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Photophysical characterization and anti-inflammatory potential of betalains

Grant number: 19/06391-8
Support type:Regular Research Grants
Duration: July 01, 2019 - June 30, 2021
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal researcher:Erick Leite Bastos
Grantee:Erick Leite Bastos
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated grant(s):19/08450-1 - Natural photoredox and photobioredox mediators, AP.R SPRINT


Betalains are chromoalkaloids found in plants and fungi that have been used as drugs, redox mediators, antioxidants and safe dyes. In this research project, we propose to: i) optimize the biotechnological production of betalamic acid, the biosynthetic precursor of betalains, ii) produce betalains anti-inflammatories that act at the level of NF-ºB and COX-1/COX-2, iii) develop betalamic rotaxanes that self-assemble in aqueous media, iv) include data on natural betalains in the PhotochemCAD database by invitation of its development group, and v) understand the behavior of electronically excited betalains by employing ultra-fast spectroscopy. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVA, SANDRA M.; LANG, ANDRE P.; DOS SANTOS, ANA PAULA F.; CABELLO, MAIDILEYVIS C.; CISCATO, LUIZ FRANCISCO M. L.; BARTOLONI, FERNANDO H.; BASTOS, ERICK L.; BAADER, WILHELM J. Cyclic Peroxidic Carbon Dioxide Dimer Fuels Peroxyoxalate Chemiluminescence. Journal of Organic Chemistry, v. 86, n. 17, p. 11434-11441, SEP 3 2021. Web of Science Citations: 0.
PINHEIRO, AMANDA CAPISTRANO; FAZZI, RODRIGO BONI; ESTEVES, LARISSA CERRATO; MACHADO, CAROLINE OLIVEIRA; DORR, FELIPE AUGUSTO; PINTO, ERNANI; HATTORI, YOCEFU; SA, JACINTO; FERREIRA, ANA MARIA DA COSTA; BASTOS, ERICK LEITE. A bioinspired nitrone precursor to a stabilized nitroxide radical. Free Radical Biology and Medicine, v. 168, p. 110-116, MAY 20 2021. Web of Science Citations: 0.
FREITAS-DORR, B. C.; MACHADO, C. O.; PINHEIRO, A. C.; FERNANDES, A. B.; DORR, F. A.; PINTO, E.; LOPES-FERREIRA, M.; ABDELLAH, M.; SA, J.; RUSSO, L. C.; FORTI, F. L.; GONCALVES, L. C. P.; BASTOS, L. L. A metal-free blue chromophore derived from plant pigments. SCIENCE ADVANCES, v. 6, n. 14 APR 2020. Web of Science Citations: 0.
FERNANDES, ARTHUR B.; PAVLIUK, V, MARIIA; PAUN, CRISTINA; CARVALHO, ALEXANDRINA C.; NOMURA, CASSIANA S.; LEWIN, ERIK; LINDBLAD, REBECKA; CAMARGO, PEDRO H. C.; SA, JACINTO; BASTOS, ERICK L. Recoverable and Reusable Polymer Microbead-Supported Metal Nanocatalysts for Redox Chemical Transformations. ACS APPLIED NANO MATERIALS, v. 3, n. 2, p. 1722-1730, FEB 2020. Web of Science Citations: 0.
PENNA, TATIANA C.; CERVI, GUSTAVO; RODRIGUES-OLIVEIRA, ANDRE F.; YAMADA, BRUNO D.; LIMA, RAFAEL Z. C.; MENEGON, JAIR J.; BASTOS, ERICK L.; CORRERA, THIAGO C. Development of a photoinduced fragmentation ion trap for infrared multiple photon dissociation spectroscopy. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, FEB 2020. Web of Science Citations: 0.
NAKASHIMA, KARINA K.; BASTOS, ERICK L. Rationale on the High Radical Scavenging Capacity of Betalains. ANTIOXIDANTS, v. 8, n. 7 JUL 2019. Web of Science Citations: 0.

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