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Nanostructured interfaces for the investigation of bioactive substances in cell membrane models and for the construction of optoelectronic devices

Abstract

In this project, we intend to use structures organized at the molecular level at interfaces as cell membrane models, and for the immobilization of enzymes for the production of enzymatic optoelectronic devices. For that, we will use Langmuir monolayers and Langmuir-Blodgett (LB) films. The films will be produced from materials of pharmacological and / or technological interest, in which insoluble amphiphiles, such as lipids, forming a monolayer at the air-water interface, pure or mixed with proteins, and bioactive potential compounds such as those with antifungal, or antitumor activity, will interact with the interface and be investigated by means of tensiometric, electrical, rheological, spectroscopic and morphological measurements. It is also intended to immobilize enzymes, antibodies and moieties of nucleic acids in LB films for the production of optoelectronic devices capable of molecular recognition. As a result, substances that aid in the molecular accommodation, modulating the biological activity and the response signal of the interaction, will be employed. Candidates include conductive polymers, metal nanoparticles, polysaccharides, graphene, and carbon nanotubes. In this sense, the remarkable interaction that the proponent has with groups inside and outside the institution, specialists in the obtaining of bioactive materials of interest, in Molecular Biology, and in the synthesis of conducting polymers. This fact allows, therefore, to make up such specialties, investigating at the molecular level interactions that aid in the understanding of biophysical and biochemical processes in cell membranes and also assist in the construction of intelligent surfaces constructed from bioinspired interfaces organized at the molecular level for the manufacture of optoelectronic devices such as biosensors. (AU)

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Scientific publications (20)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RODRIGUES, RAUL TORRES; SOUZA NORDI, CRISTIANA FREIRE; SIQUEIRA JUNIOR, JOSE ROBERTO; CASELI, LUCIANO. Effect of interfering agents for urease immobilized in Langmuir-Blodgett films of controlled molecular architecture. Thin Solid Films, v. 704, . (19/03239-0, 16/01867-6)
RODRIGUES, REBECA DA ROCHA; CASELI, LUCIANO; PERES, LAURA OLIVEIRA. Langmuir and Langmuir-Blodgett Films of Poly[(9,9-dioctylfluorene)-co-(3-hexylthiophene)] for Immobilization of Phytase: Possible Application as a Phytic Acid Sensor. Langmuir, v. 36, n. 35, p. 10587-10596, . (19/03239-0, 14/50869-6)
MACHADO, ANDRE CAMPOS; CASELI, LUCIANO. Ultrathin films to investigate the interaction of nitrofurantoin with phospholipids. Thin Solid Films, v. 725, . (18/25943-9, 19/03239-0, 18/22214-6)
SAKAI, ANDREI; DE SOUSA MESQUITA, ANA PAULA; DE CASTRO LEVATTI, ERICA VALADARES; STRAUS, ANITA HILDA; NADER, HELENA B.; LOPES, CARLA CRISTINA; CASELI, LUCIANO. Interaction of Trastuzumab with biomembrane models at air-water interfaces mimicking cancer cell surfaces. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1861, n. 10, . (19/03239-0, 15/23446-0, 13/14262-7)
PAROLIN, GIOVANA A.; GONCALVES, GIULIA E. G.; COSTA-SILVA, THAIS A.; TEMPONE, ANDRE G.; CASELI, LUCIANO; LAGO, JOAO HENRIQUE G.; PERES, LAURA O.. Evaluation of the effects in cellular membrane models of antitrypanosomal poly-thymolformaldehyde (PTF) using Langmuir monolayers. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1863, n. 2, . (18/22214-6, 14/50869-6, 18/07885-1, 18/18180-9, 18/10279-6, 19/03239-0)
JAROQUE, GUILHERME NUNEZ; SARTORELLI, PATRICIA; CASELI, LUCIANO. Peptidoglycans modulating the interaction of a bactericide compound with lipids at the air-water interface. Chemistry and Physics of Lipids, v. 237, . (19/03239-0, 18/22214-6)
RODRIGUES ROLA POSSARLE, LUIZ HENRIQUE; SIQUEIRA JUNIOR, JOSE ROBERTO; CASELI, LUCIANO. Insertion of carbon nanotubes in Langmuir-Blodgett films of stearic acid and asparaginase enhancing the catalytic performance. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 192, . (19/03239-0)
DE SOUZA FURTADO, FERNANDO AUGUSTO; CASELI, LUCIANO. Enzyme activity preservation for galactose oxidase immobilized in stearic acid Langmuir-Blodgett films. Thin Solid Films, v. 709, . (19/03239-0)
DA SILVA, RAFAEL LEONARDO C. G.; GONCALVES, KARINA DE OLIVEIRA; COURROL, LILIA CORONATO; CASELI, LUCIANO. Study of the interactions of gold nanoparticles functionalized with aminolevulinic acid in membrane models. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 205, . (19/03239-0, 18/00291-9, 17/23686-6, 18/22214-6)
RODRIGUES, RAUL T.; JR., JOSE R. SIQUEIRA; CASELI, LUCIANO. Structural and viscoelastic properties of floating monolayers of a pectinolytic enzyme and their influence on the catalytic properties. Journal of Colloid and Interface Science, v. 589, p. 568-577, . (14/50869-6, 18/22214-6, 18/22091-1, 19/03239-0)
CRUZ GOMES DA SILVA, RAFAEL LEONARDO; SHARMA, SHIV K.; PAUDYAL, SURAJ; MINTZ, KEENAN J.; LEBLANC, ROGER M.; CASELI, LUCIANO. Surface Chemistry Studies on the Formation of Mixed Stearic Acid/Phenylalanine Dehydrogenase Langmuir and Langmuir-Blodgett Films. Langmuir, v. 37, n. 25, p. 7771-7779, . (19/01797-6, 18/22214-6, 18/00291-9, 19/03239-0)
DE SOUZA FURTADO, FERNANDO AUGUSTO; BERRIO ESCOBAR, JHON FERNANDO; MARTINEZ, ALEJANDRO MARTINEZ; GIORDANI, CRISTIANO; ALMEIDA CAIUT, JOSE MAURICIO; CASELI, LUCIANO; MOLINA, CELSO. Molecular Information on the Potential of Europium Complexes for Local Recognition of a Nucleoside-Based Drug by Using Nanostructured Interfaces Assembled as Langmuir-Blodgett Films. Langmuir, v. 36, n. 14, p. 3843-3852, . (19/03239-0)
RODRIGUES, REBECA DA ROCHA; CRUZ GOMES DA SILVA, RAFAEL LEONARDO; CASELI, LUCIANO; PERES, LAURA OLIVEIRA. Conjugated polymers as Langmuir and Langmuir-Blodgett films: Challenges and applications in nanostructured devices. ADVANCES IN COLLOID AND INTERFACE SCIENCE, v. 285, . (18/00291-9, 14/50869-6, 19/03239-0)
BARBOSA, HENRIQUE; DA SILVA, RAFAEL LEONARDO C. G.; COSTA-SILVA, THAIS A.; TEMPONE, ANDRE G.; ANTAR, GUILHERME M.; LAGO, JOAO HENRIQUE G.; CASELI, LUCIANO. Interaction of dicentrinone, an antitrypanosomal aporphine alkaloid isolated from Ocotea puberula (Lauraceae), in cell membrane models at the air-water interface. BIOORGANIC CHEMISTRY, v. 101, . (18/00291-9, 18/10279-6, 19/03239-0, 18/07885-1)
JAROQUE, GUILHERME NUNEZ; SARTORELLI, PATRICIA; CASELI, LUCIANO. The effect of the monocyclic monoterpene tertiary alcohol gamma-terpineol on biointerfaces containing cholesterol. Chemistry and Physics of Lipids, v. 230, . (19/03239-0)
ROSA, MATHEUS ELIAS; ALVES CONSERVA, GEANNE A.; LAGO, JOAO HENRIQUE G.; CASELI, LUCIANO. nteraction of isolinderanolide E obtained from Nectandra oppositifolia with biomembrane model. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1863, n. 10, . (19/03239-0, 16/20633-6, 18/22214-6, 19/04407-4)
SAKAI, ANDREI; DE SOUSA MESQUISTA, ANA PAULA; NADER, HELENA B.; LOPES, CARLA CRISTINA; NAKANISHI, WAKA; ARIGA, KATSUHIKO; CASELI, LUCIANO. The lipid composition affects Trastuzumab adsorption at monolayers at the air-water interface. Chemistry and Physics of Lipids, v. 227, . (19/03239-0)

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