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Biomolecular markers of proliferation and remodeling in acute and chronic respiratory diseases: promise therapeutic targets

Grant number: 18/20403-6
Support type:Research Projects - Thematic Grants
Duration: June 01, 2019 - May 31, 2024
Field of knowledge:Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
Principal Investigator:Vera Luiza Capelozzi
Grantee:Vera Luiza Capelozzi
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Edwin Roger Parra-Cuentas ; Lisete Ribeiro Teixeira ; Patricia Rieken Macedo Rocco ; Pedro Leme Silva
Associated scholarship(s):20/01758-8 - Study of cellular, subcellular (especially mitochondria) and matrix components of bronchioles, alveoli and diaphragms by electron microscopy in pre-clinical models of gene and drug therapy and ventilatory strategies in Asthma and COPD, BP.TT
19/12151-0 - Evaluation of the protein expression of DLL-3 and ASCL-1 as a new perspective in biomarkers for the early diagnosis of small cell lung carcinomas, BP.PD

Abstract

The prevalence and social cost of respiratory diseases such as lung cancer, acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease, asthma, silicosis, and pulmonary arterial hypertension are high and some of them have few therapeutic alternatives. The therapy of most of these diseases is based on symptomatic control and not on effective cure. The present proposal has as main objective the understanding of the activation and regulation pathways of the cellular responses to insults and also the development of the underlying mechanisms in the repair and remodeling of the lesions. There is a consensus that the elucidation of the pathways and factors involved in these responses will increase the ability to identify and develop more effective treatments for disease control as proposed in this project. The project will have the participation of researchers linked to 7 different institutions: (1) University of São Paulo: Pathology Department of FMUSP-SP, (2) University of São Paulo: Rheumatology Department of FMUSP-SP, São Paulo: Department of Pathology of FMUSP-RP, (4) Federal University of Rio de Janeiro: Carlos Chagas Filho Institute of Biophysics, (5) Universidade Estadual Paulista: Department of Genetics of IBB / UNESP, (6) Hospital AC Camargo Cancer Center and (7) Hospital de Cancer de Barretos. It is worth emphasizing the active participation of emerging researchers included in the group that maintains a work association and co-authorship of different degrees and extensions, as a result of post-doctoral or postdoctoral orientation histories. Post-doctoral students, graduate students and scientific initiation, as well as laboratory technicians, will participate in different subprojects generated from this proposal already in progress. This project will also count on the collaboration of professors and researchers outside Brazil: Dr. Ignacio Wistuba and Dr. Edwin Roger Parra - The University of Texas, M.D. Anderson Cancer Center, Department of Translational Molecular Pathology, USA. Postdoctoral student (Brazil) - The University of Texas, M.D. Anderson Cancer Center, Department of Translational Molecular Pathology, USA; Prof. Dr. Sem H. Phan, University of Michigan, Ann Arbor-MI, USA. The researchers associated with this proposal propose, with the knowledge and experience - in several cases jointly acquired - to advance in the investigation of biomarkers that may contribute to the development of new therapeutic strategies in respiratory diseases. (AU)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARTINS, VANESSA; DA SILVA, ADRIANA LOPES; TEODORO, WALCY ROSOLIA; PEREIRA VELOSA, ANA PAULA; BALANCIN, MARCELO LUIZ; CRUZ, FERNANDA FERREIRA; SILVA, PEDRO LEME; MACEDO ROCCO, PATRICIA RIEKEN; CAPELOZZI, VERA LUIZA. In situ evidence of collagen V and signaling pathway of found inflammatory zone 1 (FIZZ1) is associated with silicotic granuloma in lung mice. PATHOLOGY RESEARCH AND PRACTICE, v. 216, n. 9 SEP 2020. Web of Science Citations: 0.
BALANCIN, MARCELO LUIZ; TEODORO, WALCY ROSOLIA; FARHAT, CECILIA; DE MIRANDA, TOMAS JURANDIR; ASSATO, ALINE KAWASSAKI; DE SOUZA SILVA, NEILA APARECIDA; VELOSA, ANA PAULA; FALZONI, ROBERTO; AB'SABER, ALEXANDRE MUXFELDT; RODEN, ANJA C.; CAPELOZZI, VERA LUIZA. An integrative histopathologic clustering model based on immuno-matrix elements to predict the risk of death in malignant mesothelioma. CANCER MEDICINE, v. 9, n. 13 MAY 2020. Web of Science Citations: 0.
FELIX, RENATO GONCALVES; CARVALHO BOVOLATO, ANA LIVIA; COTRIM, ONDINA SILVIA; LEAO, PATRICIA DOS SANTOS; BATAH, SABRINA SETEMBRE; GOLIM, MARJORIE DE ASSIS; VELOSA, ANA PAULA; TEODORO, WALCY; MARTINS, VANESSA; CRUZ, FERNANDA FERREIRA; DEFFUNE, ELENICE; FABRO, ALEXANDRE TODOROVIC; CAPELOZZI, VERA LUIZA. Adipose-derived stem cells and adipose-derived stem cell-conditioned medium modulate in situ imbalance between collagen I-and collagen V-mediated IL-17 immune response recovering bleomycin pulmonary fibrosis. HISTOLOGY AND HISTOPATHOLOGY, v. 35, n. 3, p. 289-301, MAR 2020. Web of Science Citations: 0.
TEODORO, WALCY ROSOLIA; DE JESUS QUEIROZ, ZELITA APARECIDA; DOS SANTOS, LAIS ARAUJO; CATANOZI, SERGIO; DOS SANTOS FILHO, ANTONIO; BUENO, CLEONICE; VENDRAMINI, MARGARETE B. G.; FERNEZLIAN, SANDRA DE MORAIS; EHER, ESMERALDA M.; SAMPAIO-BARROS, PERCIVAL D.; PASOTO, SANDRA GOFINET; LOPES, FERNANDA DEGOBBI T. Q. S.; PEREIRA VELOSA, ANA PAULA; CAPELOZZI, VERA LUIZA. Proposition of a novel animal model of systemic sclerosis induced by type V collagen in C57BL/6 mice that reproduces fibrosis, vasculopathy and autoimmunity. ARTHRITIS RESEARCH & THERAPY, v. 21, n. 1 DEC 1 2019. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.