Advanced search
Start date
Betweenand
Related content

Toxoplasma gondii GENETIC DIVERSITY IN THE SOUTHERN REGION OF BRAZIL AND STUDY OF ITS POPULATION STRUCTURE IN THE COUNTRY

Grant number: 18/26071-5
Support Opportunities:Regular Research Grants
Start date: June 01, 2019
End date: November 30, 2021
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Preventive Veterinary Medicine
Principal Investigator:Hilda Fátima de Jesus Pena
Grantee:Hilda Fátima de Jesus Pena
Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated researchers:Arlei Marcili ; Daniel Ajzenberg ; Herbert Sousa Soares ; Ricardo Augusto Dias ; Solange de Oliveira ; Solange Maria Gennari

Abstract

Toxoplasmosis is a zoonosis of worldwide distribution. Brazil has one of the highest seroprevalence rates of Toxoplasma gondii in the world. Free-living chickens have been used for seroprevalence studies of T. gondii and genotypic characterization of isolates in order to understand the parasite population structure and its biological characteristics in different regions of the world. The isolates of T. gondii from South America are highly diverse and this diversity may be related to the occurrence of severe ocular and congenital toxoplasmosis. In Brazil, some lineages are widely distributed and are considered clonal and are called BrI, BrII and BrIII types, with low occurrence of classical clones I, II and III and predominance of "atypical" strains, but there are no recent studies on the structure of the parasite in Brazil, considering a representative panel of samples from all Brazilian regions. Archetypes I, II and III have been described only in the Southern Region. The objectives of the project are to determine the frequency of anti-T. gondii antibodies from hens raised in the rural areas of the municipalities with the lowest human development index (HDI) of the South Region, isolating T. gondii in the region, genotyping the isolates obtained (using PCR-RFLP, microsatellite analysis (MS) and introns sequencing), and, finally, the review of the parasite population structure in the country using MS. It is expected to understand the population structure of T. gondii in the Southern Region of Brazil, particularly regarding the impact of the circulation of the three classic clonal types I, II and III. It is also expected to understand the current structure of the agent, considering the five regions of the national territory, comparing the results found in the South Region with available data of genotyping of samples from other regions of Brazil, by MS, regarding the diversity of isolates and groups, existence of geographic subpopulations and occurrence of gene flow between two populations. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
More itemsLess items
Articles published in other media outlets ( ):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MEIRELES, LUCIANA REGINA; MACHADO BEZERRA, ELIZAMA CARNEIRO; ANDRADE, JOELMA QUEIROZ; CASSIANO, LARISSA APARECIDA; JESUS PENA, HILDA FATIMA; ALVES, BRUNA FARIAS; VIEIRA FRANCISCO, ROSSANA PULCINELI; DE ANDRADE JR, HEITOR FRANCO. Isolation and characterization of Toxoplasma gondii isolates from human congenital toxoplasmosis cases reveal a new virulent genotype in Sao Paulo, Brazil. Parasitology Research, v. 121, n. 11, p. 6-pg., . (18/26071-5)
REIS AMENDOEIRA, MARIA REGINA; ARRUDA, IGOR FALCO; MOREIRA, SILVIA BAHADIAN; UBIALI, DANIEL GUIMARAES; BARBOSA, ALYNNE DA SILVA; JESUS PENA, HILDA FATIMA; BARBOSA PEREIRA, ASHELEY HENRIQUE; NASCIMENTO DA SILVEIRA, CLARISSA; BONIFACIO, THAMIRES FRANCISCO; CLEMES, YARA SOUZA; et al. Isolation and genetic characterization of Toxoplasma gondii from a captive black-and-gold howler monkey (Alouatta caraya Humboldt, 1812) in Brazil. INTERNATIONAL JOURNAL FOR PARASITOLOGY-PARASITES AND WILDLIFE, v. 19, p. 4-pg., . (18/26071-5)
RICO-TORRES, CLAUDIA PATRICIA; VALENZUELA-MORENO, LUIS FERNANDO; LUNA-PASTEN, HECTOR; CEDILLO-PELAEZ, CARLOS; CORREA, DOLORES; MORALES-SALINAS, ELIZABETH; MARTINEZ-MAYA, JOSE JUAN; ALVES, BRUNA FARIAS; PENA, HILDA FATIMA JESUS; CABALLERO-ORTEGA, HERIBERTO. Genotyping of toxoplasma gondii isolates from Mexico reveals non-archetypal and potentially virulent strains for mice. INFECTION GENETICS AND EVOLUTION, v. 113, p. 8-pg., . (18/26071-5)