Characterization, study of cytokines and virus infections in stomatitis lesions related to the use of mTOR inhibitors in renal transplant patients.

• Grant number: 18/02568-8
• Support type: Regular Research Grants
• Duration: April 01, 2019 - March 31, 2022
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal researcher: Fabiana Martins e Martins de Oliveira
• Grantee: Fabiana Martins e Martins de Oliveira
• Home Institution: Universidade de Santo Amaro (UNISA). São Paulo , SP, Brazil
• Assoc. researchers: Aluisio Augusto Cotrim Segurado ; Elias David-Neto ; Ligia Camera Pierrotti ; Paulo Henrique Braz da Silva

Abstract

The mammalian target of mTOR, a serine / threonine kinase is associated with several cellular activities. Due to the several cellular activities that are attributed to this protein, drugs have been developed inhibiting its function, the mTOR inhibitors (imTOR), represented by sirolimus, and everolimus. ImTOR are associated with severe adverse events (AE), patients on everolimus therapy most commonly exhibit the following AE: hyperlipidemia, dermatitis, oral stomatitis. The mTOR-induced stomatitis (mIAS) has as differential diagnosis recurrent aphthous stomatitis or herpesvirus lesions The aim of this study is to analyze the cytokine profile and to investigate the presence of human herpesviruses during the post-renal transplant period in renal transplant patients who developed or not stomatitis associated with the use of imTOR and to comparatively evaluate patients who use other immunosuppressants; evaluate the incidence of oral lesions in individuals using of imTOR and to analyze possible cytological changes in smears from renal transplant patients, correlating to oral alterations and the drugs used. Saliva, peripheral blood and oral epithelial cells smears will be collected in renal transplant recipients using mTOR inhibitors and other types of immunosuppressive therapies (G1mTOR and G2imuno). The following cytokines will be analyzed: (IL-6, IFN-gama, IL-10, \ IL-8, e TNF-alfa); PCR for the detection and quantification of herpesvirus (whole blood,saliva) polyomaviruses (BK) (whole blood) will be used for viruses screening. The cytological alterations will be studied using the Papanicolau technique. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE OLIVEIRA, MARCIO AUGUSTO; REIS, BRUNA; PALLOS, DEBORA; KIM, YEON JUNG; BRAZ-SILVA, PAULO HENRIQUE; MARTINS, FABIANA. The Importance of Histopathological Examination to the Final Diagnosis of Peripheral Odontogenic Tumors: A Case Report of a Peripheral Odontoma. CASE REPORTS IN DENTISTRY, v. 2019, SEP 8 2019. Web of Science Citations: 0.