Advanced search
Start date
Betweenand

Purine and kinin receptors as targets of study and therapeutic interventions in neurological diseases

Grant number: 18/07366-4
Support type:Research Projects - Thematic Grants
Duration: April 01, 2019 - March 31, 2024
Field of knowledge:Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
Principal researcher:Alexander Henning Ulrich
Grantee:Alexander Henning Ulrich
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Pesquisadores principais:
( Atuais )
Luiz Roberto Giorgetti de Britto
Pesquisadores principais:
( Anteriores )
Marimélia Aparecida Porcionatto
Assoc. researchers:Beatriz de Oliveira Monteiro ; Claudiana Lameu ; João Bosco Pesquero ; Luiz Henrique Catalani ; Marimélia Aparecida Porcionatto ; Mayana Zatz ; Roberto de Pasquale ; Roberto Kopke Salinas ; Silvana Chiavegatto
Associated scholarship(s):21/00060-0 - Role of P2Y14 receptor modulation in the hippocampal neuroinflammatory responses in in vitro and in vivo models of Alzheimer's Disease, BP.PD
21/05279-0 - The role of purinergic receptors and Huntingtin in gastrulation, BP.TT
21/04174-0 - Study of the bipolar disorder and Alzheimer's disease comorbidity using 3D cultures of decellularized brain extracellular matrix, BP.TT
+ associated scholarships 20/10725-6 - Evaluation of purinergic receptors in the comorbidity of bipolar disorder and Alzheimers Disease, BP.DD
20/07609-4 - Study of the neuroregeneration process triggered by bradykinin in the animal model of Parkinson's Disease, BP.IC
19/24553-5 - The role of P2Y1 receptor in Parkinsons Disease, BP.DR
19/26852-0 - Study of purinergic receptors antagonism in the inflammatory process and microglial cells activation using in vitro and in vivo models of Parkinsons Disease, BP.PD
18/17504-5 - Behavioral and molecular effects of pharmacological modulation of the P2Y2 receptors in an animal model of Alzheimer's Disease, BP.PD
19/03494-0 - Silencing of B1R and B2R kinin receptors in the BV-2 microglial cell line as a model of neuroinflammation response, BP.IC
15/15826-7 - Collagen hydrogel modified by bi-functional recombinant protein for transplantation of neural stem cells for the treatment of neurodegenerative disorder, BP.PD
15/19478-3 - Role of kinin-B2 receptor in pathogenesis and progression of familial Alzheimer's Disease: from neurogenesis and immune response to cognition, BP.PD
15/13345-1 - Huntington's disease: Huntingtin roles during cell fate decision, BP.PD - associated scholarships

Abstract

The biological process of neurogenesis that consists of differentiation of neural stem cells (NSC) into neurons, occurs both in embryonic and adult phases. Therefore, NSC are being proposed as interesting tools for nervous system tissue regeneration and restoration of physiological conditions, as well as models for elucidation of pathophysiological development of neurological diseases. Previous studies of our laboratory showed several signalling pathways involved in NSC development, especially through purinergic and kininergic receptors, whose modulation is essential in neural phenotype determination. Besides participating in adult brain neurotransmition in health conditions, their modulation reverted pathologic scenarios in animal and in vitro models of Parkinson's and Alzheimer's Disease. Taking into account these findings of our group, we proposed here a more profound investigation regarding mechanisms underlying in these effects, elucidating how purinergic and kininergic systems are involved and potential therapeutic targets for neurologic pathologies, especially associated with neurodegeneration/ regeneration and inflammatory process. Thus, the neurogenic, neuroprotective and immunomodulatory effects of purinergic and kininergic signalling will be studied in Parkinson's, Alzheimer's and Huntington's diseases and in bipolar disorder. Moreover, new tools based on nanotechnology, as biopolymers conjugated to bradikinin, will be used in NSC transplantation improvement as therapeutic alternative in animal models. (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
Déficit inicial 
Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (15)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PILLAT, MICHELI MAINARDI; OLIVEIRA-GIACOMELLI, AGATHA; DAS NEVES OLIVEIRA, MONA; ANDREJEW, ROBERTA; TURRINI, NATALIA; BARANOVA, JULIANA; LAH TURNSEK, TAMARA; ULRICH, HENNING. Mesenchymal stem cell-glioblastoma interactions mediated via kinin receptors unveiled by cytometry. Cytometry Part A, JAN 2021. Web of Science Citations: 0.
RIBEIRO, DEIDIANE ELISA; OLIVEIRA-GIACOMELLI, AGATHA; GLASER, TALITA; ARNAUD-SAMPAIO, VANESSA F.; ANDREJEW, ROBERTA; DIECKMANN, LUIZ; BARANOVA, JULIANA; LAMEU, CLAUDIANA; RATAJCZAK, MARIUSZ Z.; ULRICH, HENNING. Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology. MOLECULAR PSYCHIATRY, DEC 2020. Web of Science Citations: 0.
TRUJILLO, CLEBER A.; ADAMS, JASON W.; NEGRAES, PRISCILLA D.; CARROMEU, CASSIANO; TEJWANI, LEON; ACAB, ALLAN; TSUDA, BEN; THOMAS, CHARLES A.; SODHI, NEHA; FICHTER, KATHERINE M.; ROMERO, SARAH; ZANELLA, FABIAN; SEJNOWSKI, TERRENCE J.; ULRICH, HENNING; MUOTRI, ALYSSON R. Pharmacological reversal of synaptic and network pathology in human MECP2-KO neurons and cortical organoids. EMBO MOLECULAR MEDICINE, v. 13, n. 1 DEC 2020. Web of Science Citations: 0.
GLASER, TALITA; ANDREJEW, ROBERTA; OLIVEIRA-GIACOMELLI, AGATHA; RIBEIRO, DEIDIANE ELISA; MARQUES, LUCAS BONFIM; YE, QING; REN, WEN-JING; SEMYANOV, ALEXEY; ILLES, PETER; TANG, YONG; ULRICH, HENNING. Purinergic Receptors in Basal Ganglia Diseases: Shared Molecular Mechanisms between Huntington's and Parkinson's Disease. NEUROSCIENCE BULLETIN, v. 36, n. 11, SI, p. 1299-1314, NOV 2020. Web of Science Citations: 1.
PILLAT, MICHELI MAINARDI; KRUGER, ARNE; FERREIRA GUIMARAES, LARA MENDES; LAMEU, CLAUDIANA; DE SOUZA, EDMARCIA ELISA; WRENGER, CARSTEN; ULRICH, HENNING. Insights in Chloroquine Action: Perspectives and Implications in Malaria andCOVID-19. Cytometry Part A, v. 97, n. 9 AUG 2020. Web of Science Citations: 0.
ANDREJEW, ROBERTA; OLIVEIRA-GIACOMELLI, AGATHA; RIBEIRO, DEIDIANE ELISA; GLASER, TALITA; ARNAUD-SAMPAIO, VANESSA FERNANDES; LAMEU, CLAUDIANA; ULRICH, HENNING. The P2X7 Receptor: Central Hub of Brain Diseases. FRONTIERS IN MOLECULAR NEUROSCIENCE, v. 13, JUL 31 2020. Web of Science Citations: 0.
ARNAUD-SAMPAIO, VANESSA F.; RABELO, IZADORA L. A.; BENTO, CAROLINA A.; GLASER, TALITA; BEZERRA, JEAN; COUTINHO-SILVA, ROBSON; ULRICH, HENNING; LAMEU, CLAUDIANA. Using Cytometry for Investigation of Purinergic Signaling in Tumor-Associated Macrophages. Cytometry Part A, v. 97, n. 11 JUL 2020. Web of Science Citations: 1.
BOTTARI, NATHIELI B.; REICHERT, KARINE PAULA; FRACASSO, MATEUS; DUTRA, ANIELEN; ASSMANN, CHARLES ELIAS; ULRICH, HENNING; CHITOLINA SCHETINGER, MARIA ROSA; MORSCH, VERA M.; DA SILVA, ALEKSANDRO SCHAFER. Neuroprotective role of resveratrol mediated by purinergic signalling in cerebral cortex of mice infected byToxoplasma gondii. Parasitology Research, v. 119, n. 9 JUL 2020. Web of Science Citations: 0.
REICHERT, KARINE P.; PILLAT, MICHELI M.; SCHETINGER, MARIA ROSA C.; BOTTARI, NATHIELI B.; PALMA, V, TAIS; ASSMANN, CHARLES E.; GUTIERRES, JESSIE M.; ULRICH, HENNING; ANDRADE, CINTHIA M.; EXLEY, CHRISTOPHER; MORSCH, VERA M. M. Aluminum-induced alterations of purinergic signalling in embryonic neural progenitor cells. Chemosphere, v. 251, JUL 2020. Web of Science Citations: 0.
PALMA, TAIS VIDAL; LENZ, LUANA SUELING; BOTTARI, NATHIELE BIANCHIN; PEREIRA, ALINE; SCHETINGER, MARIA ROSA CHITOLINA; MORSCH, VERA MARIA; ULRICH, HENNING; PILLAT, MICHELI MAINARDI; DE ANDRADE, CINTHIA MELAZZO. Berberine induces apoptosis in glioblastoma multiforme U87MG cells via oxidative stress and independent of AMPK activity. MOLECULAR BIOLOGY REPORTS, v. 47, n. 6 MAY 2020. Web of Science Citations: 0.
RATAJCZAK, MARIUSZ Z.; ADAMIAK, MATEUSZ; BUJKO, KAMILA; THAPA, ARJUN; PENSATO, VALENTINA; KUCIA, MAGDA; RATAJCZAK, JANINA; ULRICH, HENNING. Innate immunity orchestrates the mobilization and homing of hematopoietic stem/progenitor cells by engaging purinergic signaling-an update. PURINERGIC SIGNALLING, MAY 2020. Web of Science Citations: 0.
ARNAUD-SAMPAIO, VANESSA FERNANDES; ALVES RABELO, IZADORA LORRANY; ULRICH, HENNING; LAMEU, CLAUDIANA. The P2X7 Receptor in the Maintenance of Cancer Stem Cells, Chemoresistance and Metastasis. STEM CELL REVIEWS AND REPORTS, v. 16, n. 2, p. 288-300, APR 2020. Web of Science Citations: 0.
GLASER, TALITA; SHIMOJO, HIROMI; RIBEIRO, DEIDIANE ELISA; MARTINS, PATRICIA PEREIRA LOPES; BECO, RENATA PEREIRA; KOSINSKI, MICHAL; SAMPAIO, VANESSA FERNANDES ARNAUD; CORREA-VELLOSO, JULIANA; OLIVEIRA-GIACOMELLI, AGATHA; LAMEU, CLAUDIANA; DE JESUS SANTOS, ANA PAULA; DE SOUZA, HELLIO DANNY NOBREGA; TENG, YANG D.; KAGEYAMA, RYOICHIRO; ULRICH, HENNING. ATP and spontaneous calcium oscillations control neural stem cell fate determination in Huntington's disease: a novel approach for cell clock research. MOLECULAR PSYCHIATRY, APR 2020. Web of Science Citations: 0.
VIVIANI, LUCAS G.; PICCIRILLO, ERIKA; ULRICH, HENNING; AMARAL, ANTONIA T-DO. Virtual Screening Approach for the Identification of Hydroxamic Acids as Novel Human Ecto-5 `-Nucleotidase Inhibitors. JOURNAL OF CHEMICAL INFORMATION AND MODELING, v. 60, n. 2, p. 621-630, FEB 2020. Web of Science Citations: 1.
OLIVEIRA-GIACOMELLI, AGATHA; ALBINO, CAROLINA M.; NOBREGA DE SOUZA, HELLIO DANNY; CORREA-VELLOSO, JULIANA; DE JESUS SANTOS, ANA PAULA; BARANOVA, JULIANA; ULRICH, HENNING. P2Y6 and P2X7 Receptor Antagonism Exerts Neuroprotective/ Neuroregenerative Effects in an Animal Model of Parkinson's Disease. FRONTIERS IN CELLULAR NEUROSCIENCE, v. 13, NOV 8 2019. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.