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Photophysical characterization and anti-inflammatory potential of betalains

Grant number: 19/06391-8
Support Opportunities:Regular Research Grants
Duration: July 01, 2019 - June 30, 2021
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Erick Leite Bastos
Grantee:Erick Leite Bastos
Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated grant(s):19/08450-1 - Natural photoredox and photobioredox mediators, AP.R SPRINT


Betalains are chromoalkaloids found in plants and fungi that have been used as drugs, redox mediators, antioxidants and safe dyes. In this research project, we propose to: i) optimize the biotechnological production of betalamic acid, the biosynthetic precursor of betalains, ii) produce betalains anti-inflammatories that act at the level of NF-ºB and COX-1/COX-2, iii) develop betalamic rotaxanes that self-assemble in aqueous media, iv) include data on natural betalains in the PhotochemCAD database by invitation of its development group, and v) understand the behavior of electronically excited betalains by employing ultra-fast spectroscopy. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERNANDES, ARTHUR B.; PAVLIUK, V, MARIIA; PAUN, CRISTINA; CARVALHO, ALEXANDRINA C.; NOMURA, CASSIANA S.; LEWIN, ERIK; LINDBLAD, REBECKA; CAMARGO, PEDRO H. C.; SA, JACINTO; BASTOS, ERICK L.. Recoverable and Reusable Polymer Microbead-Supported Metal Nanocatalysts for Redox Chemical Transformations. ACS APPLIED NANO MATERIALS, v. 3, n. 2, p. 1722-1730, . (14/22136-4, 17/10346-2, 19/08450-1, 19/06391-8, 15/25629-4)
NAKASHIMA, KARINA K.; BASTOS, ERICK L.. Rationale on the High Radical Scavenging Capacity of Betalains. ANTIOXIDANTS, v. 8, n. 7, . (13/24964-9, 14/22136-4, 16/21445-9, 19/06391-8)
PENNA, TATIANA C.; CERVI, GUSTAVO; RODRIGUES-OLIVEIRA, ANDRE F.; YAMADA, BRUNO D.; LIMA, RAFAEL Z. C.; MENEGON, JAIR J.; BASTOS, ERICK L.; CORRERA, THIAGO C.. Development of a photoinduced fragmentation ion trap for infrared multiple photon dissociation spectroscopy. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, . (14/15962-5, 15/08539-1, 16/19698-6, 19/06391-8, 17/20262-0, 18/20592-3)
PINHEIRO, AMANDA CAPISTRANO; FAZZI, RODRIGO BONI; ESTEVES, LARISSA CERRATO; MACHADO, CAROLINE OLIVEIRA; DORR, FELIPE AUGUSTO; PINTO, ERNANI; HATTORI, YOCEFU; SA, JACINTO; FERREIRA, ANA MARIA DA COSTA; BASTOS, ERICK LEITE. A bioinspired nitrone precursor to a stabilized nitroxide radical. Free Radical Biology and Medicine, v. 168, p. 110-116, . (19/06391-8, 15/18474-4, 19/15412-9, 13/07937-8, 14/22136-4)
DA SILVA, SANDRA M.; LANG, ANDRE P.; DOS SANTOS, ANA PAULA F.; CABELLO, MAIDILEYVIS C.; CISCATO, LUIZ FRANCISCO M. L.; BARTOLONI, FERNANDO H.; BASTOS, ERICK L.; BAADER, WILHELM J.. Cyclic Peroxidic Carbon Dioxide Dimer Fuels Peroxyoxalate Chemiluminescence. Journal of Organic Chemistry, v. 86, n. 17, p. 11434-11441, . (19/06391-8, 14/22136-4)
FREITAS-DORR, B. C.; MACHADO, C. O.; PINHEIRO, A. C.; FERNANDES, A. B.; DORR, F. A.; PINTO, E.; LOPES-FERREIRA, M.; ABDELLAH, M.; SA, J.; RUSSO, L. C.; et al. A metal-free blue chromophore derived from plant pigments. SCIENCE ADVANCES, v. 6, n. 14, . (18/25842-8, 14/10563-5, 16/21445-9, 15/25629-4, 14/22136-4, 19/06391-8, 15/24760-0, 15/18474-4)

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