EVALUATION OF POLOXAMER-HYALURONIC ACID BASED SUFORAPHANE GEL FORMULATIONS IN A POST OPERATIVE PAIN MODEL

• Grant number: 19/06969-0
• Support Opportunities: Regular Research Grants
• Duration: August 01, 2019 - January 31, 2022
• Field of knowledge: Biological Sciences - Pharmacology - General Pharmacology
• Principal Investigator: Giovana Tofoli Moniz
• Grantee: Giovana Tofoli Moniz
• Host Institution: Centro de Pesquisas Odontológicas São Leopoldo Mandic. Faculdade São Leopoldo Mandic (SLMANDIC). Sociedade Regional de Ensino e Saúde S/S Ltda (SRES). Campinas , SP, Brazil

Abstract

Postoperative pain is not adequately managed in greater than 80% of patients that underwent surgical procedures and only one at four patients received adequate prescription for this condition. Poorly controlled acute postoperative pain is associated with increased morbidity, functional and quality-of-life impairment, delayed recovery time, prolonged duration of opioid use, higher health-care costs. In addition, the presence and intensity of acute pain during or after surgery is predictive of the development of chronic pain. Conventional therapies (opioids, NSAIDs, local anesthetics) remain the standard for the management of acute postoperative pain; however, these drugs present limitations such as short duration of action, need for multiple dosage usage, low tolerance and dose related adverse effects. One promising strategy would be the use of sulforaphane (SFN) that presents antinociceptive and anti-inflammatory properties. Considering that postoperative pain control is still a challenge and more effective analgesic/anesthetic measures in the perioperative period are needed, SFN in drug delivery systems could be a new strategy for postoperative pain. Looking for applications of such novel formulations for postoperative pain control, we aimed to evaluate new SFN formulations with thermoreversible gels for postoperative pain control in animal models. (AU)