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Integrative biology applied to human health

Grant number: 18/14933-2
Support type:Research Grants - Young Investigators Grants - Phase 2
Duration: May 01, 2019 - April 30, 2024
Field of knowledge:Interdisciplinary Subjects
Principal researcher:Helder Takashi Imoto Nakaya
Grantee:Helder Takashi Imoto Nakaya
Home Institution: Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE). Sociedade Beneficente Israelita Brasileira Albert Einstein (SBIBAE). São Paulo , SP, Brazil
Assoc. researchers:Esper Georges Kallás ; Fernando Augusto Bozza ; Frederico Moraes Ferreira ; Luciano da Fontoura Costa ; Luis Carlos de Souza Ferreira ; Mario Hiroyuki Hirata ; Paola Marcella Camargo Minoprio ; Patricia Cristina Baleeiro Beltrão Braga ; Ricardo Tostes Gazzinelli ; Sergio Schenkman ; Vanderson de Souza Sampaio
Associated research grant:12/19278-6 - Systems biology of long non-coding RNAs, AP.JP
Associated grant(s):19/16444-1 - Systems immunology approach for resolving the mechanisms of vaccine-induced classical swine fever protection, AP.R SPRINT
Associated scholarship(s):20/05284-0 - Interaction of microorganisms and human hosts associated with the clinical outcome of patients with infectious diseases, BP.DD
20/12017-9 - Machine learning for interpretation and analysis of microscopic images, BP.PD
19/27139-5 - Application of genomic tools for the study of epidemiological databases, BP.DD
19/27146-1 - Integration of transcriptome data with clinical and immunological data, BP.DD
19/16419-7 - Study of transmission of diseases using cell phone from infected people, BP.DD

Abstract

Data related to human health, from clinical and epidemiological information to medical images and omics data, are being generated and accumulated in an unprecedented amount in history. The analysis and integration of such information is critical to improve our understanding of the pathophysiology of diseases, their transmission, as well as their diagnosis and treatment. This project proposes innovative approaches for: analyzing large epidemiological databases; mapping hotspots of disease transmission; integrating transcriptome data with clinical and immunological data; and using machine learning for interpretation and analysis of microscopic images. State-of-the-art techniques or systems analyses and machine learning will be used and even developed for each approach, taking into account the foundations of integrative biology. We hope that the results of the project can clarify several problems related to human health, from the automatic analysis of microscopic slides to the molecular mechanisms of infectious and inflammatory diseases (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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VEICULO: TITULO (DATA)

Scientific publications (12)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GONCALVES, ANDRE N. A.; LEVER, MELISSA; RUSSO, PEDRO S. T.; GOMES-CORREIA, BRUNO; URBANSKI, ALYSSON H.; POLLARA, GABRIELE; NOURSADEGHI, MAHDAD; MARACAJA-COUTINHO, VINICIUS; NAKAYA, I, HELDER. Assessing the Impact of Sample Heterogeneity on Transcriptome Analysis of Human Diseases Using MDP Webtool. FRONTIERS IN GENETICS, v. 10, . (13/08216-2, 12/19278-6, 18/14933-2)
AGUIAR, RENATO S.; POHL, FABIO; MORAIS, GUILHERME L.; NOGUEIRA, FABIO C. S.; DE CARVALHO, JOSEANE B.; GUIDA, LETICIA; ARGE, LUIS W. P.; MELO, ADRIANA; MOREIRA, MARIA E. L.; CUNHA, DANIELA P.; et al. Molecular alterations in the extracellular matrix in the brains of newborns with congenital Zika syndrome. Science Signaling, v. 13, n. 635, . (13/08216-2, 12/19278-6, 18/21934-5, 17/50137-3, 18/14933-2)
SANTOS E SILVA, JUAN CARLO; VASCONCELOS, AMANDA PEREIRA; YONEHARA NOMA, ISABELLA HARUMI; NORONHA, NATALIA YUMI; AQUINO, RODRIGO; GIDDALURU, JEEVAN; DURAO, LUIZ; COSTA-MARTINS, ANDRE GUILHERME; SCHUCH, VIVIANE; MORAES-VIEIRA, PEDRO M.; et al. Gene signatures of autopsy lungs from obese patients with COVID-19. CLINICAL NUTRITION ESPEN, v. 44, p. 475-478, . (19/27139-5, 18/14933-2, 20/04579-7, 19/27146-1)
PERON, J. P. S.; NAKAYA, I, H.; SCHLINDWEIN, M. A. M.; GONCALVES, M. V. M.. COVID-19 Pandemic and Dysbiosis: Can the Ivermectin Hysteria Lead to an Increase of Autoimmune Neuroinflammatory Diseases?. CRITICAL REVIEWS IN IMMUNOLOGY, v. 40, n. 6, SI, p. 537-542, . (17/22504-1, 18/14933-2, 12/19278-6, 13/08216-2, 18/21934-5, 19/06372-3, 17/21363-5)
CREIGHTON, RACHEL; SCHUCH, VIVIANE; URBANSKI, ALYSSON H.; GIDDALURU, JEEVAN; COSTA-MARTINS, ANDRE G.; NAKAYA, I, HELDER. Network vaccinology. SEMINARS IN IMMUNOLOGY, v. 50, . (18/14933-2, 17/27131-9, 13/08216-2, 18/21934-5)
JIMENEZ, LEANDRO; CODO, ANA CAMPOS; SAMPAIO, VANDERSON DE SOUZA; OLIVEIRA, ANTONIO E. R.; KOBO FERREIRA, LUCAS KAORU; DAVANZO, GUSTAVO GASTAO; MONTEIRO, LAUAR DE BRITO; VIRGILIO-DA-SILVA, JOAO VICTOR; SILVA BORBA, MAYLA GABRIELA; DE SOUZA, GABRIELA FABIANO; et al. Acid pH Increases SARS-CoV-2 Infection and the Risk of Death by COVID-19. FRONTIERS IN MEDICINE, v. 8, . (18/14933-2, 20/04836-0)
CANDIDO, DARLAN S.; CLARO, INGRA M.; DE JESUS, JAQUELINE G.; SOUZA, WILLIAM M.; MOREIRA, FILIPE R. R.; DELLICOUR, SIMON; MELLAN, THOMAS A.; DU PLESSIS, LOUIS; PEREIRA, RAFAEL H. M.; SALES, FLAVIA C. S.; et al. Evolution and epidemic spread of SARS-CoV-2 in Brazil. Science, v. 369, n. 6508, SI, p. 1255+, . (19/24251-9, 16/18445-7, 18/14933-2, 18/14389-0, 18/09383-3, 19/21301-5, 17/13981-0, 20/04836-0, 19/07544-2, 20/04558-0, 16/00194-8, 18/25468-9, 18/17176-8, 19/12000-1)
GONZALEZ-DIAS, PATRICIA; LEE, EVA K.; SORGI, SARA; DE LIMA, DIOGENES S.; URBANSKI, ALYSSON H.; SILVEIRA, EDUARDO LV; NAKAYA, HELDER I.. Methods for predicting vaccine immunogenicity and reactogenicity. HUMAN VACCINES & IMMUNOTHERAPEUTICS, v. 16, n. 2, . (13/08216-2, 18/21934-5, 18/14933-2)
ARIAS-CARRASCO, RAUL; GIDDALURU, JEEVAN; CARDOZO, LUCAS E.; MARTINS, FELIPE; MARACAJA-COUTINHO, VINICIUS; NAKAYA, HELDER I.. OUTBREAK: a user-friendly georeferencing online tool for disease surveillance. Biological Research, v. 54, n. 1, . (18/14933-2, 13/08216-2, 19/16419-7, 18/21934-5, 17/50137-3)
BRANDAO, W. N.; DE OLIVEIRA, M. G.; ANDREONI, R. T.; NAKAYA, H.; FARIAS, A. S.; PERON, J. P. S.. Neuroinflammation at single cell level: What is new?. Journal of Leukocyte Biology, . (13/08216-2, 18/21934-5, 17/50137-3, 17/26170-0, 12/19278-6, 17/22504-1, 17/21363-5, 18/14933-2, 19/06372-3)
PINTO, BRUNA G. G.; OLIVEIRA, ANTONIO E. R.; SINGH, YOUVIKA; JIMENEZ, LEANDRO; GONCALVES, ANDRE N. A.; OGAVA, RODRIGO L. T.; CREIGHTON, RACHEL; SCHATZMANN PERON, JEAN PIERRE; NAKAYA, I, HELDER. ACE2 Expression Is Increased in the Lungs of Patients With Comorbidities Associated With Severe COVID-19. Journal of Infectious Diseases, v. 222, n. 4, p. 556-563, . (12/19278-6, 17/50137-3, 18/21934-5, 18/14933-2, 13/08216-2)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.