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Nanocarriers for localized treatment and chemoprevention of breast tumors

Grant number: 18/13877-1
Support type:Research Grants - Young Investigators Grants- Phase 2
Duration: May 01, 2019 - April 30, 2024
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal researcher:Luciana Biagini Lopes
Grantee:Luciana Biagini Lopes
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Ana Paula Lepique ; João Agostinho Machado Neto ; Leticia Veras Costa Lotufo ; Soraia Katia Pereira Costa
Associated research grant:13/16617-7 - Nanostructured systems for topical delivery and co-localization of chemopreventive and chemoterapeutic agents in the skin and breast tissue, AP.JP
Associated grant(s):19/21910-1 - Multi-User Equipment approved in grant 208/13877-1: equipment for high performance liquid chromatography (HPLC), AP.EMU
Associated scholarship(s):21/06755-0 - Evaluation of nanoemulsions for local-transdermal administration of fenretinide for breast cancer chemoprevention, BP.MS
19/26048-6 - Development and application of multifunctional nanocarriers for intraductal delivery of chemotherapy aiming at Breast Cancer treatment, BP.DR
20/04633-1 - Study of the influence of nanocarriers and drug combinations on cell viability and migration, BP.IC
+ associated scholarships 19/03241-5 - Preparation and evaluation of oral nanocarriers of 5-fluorouracil and intestinal metabolics, BP.DR
20/01208-8 - Bioadhesive nanostructured systems for intraductal administration and localized treatment of Breast Cancer, BP.DD
18/14375-0 - Nanotechnology-based topical delivery systems for breast cancer chemoprevention, BP.PD - associated scholarships

Abstract

Considering the high incidence of breast tumors and the lack of strategies for local management of non-invasive cases, as well as effective, safe and well-accepted chemoprevention alternatives for high-risk population, we propose the development of nanotechnology-based strategies to fill this gap. To increase treatment efficacy, we propose to co-encapsulate combinations of cytotoxic, cicloxigenase-2 inhibitors and anti-proliferative agents, which may potentiate each other effects due to interference with multiple signaling pathways. We will develop nanocarriers for the intraductal, topical and subcutaneous routes, aiming local application to the breast tissue. Nanoemulsions, polyelectrolyte nanoparticles, nanodispersions and microemulsions will be developed, and their diameter, zeta potential, rheological, bioadhesive and swelling properties will be characterized. Subsequently, we will study the influence of composition on skin permeability, skin penetration and percutaneous delivery, irritation potential, formulation residence and drug delivery in the mammary tissue. The influence of nanoencapsulation and association of drugs on cytotoxicity and anti-proliferative effects, as well as selective effects of drugs and formulations against cancer cells will be assessed in 2D cultures and 3D multicellular spheroids. Results from these studies will enable selection of formulations for assessment of in vivo efficacy in models of breast cancer. (AU)

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Scientific publications (15)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BARRETO, THAYNA L.; LOPES, LUCIANA B.; MELO, ANALY S. A.; ISHIDA, KELLY. In vivo synergism of free miltefosine or in alginate-based nanocarrier combined with voriconazole on aspergillosis. FUTURE MICROBIOLOGY, v. 16, n. 15 OCT 2021. Web of Science Citations: 0.
SALATA, GIOVANNA CASSONE; MALAGO, ISABELLA D.; CARVALHO DARTORA, VANESSA F. M.; MARCAL PESSOA, ANA FLAVIA; DE ABREU FANTINI, MARCIA CARVALHO; COSTA, SORAIA K. P.; MACHADO-NETO, JOAO AGOSTINHO; LOPES, LUCIANA B. Microemulsion for Prolonged Release of Fenretinide in the Mammary Tissue and Prevention of Breast Cancer Development. MOLECULAR PHARMACEUTICS, v. 18, n. 9, p. 3401-3417, SEP 6 2021. Web of Science Citations: 0.
APOLINARIO, ALEXSANDRA CONCEICAO; HAUSCHKE, LEON; NUNES, JESSICA RIBEIRO; LOURENCO, FELIPE REBELLO; LOPES, LUCIANA BIAGINI. Design of multifunctional ethosomes for topical fenretinide delivery and breast cancer chemoprevention. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 623, AUG 20 2021. Web of Science Citations: 0.
COSTA-FERNANDEZ, SANDRA; MATOS, JENYFFER K. R.; SCHEUNEMANN, GABY S.; SALATA, GIOVANNA C.; CHORILLI, MARLUS; WATANABE, IL-SEI; DE ARAUJO, GABRIEL L. B.; SANTOS, MARINILCE F.; ISHIDA, KELLY; LOPES, LUCIANA B. Nanostructured lipid carriers containing chitosan or sodium alginate for co-encapsulation of antioxidants and an antimicrobial agent for potential application in wound healing. International Journal of Biological Macromolecules, v. 183, p. 668-680, JUL 31 2021. Web of Science Citations: 1.
MOJEIKO, GABRIELA; PASSOS, JULIA SAPIENZA; APOLINARIO, ALEXSANDRA CONCEICAO; LOPES, LUCIANA BIAGINI. Topical transdermal chemoprevention of breast cancer: where will nanomedical approaches deliver us?. Nanomedicine, JUL 2021. Web of Science Citations: 0.
APOLINARIO, ALEXSANDRA CONCEICAO; HAUSCHKE, LEON; NUNES, JESSICA RIBEIRO; LOPES, LUCIANA BIAGINI. Lipid nanovesicles for biomedical applications: `What is in a name'?. PROGRESS IN LIPID RESEARCH, v. 82, APR 2021. Web of Science Citations: 3.
GIACONE, V, DANIELA; DARTORA, VANESSA F. M. C.; DE MATOS, JENYFFER K. R.; PASSOS, JULIA S.; MIRANDA, DANIEL A. G.; DE OLIVEIRA, ERICA A.; SILVEIRA, EDILBERTO R.; COSTA-LOTUFO, V, LETICIA; MARIA-ENGLER, SILVYA S.; LOPES, LUCIANA B. Effect of nanoemulsion modification with chitosan and sodium alginate on the topical delivery and efficacy of the cytotoxic agent piplartine in 2D and 3D skin cancer models. International Journal of Biological Macromolecules, v. 165, n. A, p. 1055-1065, DEC 15 2020. Web of Science Citations: 2.
APOLINARIO, ALEXSANDRA CONCEICAO; HAUSCHKE, LEON; NUNES, JESSICA RIBEIRO; LOPES, LUCIANA BIAGINI. Towards nanoformulations for skin delivery of poorly soluble API: What does indeed matter?. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 60, DEC 2020. Web of Science Citations: 0.
BARRETO, THAYNA LOPES; ROSSATO, LUANA; DUARTE DE FREITAS, ALINE LUIZA; MEIS, JACQUES F.; LOPES, LUCIANA BIAGINI; COLOMBO, ARNALDO LOPES; ISHIDA, KELLY. Miltefosine as an alternative strategy in the treatment of the emerging fungus Candida auris. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, v. 56, n. 2 AUG 2020. Web of Science Citations: 0.
SANTOS, ROGERIO A.; RAE, MARIANA; DARTORA, VANESSA F. M. C.; MATOS, JENYFFER K. R.; CAMARINI, ROSANA; LOPES, LUCIANA B. Bioresponsive nanostructured systems for sustained naltrexone release and treatment of alcohol use disorder: Development and biological evaluation. International Journal of Pharmaceutics, v. 585, JUL 30 2020. Web of Science Citations: 0.
PASSOS, JULIA SAPIENZA; DE MARTINO, LUIZA CAPELLO; CARVALHO DARTORA, VANESSA FRANCO; DE ARAUJO, GABRIEL L. B.; ISHIDA, KELLY; LOPES, LUCIANA B. Development, skin targeting and antifungal efficacy of topical lipid itraconazole. European Journal of Pharmaceutical Sciences, v. 149, JUN 15 2020. Web of Science Citations: 0.
SPADARI, CRISTINA DE CASTRO; WIRTH, FERNANDA; LOPES, LUCIANA BIAGINI; ISHIDA, KELLY. New Approaches for Cryptococcosis Treatment. MICROORGANISMS, v. 8, n. 4 APR 2020. Web of Science Citations: 7.
MENDES DA SILVA DE BASTIANI, FERNANDA WALT; SPADARI, CRISTINA DE CASTRO; ROCHA DE MATOS, JENYFFER KELLY; SALATA, GIOVANNA CASSONE; LOPES, LUCIANA BIAGINI; ISHIDA, KELLY. Nanocarriers Provide Sustained Antifungal Activity for Amphotericin B and Miltefosine in the Topical Treatment of Murine Vaginal Candidiasis. FRONTIERS IN MICROBIOLOGY, v. 10, JAN 10 2020. Web of Science Citations: 0.
ALEXSANDRA CONCEIÇÃO APOLINÁRIO; GIOVANNA CASSONE SALATA; ARTHUR F. R. BIANCO; CLAUDIO FUKUMORI; LUCIANA BIAGINI LOPES. ABRINDO A CAIXA DE PANDORA DOS NANOMEDICAMENTOS: HÁ REALMENTE MUITO MAIS ‘ESPAÇO LÁ EMBAIXO’. Química Nova, v. 43, n. 2, p. 212-225, Fev. 2020.
CARVALHO, VANESSA F. M.; SALATA, GIOVANNA C.; DE MATOS, JENYFFER K. R.; COSTA-FERNANDEZ, SANDRA; CHORILLI, MARLUS; STEINER, ALEXANDRE A.; DE ARAUJO, GABRIEL L. B.; SILVEIRA, EDILBERTO R.; COSTA-LOTUFO, V, LETICIA; LOPES, LUCIANA B. Optimization of composition and obtainment parameters of biocompatible nanoemulsions intended for intraductal administration of piplartine (piperlongumine) and mammary tissue targeting. International Journal of Pharmaceutics, v. 567, AUG 15 2019. Web of Science Citations: 2.

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