Musculoskeletal aging: metabolic and functional repercussions and mortality risk in people aged 50 and older

• Grant number: 18/13917-3
• Support Opportunities: Research Grants - Young Investigators Grants
• Duration: June 01, 2019 - May 31, 2024
• Field of knowledge: Health Sciences - Physiotherapy and Occupational Therapy
• Principal Investigator: Tiago da Silva Alexandre
• Grantee: Tiago da Silva Alexandre
• Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Associated researchers: Cesar Messias de Oliveira
• Associated scholarship(s): 22/09886-0 - Structuring and Organization of Databases, BP.TT; 21/11505-2 - Sarcopenia and dynapenia as risk factors for mobility decline in the elderly: an analysis with different cutoff points, BP.MS; 21/11142-7 - Do the reduction of forced vital capacity (FVC), of forced expiratory volume in the first second (FEV1) and the ratio FEV1/FVC reduce muscle strength in the elderly?, BP.MS; + associated scholarships 21/06169-3 - Structuring and Organization of Databases, BP.TT; 20/06716-1 - Incidence of low serum levels of Vitamin D in individuals with and without abdominal obesity, BP.IC; 20/02040-3 - Uncontrolled systemic arterial hypertension and diabetes accelerate the decline in memory and executive function in people over 50 years old?, BP.MS; 19/14699-2 - Structuring and organization of databases, BP.TT - associated scholarships

Abstract

There is a gap in the understanding of the relationship between abdominal obesity, low vitamin D serum levels and dynapenia later in life. However, there is strong evidence suggesting that these three conditions may be interconnected and part of the same mechanism that affects negatively musculoskeletal health and, consequently, metabolic and functional capacity later in life. Therefore, the objectives of the present proposal are: i) to analyze the incidence of dynapenia in individuals with and without vitamin D deficiency; ii) to analyze the incidence of low vitamin D serum levels in subjects with and without abdominal obesity; iii) to analyze the association between dynapenic abdominal obesity and the trajectory of metabolic disorders of carbohydrates, lipids, systemic arterial pressure, mobility disability and lower limbs functional limitation; iv) to analyze the association between dynapenic abdominal obesity and the incidence of metabolic syndrome and cardiovascular mortality. Data from the English Longitudinal Study of Ageing (ELSA), a long-term multi-cohort study that began in 2002 and has more than 15 years of follow-up, will be used. This project benefits from an existing research partnership between the candidate and the University College London (UCL). In order to answer each of the questions in this proposal, we will use incidence density analyzes, Poisson and logistic regression models, Kaplan-Meyer curves, Cox regression models and Generalized Linear Mixed Models. Our hypotheses are: i) the incidence of dynapenia is higher in individuals with low serum vitamin D levels; (ii) the incidence of low serum vitamin D levels is higher in obese individuals; and (iii) trajectories of lower limb function, mobility disability and changes in carbohydrate, lipid and blood pressure metabolism as well as the incidence of metabolic syndrome and mortality due to cardiovascular diseases are higher in obese individuals. (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NEBULONI, CLARICE CAVALERO; MAXIMO, ROBERTA DE OLIVEIRA; DE OLIVEIRA, CESAR; ALEXANDRE, TIAGO DA SILVA. Uncontrolled Diabetes as an Associated Factor with Dynapenia in Adults Aged 50 Years or Older: Sex Differences. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, v. 75, n. 6, p. 1191-1197, JUN 2020. (18/13917-3)

COCHAR-SOARES, NATALIA; DE CARVALHO, DANILO H. T.; DE ANDRADE, FABIOLA B.; CASTRO-COSTA, ERICO; DE OLIVEIRA, CESAR; LIMA-COSTA, MARIA F.; ALEXANDRE, TIAGO DA S.. Does undiagnosed diabetes mitigate the association between diabetes and cognitive impairment? Findings from theELSI-Brazilstudy. JOURNAL OF DIABETES, JUL 2020. (17/22818-6, 18/13917-3)

MAXIMO, ROBERTA DE OLIVEIRA; DE OLIVEIRA, DAYANE CAPRA; CAMILA RAMIREZ, PAULA; LUIZ, MARIANE MARQUES; DE SOUZA, ALINE FERNANDA; BICIGO DELINOCENTE, MAICON LUIS; STEPTOE, ANDREW; DE OLIVEIRA, CESAR; ALEXANDRE, TIAGO DA SILVA. ynapenia, abdominal obesity or both: which accelerates the gait speed decline most. AGE AND AGEING, v. 50, n. 5, p. 1616-1625, SEP 2021. (18/13917-3, 17/26377-4)

ROBERTA DE OLIVEIRA MÁXIMO; INGRID CRISTINA LOPES; ALLAN GUSTAVO BRIGOLA; BRUNA MORETTI LUCHESI; ALINE CRISTINA MARTINS GRATÃO; KEIKA INOUYE; SOFIA CRISTINA IOST PAVARINI; TIAGO DA SILVA ALEXANDRE. Pre-frailty, frailty and associated factors in older caregivers of older adults. Revista de Saúde Pública, v. 54, 2020-01-31. (17/26377-4, 18/13917-3)

LUIZ, MARIANE M.; MAXIMO, ROBERTA; OLIVEIRA, DAYANE C.; RAMIREZ, PAULA C.; DE SOUZA, ALINE F.; DELINOCENTE, MAICON L. B.; STEPTOE, ANDREW; DE OLIVEIRA, CESAR; ALEXANDRE, TIAGO. Association of Serum 25-Hydroxyvitamin D Deficiency with Risk of Incidence of Disability in Basic Activities of Daily Living in Adults > 50 Years of Age. Journal of Nutrition, v. 150, n. 11, p. 2977-2984, NOV 2020. (18/13917-3)

BICIGO DELINOCENTE, MAICON LUIS; TREVISAN DE CARVALHO, DANILO HENRIQUE; MAXIMO, ROBERTA DE OLIVEIRA; NISIHARA CHAGAS, MARCOS HORTES; FERREIRA SANTOS, JAIR LICIO; DE OLIVEIRA DUARTE, YEDA APARECIDA; STEPTOE, ANDREW; DE OLIVEIRA, CESAR; ALEXANDRE, TIAGO DA SILVA. Accuracy of different handgrip values to identify mobility limitation in older adults. ARCHIVES OF GERONTOLOGY AND GERIATRICS, v. 94, MAY-JUN 2021. (18/13917-3, 09/53778-3)

DE OLIVEIRA, DAYANE CAPRA; MAXIMO, ROBERTA DE OLIVEIRA; RAMIREZ, PAULA CAMILA; DE SOUZA, ALINE FERNANDA; LUIZ, MARIANE MARQUES; BICIGO DELINOCENTE, MAICON LUIS; NISIHARA CHAGAS, MARCOS HORTES; STEPTOE, ANDREW; DE OLIVEIRA, CESAR; ALEXANDRE, TIAGO DA SILVA. Is slowness a better discriminator of disability than frailty in older adults?. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, SEP 2021. (18/13917-3)