS, THAIS; CINTRA, RICARDO C.; CAMPEIRO, JOANA D.; GUERREIRO, JULIANO R.; WINNISCHOFER, SHEILA M. B.; NASCIMENTO, ISIS C. C.; ULRICH, HENNING; HAYASHI, MIRIAN A. F.; SOGAYAR, MARI C.. Impact of Reck expression and promoter activity in neuronal in vitro differentiation. MOLECULAR BIOLOGY REPORTS, v. 48, n. 2, FEB 2021. (18/20014-0, 16/05311-2, 18/07366-4, 14/50891-1, 19/13112-8, 15/26328-8, 16/18277-7, 12/50880-4, 17/02413-1)

SANTOS, ANDERSON K.; GOMES, KATIA N.; PARREIRA, RICARDO C.; SCALZO, SERGIO; PINTO, MAURO C. X.; SANTIAGO, HELTON C.; BIRBRAIR, ALEXANDER; SACK, ULRICH; ULRICH, HENNING; RESENDE, RODRIGO R.. Mouse Neural Stem Cell Differentiation and Human Adipose Mesenchymal Stem Cell Transdifferentiation Into Neuron-and Oligodendrocyte-like Cells With Myelination Potential. STEM CELL REVIEWS AND REPORTS, NOV 2021. (18/07366-4)

CARVALHO, GUSTAVO ALMEIDA; CAVALCANTE, DANIEL PEREIRA; PARREIRA, RICARDO CAMBRAIA; CHIARELI, RAPHAELA ALMEIDA; LEONCINI, GIOVANNI ORTIZ; GOMEZ, RENATO SANTIAGO; ULRICH, HENNING; CAIXETA, LEONARDO FERREIRA; OLIVEIRA-LIMA, ONESIA CRISTINA; PINTO, MAURO CUNHA XAVIER. Neurobiology of L-proline: From molecules to behavior. Neuroscience, v. 568, p. 14-pg., 2025-01-19. (18/07366-4)

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PILLAT, MICHELI MAINARDI; KRUGER, ARNE; FERREIRA GUIMARAES, LARA MENDES; LAMEU, CLAUDIANA; DE SOUZA, EDMARCIA ELISA; WRENGER, CARSTEN; ULRICH, HENNING. Insights in Chloroquine Action: Perspectives and Implications in Malaria andCOVID-19. Cytometry Part A, v. 97, n. 9, AUG 2020. (18/07366-4, 18/08820-0, 15/26722-8, 15/19128-2)

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TOMCZYK, MARTA; GLASER, TALITA; SLOMINSKA, EWA M.; ULRICH, HENNING; SMOLENSKI, RYSZARD T.. Purine Nucleotides Metabolism and Signaling in Huntington's Disease: Search for a Target for Novel Therapies. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 22, n. 12, JUN 2021. (18/07366-4)

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ARNAUD-SAMPAIO, VANESSA FERNANDES; ALVES RABELO, IZADORA LORRANY; ULRICH, HENNING; LAMEU, CLAUDIANA. The P2X7 Receptor in the Maintenance of Cancer Stem Cells, Chemoresistance and Metastasis. STEM CELL REVIEWS AND REPORTS, v. 16, n. 2, p. 288-300, APR 2020. (15/19128-2, 18/07366-4, 17/06132-7)

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FERREIRA, ANA FLAVIA F.; ULRICH, HENNING; FENG, ZHONG-PING; SUN, HONG-SHUO; BRITTO, LUIZ ROBERTO. Neurodegeneration and glial morphological changes are both prevented by TRPM2 inhibition during the progression of a Parkinson's disease mouse model. Experimental Neurology, v. 377, p. 15-pg., 2024-04-25. (20/02109-3, 18/07366-4, 22/14820-9)

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DE SOUZA, ANACLETO SILVA; DE FREITAS AMORIM, VITOR MARTINS; GUARDIA, GABRIELA D. A.; DOS SANTOS, FILIPE F.; ULRICH, HENNING; GALANTE, PEDRO A. F.; DE SOUZA, ROBSON FRANCISCO; GUZZO, CRISTIANE RODRIGUES. Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern: A Perspective for Emerging More Transmissible and Vaccine-Resistant Strains. Viruses-Basel, v. 14, n. 4, p. 21-pg., 2022-04-01. (18/07366-4, 20/06091-1, 19/00195-2, 16/09047-8, 20/14158-9, 20/04680-0, 17/18246-7, 17/19541-2, 18/15579-8)

KRUGER, ARNE; DE JESUS SANTOS, ANA PAULA; DE SA, VANESSA; ULRICH, HENNING; WRENGER, CARSTEN. Aptamer Applications in Emerging Viral Diseases. PHARMACEUTICALS, v. 14, n. 7, JUL 2021. (18/07366-4, 15/26722-8, 17/03966-4, 15/26642-4)

BIANCHETTI, MARIA E.; FERREIRA, ANA FLAVIA F.; BRITTO, LUIZ R. G.. Inhibition of neuroinflammation by GIBH-130 (AD-16) reduces neurodegeneration, motor deficits, and proinflammatory cytokines in a hemiparkinsonian model. FRONTIERS IN NEUROANATOMY, v. 18, p. 12-pg., 2024-12-16. (18/07366-4, 22/14846-8, 22/14820-9, 23/05618-4, 20/02109-3)

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SINGULANI, MONIQUE PATRICIO; FERREIRA, ANA FLAVIA FERNANDES; FIGUEROA, PAULINA SEPULVEDA; CUYUL-VASQUEZ, IVAN; TALIB, LEDA LEME; BRITTO, LUIZ ROBERTO; FORLENZA, ORESTES VICENTE. Lithium and disease modification: A systematic review and meta-analysis in Alzheimer's and Parkinson's disease. AGEING RESEARCH REVIEWS, v. 95, p. 20-pg., 2024-02-24. (20/02109-3, 18/07366-4, 21/06378-1, 14/50873-3)

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